{"created":"2023-07-25T08:13:12.290466+00:00","id":13963,"links":{},"metadata":{"_buckets":{"deposit":"c1298def-75ed-42e9-84b8-5025466e57cd"},"_deposit":{"created_by":18,"id":"13963","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"13963"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00013963","sets":["57:86"]},"author_link":["128079"],"item_5_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"119","bibliographicPageStart":"112","bibliographicVolumeNumber":"59","bibliographic_titles":[{"bibliographic_title":"International Heart Journal","bibliographic_titleLang":"en"}]}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2017-09-29"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 最終試験結果の要旨, 論文審査の要旨, 博士論文要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"According to recent studies, lung uptake of iodine-123-metaiodobenzylguanidine (123I-MIBG) is impaired in many lung diseases and low lung uptake of 123I-MIBG suggests endothelial dysfunction of the pulmonary artery.123I-MIBG scintigraphy in patients with pulmonary hypertension (PH) has not yet been clinically evaluated. We hypothesized that the lung uptake of 123I-MIBG is reduced in patients with PH and differs among PH subtypes. The purpose of the present study was to analyze the lung uptake of 123I-MIBG in patients with PH and compare it with the data obtained by echocardiography or right heart catheterization. 123I-MIBG scintigraphy was performed in 286 consecutive patients from 2003 to 2014. We enrolled 21 patients with PH and 8 control patients.The 21 patients with PH were categorized into those with pulmonary artery hypertension(PAH, n=12) and those with chronic thromboembolic pulmonary hypertension (CTEPH, n=9). The mean pulmonary artery pressure was not significantly different between patients with CTEPH and PAH (37.7 ± 6.8 versus 32.3 ± 5.3 mmHg respectively; P=0.054). There were no significant differences in any other  hemodynamic parameters between the two groups.The lung uptake of 123I-MIBG in PAH patients (early image: 1.54 ± 0.18, delayed image: 1.41 ± 0.16) was significantly lower than that of CTEPH patients (early image: 2.17 ± 0.25,P<0.0001; delayed image: 1.99 ± 0.20, P=0.0001, adjusted for ageand World Health Organization classification) and  controls(early image: 2.32 ± 0.27, P=0.0007; delayed image: 1.92 ± 0.19,P=0.0007). In conclusion, we found for the first time that the lung uptake of 123I-MIBG in patients with PAH is lower than that in patients with CTEPH and controls.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第429号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"International Heart Journal Association","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_relation_13":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"International Heart Journal"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.jstage.jst.go.jp/browse/ihj/","subitem_relation_type_select":"URI"}}]},"item_5_relation_36":{"attribute_name":"関連（hasPart）","attribute_value_mlt":[{"subitem_relation_type":"hasPart","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1536/ihj.16-629","subitem_relation_type_select":"URI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2018 by the International Heart Journal Association","subitem_rights_language":"en"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13492365","subitem_source_identifier_type":"PISSN"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"493","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:大石充】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2017-04-14"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"肥後, 建樹郎","creatorNameLang":"ja"},{"creatorName":"ヒゴ, ケンジュロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Higo, Kenjuro","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-08-10"}],"displaytype":"detail","filename":"Diss_肥後_建樹郎_ISK429_2017.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Diss_肥後_建樹郎_ISK429_2017","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/13963/files/Diss_肥後_建樹郎_ISK429_2017.pdf"},"version_id":"ad22c567-77d2-424d-bd3f-f048da95af1e"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-10"}],"displaytype":"detail","filename":"Result_Higo_Kenjuro_isk429_2017.pdf","filesize":[{"value":"135.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Result_Higo_Kenjuro_isk429_2017","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/13963/files/Result_Higo_Kenjuro_isk429_2017.pdf"},"version_id":"fc4dc37b-02ac-4215-aa00-5a0b5548170e"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-10"}],"displaytype":"detail","filename":"Comments_Higo_Kenjuro_isk429_2017.pdf","filesize":[{"value":"69.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_Higo_Kenjuro_isk429_2017","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/13963/files/Comments_Higo_Kenjuro_isk429_2017.pdf"},"version_id":"1ece59bf-15ba-4449-81df-9345e506fe24"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-10"}],"displaytype":"detail","filename":"Abstruct_肥後_建樹郎_4513810331_2017.pdf","filesize":[{"value":"100.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Abstruct_肥後_建樹郎_4513810331_2017","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/13963/files/Abstruct_肥後_建樹郎_4513810331_2017.pdf"},"version_id":"71a88378-da21-46c4-a401-527aeb9e357a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Pulmonary hypertension","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"123I-MIBG scintigraphy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Endothelial dysfunction","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Impairment of iodine-123-metaiodobenzylguanidine (123I-MIBG) uptake in patients with pulmonary artery hypertension","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Impairment of iodine-123-metaiodobenzylguanidine (123I-MIBG) uptake in patients with pulmonary artery hypertension","subitem_title_language":"en"},{"subitem_title":"肺動脈性肺高血圧症患者における肺MIBG取り込み低下","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-10-10"},"publish_date":"2017-10-10","publish_status":"0","recid":"13963","relation_version_is_last":true,"title":["Impairment of iodine-123-metaiodobenzylguanidine (123I-MIBG) uptake in patients with pulmonary artery hypertension"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T01:44:48.251035+00:00"}