{"created":"2023-07-25T08:13:12.462594+00:00","id":13967,"links":{},"metadata":{"_buckets":{"deposit":"dc3f2b40-22bb-4d1a-92d7-d33efac19766"},"_deposit":{"created_by":18,"id":"13967","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"13967"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00013967","sets":["57:86"]},"author_link":["128090"],"item_5_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"95","bibliographicPageStart":"88","bibliographicVolumeNumber":"133","bibliographic_titles":[{"bibliographic_title":"Journal of Pharmacological Sciences","bibliographic_titleLang":"en"}]}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2017-09-29"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 最終試験結果の要旨, 論文審査の要旨, 博士論文要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"We prepared a DIC model by administrating LPS to cynomolgus monkeys, and investigated its potential for evaluations of new medicines for DIC therapy. Peripheral blood mononuclear cells (PBMC) collected from cynomolgus monkeys were incubated with LPS (8 types), and TNF-α levels in the media were measured. LPS from E. coli (K-235) was most appropriate in terms of larger increases and smaller variation in TNF-α levels. PBMC from rats, cynomolgus monkeys or humans were incubated with LPS (K-235), and the TNF-α response to LPS was investigated. The response was comparable between cynomolgus monkeys and humans but small in rats. In an in vivo experiment, LPS (K-235) was administered once intravenously to cynomolgus monkeys with or without recombinant human thrombomodulin (rhTM) to investigate any changes in coagulation and fibrinolysis biomarkers and the suppressive effect of rhTM. The liver, kidney, and lung were examined histopathologically. Almost all of the changes resembled the pathophysiological status of human DIC and were suppressed by co-administration of rhTM. The DIC model resembling human DIC was established by LPS (K-235) treatment in cynomolgus monkeys, and therapeutic effect of rhTM was noted, suggesting that this model is useful in evaluations of the efficacy of new medicines for DIC therapy.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第433号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Japanese Pharmacological Society","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_relation_13":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Journal of Pharmacological Sciences"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.sciencedirect.com/journal/journal-of-pharmacological-sciences","subitem_relation_type_select":"URI"}}]},"item_5_relation_36":{"attribute_name":"関連（hasPart）","attribute_value_mlt":[{"subitem_relation_type":"hasPart","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.jphs.2017.01.005","subitem_relation_type_select":"URI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2017 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.","subitem_rights_language":"en"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"493","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":" 【指導教員:宮田篤郎】  "}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"蓑毛, 博文","creatorNameLang":"ja"},{"creatorName":"ミノモ, ヒロフミ","creatorNameLang":"ja-Kana"},{"creatorName":"Minomo, Hirofumi","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-09-04"}],"displaytype":"detail","filename":"Diss_蓑毛_博文_ISK433_2017.pdf","filesize":[{"value":"414.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Diss_蓑毛_博文_ISK433_2017","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/13967/files/Diss_蓑毛_博文_ISK433_2017.pdf"},"version_id":"b8ab2422-e0c8-4c4e-8bdb-fdab06c6d045"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-10"}],"displaytype":"detail","filename":"Result_Minomo_Hirofumi_isk433_2017.pdf","filesize":[{"value":"139.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Result_Minomo_Hirofumi_isk433_2017","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/13967/files/Result_Minomo_Hirofumi_isk433_2017.pdf"},"version_id":"6bfed40a-0ba0-4a21-86c4-593acdb93ba6"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-10"}],"displaytype":"detail","filename":"Comments_Minomo_Hirofumi_isk433_2017.pdf","filesize":[{"value":"56.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_Minomo_Hirofumi_isk433_2017","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/13967/files/Comments_Minomo_Hirofumi_isk433_2017.pdf"},"version_id":"dc9b22a8-d999-4c35-996d-fb071dd75a05"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-09-04"}],"displaytype":"detail","filename":"Abstract_蓑毛_博文_4513810340_2017.pdf","filesize":[{"value":"107.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Abstract_蓑毛_博文_4513810340_2017","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/13967/files/Abstract_蓑毛_博文_4513810340_2017.pdf"},"version_id":"322c36a9-fcde-4018-b98a-d8722555e7ef"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Thrombomodulin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"LPS","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"DIC","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Establishment of Disseminated Intravascular Coagulation (DIC) Model by a Single iv Administration of E. coli-derived Lipopolysaccharide (LPS) to Cynomolgus Monkeys and Evaluation of its Pathophysiological Status","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Establishment of Disseminated Intravascular Coagulation (DIC) Model by a Single iv Administration of E. coli-derived Lipopolysaccharide (LPS) to Cynomolgus Monkeys and Evaluation of its Pathophysiological Status","subitem_title_language":"en"},{"subitem_title":"カニクイザルを用いた大腸菌由来リポポリサッカライド(LPS)投与による播種性血管内凝固症候群(DIC)モデル作成及びその病態解析","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-10-10"},"publish_date":"2017-10-10","publish_status":"0","recid":"13967","relation_version_is_last":true,"title":["Establishment of Disseminated Intravascular Coagulation (DIC) Model by a Single iv Administration of E. coli-derived Lipopolysaccharide (LPS) to Cynomolgus Monkeys and Evaluation of its Pathophysiological Status"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T01:45:00.705865+00:00"}