{"created":"2023-07-25T08:12:31.645807+00:00","id":12904,"links":{},"metadata":{"_buckets":{"deposit":"3c16a5f2-125c-4f6b-a78c-5668e8282c4b"},"_deposit":{"created_by":18,"id":"12904","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"12904"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00012904","sets":["57:80"]},"author_link":["6517"],"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-04-27","subitem_date_issued_type":"Collected"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2011-2011年度科学研究費助成事業(学術研究助成基金助成金(挑戦的萌芽研究))研究成果報告書　課題番号：23659491　研究代表者：丸山征郎 (鹿児島大学大学院医歯学総合研究科特任教授)","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"我々はこれまで、壊死細胞核由来のHMGB1が受容体；RAGE, TLR-2,-4を介して炎症性サイトカインとして働くこと、細胞外HMGB1はトロンボモジュリン（TM）のN末端に活性を失い、さらにトロンビンによって分解されdes-HMGB1が生成されること、このdes-HMGB1は受容体レベルでHMGB1と競合して、非炎症性に働くことを明らかにしてきた。そこで今回は、des-HMGB1の特異的ELISAと、これを用いたHMGB1のダイナミズムについて研究した。結果、des-HMGB1はDICやショックの患者の血清中に増加していた。特に遺伝子組換えTM治療でその傾向が強かった。現在、このdes-HMGB1値と治療効果、重症度、予後などとの関連を研究中である。","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"We previously showed that HMGB1 binds to thrombomodulin(TM) and degraded by thrombin-TM at the N-terminus of the molecule cleaving out 10 aminoacdid-residue. We named this degraded HMGB1 as des-HMGB1.We also have showed that des-HMGB1 compete with intact binding to its receptor RAGE, Toll-like receptor-2 and -4 resulting negatively regulating of intact HMGB1 and its receptor signaling.\nIn this study, we established the des-HMGB1 specific assay ELISA, and investigated its dynamism in various diseases including DIC, sepsis and shock. We showed that the des-HMGB1 was increased in the serum from the patients with these pathologic conditions, especially in the cases treated with recombinant TM. We are now further studying relationship between des-HMGB1 levels and the efficacy of TM treatment and their prognosis.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"Kagoshima University","subitem_publisher_language":"en"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"493","subitem_subject_scheme":"NDC"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"23659491"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"丸山, 征郎","creatorNameLang":"ja"},{"creatorName":"MARUYAMA, Ikuro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"6517","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000020082282","nameIdentifierScheme":"NRID","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-31"}],"displaytype":"detail","filename":"23659491seika.pdf","filesize":[{"value":"201.0 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"23659491seika.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/12904/files/23659491seika.pdf"},"version_id":"c6b4693a-22f6-426c-9f73-acc5d8d42928"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"血栓","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"止血学","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"T-TMにより分子修飾されたHMGB1の測定法の確立と生体内ダイナミズムの解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"T-TMにより分子修飾されたHMGB1の測定法の確立と生体内ダイナミズムの解析","subitem_title_language":"ja"},{"subitem_title":"Establishment and dynamism of des-HMGB1, degraded HMGB1 by thrombin-thrombomodulin","subitem_title_language":"en"}]},"item_type_id":"8","owner":"18","path":["80"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-12-24"},"publish_date":"2014-12-24","publish_status":"0","recid":"12904","relation_version_is_last":true,"title":["T-TMにより分子修飾されたHMGB1の測定法の確立と生体内ダイナミズムの解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-05-24T00:24:41.384334+00:00"}