{"created":"2023-07-25T08:12:25.122557+00:00","id":12761,"links":{},"metadata":{"_buckets":{"deposit":"7d4a22b3-eb82-4005-b360-c49a10b7705b"},"_deposit":{"created_by":3,"id":"12761","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"12761"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00012761","sets":["228:230:5136","57:86"]},"author_link":["124212"],"control_number":"12761","item_5_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1996","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"49","bibliographicPageStart":"41","bibliographicVolumeNumber":"48","bibliographic_titles":[{"bibliographic_title":"鹿児島大学医学雑誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Medical journal of Kagoshima University","bibliographic_titleLang":"en"}]}]},"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"1996-12-02","subitem_date_issued_type":"Issued"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"1996-12-02"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Effects of methylmercuric chloride (MMC) on the brain acetylcholine (ACh) levels and operant behavior were investigated in rats and mice. Acquisition of T-maze or shuttle box aviodance behaviors was significantly suppresscd in mice，after daily administration of MMC (6mg/kg/day p.o.) for scvcn days. ACh levels in the hippocampus was decreased in mice even 3 hours after single oral dose of MMC (6mg/kg). After 3 days of the treatment with MMC (6mg/kg p.o.，6 successive days)，ACh levels in all regions tested (cerebral cortex， cerebellum，hippocampus，corpus striatum， diencephalonmesencephalon and pons medulla)were significantly decreased in mice. In vitro study， ACh release from hippocampal slice of MMC treated (6mg/kg p.o.) mice was significantly enhanced by high potassium stimulation. In rats，daily oral administration of MMC (5mg/kg) for 10 successive days produced significant decrease of ACh levels in 5 regions without pons medulla， and suppressed the retrieval in conditioned avoidance behavior (Sidman type). In vivo microdialysis study，ACh release from rats corpus striatum was significantly enhanced by MMC (10^{-4}M) contained perfusate. From these results， it is concluded that oral administration of MMC decreascd brain ACh levels and suppressed\nconditioned avoidance behavior in rats and mice.","subitem_description_language":"en","subitem_description_type":"Other"},{"subitem_description":"医歯学総合研究科博士論文(医学) ; 学位取得日: 平成8年12月2日","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.11501/3120576","subitem_identifier_reg_type":"JaLC"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"},{"subitem_publisher":"Kagoshima University","subitem_publisher_language":"en"}]},"item_5_relation_32":{"attribute_name":"関連（relation）","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://id.ndl.go.jp/bib/000000305767","subitem_relation_type_select":"URI"}}]},"item_5_relation_33":{"attribute_name":"関連（isVersionOf）","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dl.ndl.go.jp/info:ndljp/pid/3120576","subitem_relation_type_select":"URI"}}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0368-5063","subitem_source_identifier_type":"PISSN"}]},"item_5_source_id_9":{"attribute_name":"NII書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN00040104","subitem_source_identifier_type":"NCID"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"499","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"平成22年度に行われた国立国会図書館の学位論文（博士）デジタル化事業に際し、著者から、学位授与大学において、国立国会図書館から譲渡を受けた学位論文のデジタル化複製物を利用（全文複写提供、公衆送信）に供することの許諾を受けたものです（参考：http://www.ndl.go.jp/jp/aboutus/digitization_theses.html）。"}]},"item_5_text_52":{"attribute_name":"学位番号","attribute_value_mlt":[{"subitem_text_value":"医論第1117号"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"村尾, 光治","creatorNameLang":"ja"},{"creatorName":"ムラオ, コウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Murao, Koji","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-31"}],"displaytype":"detail","filename":"000000305767.pdf","filesize":[{"value":"7.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"000000305767.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/12761/files/000000305767.pdf"},"version_id":"fe4c9040-b872-42b9-8f3c-827997881ec5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"methylmercury","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"acetylcholine (ACh)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"operant behavior","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"methylmercury intoxication","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"脳内アセチルコリンおよび条件行動に及ぼすメチル水銀の影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"脳内アセチルコリンおよび条件行動に及ぼすメチル水銀の影響","subitem_title_language":"ja"},{"subitem_title":"Effects of Methylmercury on the Brain Acetylcholine Levels and the Conditioned Avoidance Behavior in Rats and Mice","subitem_title_language":"en"},{"subitem_title":"ノウナイ アセチルコリン オヨビ ジョウケン コウドウ ニ オヨボス メチル スイギン ノ エイキョウ","subitem_title_language":"ja-Kana"}]},"item_type_id":"5","owner":"3","path":["5136","86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2015-04-28"},"publish_date":"2015-04-28","publish_status":"0","recid":"12761","relation_version_is_last":true,"title":["脳内アセチルコリンおよび条件行動に及ぼすメチル水銀の影響"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-01-09T05:43:00.705891+00:00"}