{"created":"2023-07-25T08:12:48.933983+00:00","id":13250,"links":{},"metadata":{"_buckets":{"deposit":"41b20b3e-473e-407c-b5b8-08e0e6845f07"},"_deposit":{"created_by":3,"id":"13250","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"13250"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00013250","sets":[]},"author_link":["50505","118139","118140"],"item_8_alternative_title_18":{"attribute_name":"別言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Development of new tumor markers based on microRNA expression in urine of the patients with urothelial carcinoma"}]},"item_8_alternative_title_19":{"attribute_name":"タイトルよみ","attribute_value_mlt":[{"subitem_alternative_title":"ニョウロ ジョウヒ ガン カンジャ ニョウチュウ ニ ソンザイスル マイクロ RNA オ キテン トシタ シンキ シンダンホウ ノ カイハツ ケンキュウ"}]},"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-06-18"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2011-2013年度科学研究費助成事業（基盤研究（C））研究成果報告書　課題番号：23501298　研究代表者：榎田英樹（鹿児島大学・医歯（薬）学総合研究科・准教授）","subitem_description_type":"Other"},{"subitem_description":"我々は膀胱癌におけるmicroRNAの発現プロファイルを同定して新たな膀胱癌の診断マーカーの開発を行った。膀胱癌患者100例、健常者49例、尿路感染症患者25例でのレトロスペクティブな検討ではmiR-96とmiR-183は良好な感度・特異度を持って癌と非癌の区別が可能であった。これらの発現はステージ、グレードと相関し、筋層非浸潤癌の再発を予防することが可能であった。さらに前向き試験として血尿を主訴として外来を受診した患者（尿路上皮癌56例、尿路結石35例、尿路感染症51例）においてはmiR-Xは血尿による疑陽性率が少なく有望な腫瘍マーカーと考えられた。","subitem_description_type":"Other"},{"subitem_description":"We developed novel urine markers for detecting urothelial carcinoma. Retrospective examination using 100 bladder cancer, 49 healthy volunteers, and 25 urinary tract infection patients revealed that miR-96 and miR-183 could distinguish cancer from benign disease with good sensitivity and specificity. These miRNAs expressions were well correlated with tumor stage and grade as recurrence free survival of non-muscle invasive blader cancer. As for prospective examination of the out patients with macroscopic hematuria revealed that miR-X was a promising tumor markers with less false posive affected by macroscopic hematuria.","subitem_description_type":"Other"}]},"item_8_full_name_2":{"attribute_name":"著者よみ","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"エノキダ, ヒデキ"}]}]},"item_8_full_name_3":{"attribute_name":"別言語の著者","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"ENOKIDA, Hideki"}]}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"494","subitem_subject_scheme":"NDC"}]},"item_8_text_24":{"attribute_name":"公開者よみ","attribute_value_mlt":[{"subitem_text_value":"カゴシマ ダイガク"}]},"item_8_text_25":{"attribute_name":"公開者別名","attribute_value_mlt":[{"subitem_text_value":"Kagoshima University"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"23501298"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"榎田, 英樹"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-31"}],"displaytype":"detail","filename":"23501298_榎田英樹.pdf","filesize":[{"value":"183.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"23501298_榎田英樹.pdf","url":"https://ir.kagoshima-u.ac.jp/record/13250/files/23501298_榎田英樹.pdf"},"version_id":"fa0b4294-21e7-4840-a913-c290f26c67b3"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"microRNA","subitem_subject_scheme":"Other"},{"subitem_subject":"膀胱癌","subitem_subject_scheme":"Other"},{"subitem_subject":"診断マーカー","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"尿路上皮癌患者尿中に存在するマイクロRNAを基点とした新規診断法の開発研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"尿路上皮癌患者尿中に存在するマイクロRNAを基点とした新規診断法の開発研究"}]},"item_type_id":"8","owner":"3","path":["80"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-05-26"},"publish_date":"2015-05-26","publish_status":"0","recid":"13250","relation_version_is_last":true,"title":["尿路上皮癌患者尿中に存在するマイクロRNAを基点とした新規診断法の開発研究"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-12-25T07:18:55.214148+00:00"}