@article{oai:ir.kagoshima-u.ac.jp:00013110,
 author = {Kaneko, Koichi and 金子, 公一 and Ishigami, Sumiya and 石神, 純也 and Kijima, Yuko and 喜島, 祐子 and Funasako, Yawara and 舩迫, 和 and Hirata, Munetsugu and 平田, 宗嗣 and Okumura, Hiroshi and 奥村, 浩 and Shinchi, Hiroyuki and 新地, 洋之 and Koriyama, Chihaya and 郡山, 千早 and Ueno, Shinichi and 上野, 真一 and Yoshinaka, Heiji and 吉中, 平次 and Natsugoe, Shoji and 夏越, 祥次},
 journal = {BMC Cancer},
 month = {},
 note = {Background: Human leukocyte antigen (HLA)-class I molecules on tumor cells have been regarded as crucial sites where cytotoxic T lymphocytes (CTL) can recognize tumor-specific antigens and are strongly associated with antitumor activity. However, the clinical impact of HLA class I expression in breast cancer has not been clarified.
Methods: A total of 212 breast cancer patients who received curative surgery from 1993 to 2003 were enrolled in the current study. HLA class I expression was examined immunohistochemically using an anti-HLA class I monoclonal antibody. The correlation between HLA class I positivity and clinical factors was analyzed.
Results: The downregulation of HLA class I expression in breast cancer was observed in 69 patients (32.5%). HLA class I downregulation was significantly associated with nodal involvement (p < 0.05), TNM stage (p < 0.05), lymphatic invasion (p < 0.01), and venous invasion (p < 0.05). Patients with preserved HLA class I had significantly better disease-free interval (DFI) than those with loss of HLA class I (p < 0.05). However, in multivariable analysis, HLA class I was not selected as one of the independent prognostic factors of disease-free interval.
Conclusion: The examination of HLA class I expression is useful for the prediction of tumor progression and recurrent risk of breast cancer via the antitumor immune system.},
 title = {Clinical implication of HLA class I expression in breast cancer},
 volume = {11},
 year = {2011},
 yomi = {カネコ, コウイチ and イシガミ, スミヤ and キジマ, ユウコ and フナサコ, ヤワラ and ヒラタ, ムネツグ and オクムラ, ヒロシ and シンチ, ヒロユキ and コオリヤマ, チハヤ and ウエノ, シンイチ and ヨシナカ, ヘイジ and ナツゴエ, ショウジ}
}