{"created":"2023-07-25T08:13:16.474323+00:00","id":14048,"links":{},"metadata":{"_buckets":{"deposit":"70110b50-7ec1-418a-8df6-7c3f868dc936"},"_deposit":{"created_by":18,"id":"14048","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"14048"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00014048","sets":["57:86"]},"author_link":["128901"],"item_5_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"1114","bibliographicPageStart":"1109","bibliographicVolumeNumber":"33","bibliographic_titles":[{"bibliographic_title":"Pediatric Surgery International","bibliographic_titleLang":"en"}]}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2017-12-22"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 最終試験結果の要旨, 論文審査の要旨, 博士論文要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Purpose: Necrotizing enterocolitis (NEC) is a devastating gastrointestinal disease of premature infants. Daikenchuto, a Japanese herbal drug has several effects on the digestive system, so we investigated its preventive effects in a rat model of NEC.\nMethods: NEC was induced in newborn rats via asphyxia (100% N2 for 90 s; every 4 h) + LPS (4 mg/kg/day [administered orally on Days 0 and 1]). The effects of Daikenchuto were evaluated in 4 groups (control: 0 g/kg/day, I: 0.3 g/kg/day, II: 0.6 g/kg/day, III: 1.0 g/kg/day). Daikenchuto was administered into the stomach through a microcatheter. The incidence and severity of NEC were pathologically assessed using the NEC grade in accordance with Dovorak’s previous report. Cell positivity for inflammatory cytokine (IL-6) was also evaluated.\nResults: Daikenchuto reduced the incidence of NEC in control, Groups I, II, and III to 68.7%, 30.0%, 30.7%, and 13.3%, respectively. High dose Daikenchuto significantly improved the incidence of NEC, and the rate of IL-6 positive cells in group III was significantly lower than in the control group (p=0.04).\nConclusion: We evaluated the effect of Daikenchuto against NEC and found that it reduced the incidence rate of NEC due to a decrease in the IL-6 production.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第442号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Springer","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_relation_13":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"The final publication is available at link.springer.com"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://link.springer.com/article/10.1007%2Fs00383-017-4145-9","subitem_relation_type_select":"URI"}}]},"item_5_relation_36":{"attribute_name":"関連（hasPart）","attribute_value_mlt":[{"subitem_relation_type":"hasPart","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s00383-017-4145-9","subitem_relation_type_select":"URI"}}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"493","subitem_subject_scheme":"NDC"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"新山, 新","creatorNameLang":"ja"},{"creatorName":"シンヤマ, シン","creatorNameLang":"ja-Kana"},{"creatorName":"Shinyama, Shin","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-10-10"}],"displaytype":"detail","filename":"Diss_Isk442_2017_Shin_Shinyama.pdf","filesize":[{"value":"401.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Diss_Isk442_2017_Shin_Shinyama","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/14048/files/Diss_Isk442_2017_Shin_Shinyama.pdf"},"version_id":"5319aae7-985f-46ca-a27c-1ee4f3220487"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-01-15"}],"displaytype":"detail","filename":"Result_Shinyama_Shin_isk442_2017.pdf","filesize":[{"value":"148.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Result_Shinyama_Shin_isk442_2017","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/14048/files/Result_Shinyama_Shin_isk442_2017.pdf"},"version_id":"f6a05f1f-1aa4-4ea3-b584-4e9ef8ef34b6"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-01-15"}],"displaytype":"detail","filename":"Comments_Shinyama_Shin_isk442_2017.pdf","filesize":[{"value":"79.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_Shinyama_Shin_isk442_2017","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/14048/files/Comments_Shinyama_Shin_isk442_2017.pdf"},"version_id":"30906282-74b7-4f28-aa5f-d7ba38310151"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-04"}],"displaytype":"detail","filename":"Abstract_新山_新_4506800156_2017.pdf","filesize":[{"value":"131.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Abstract_新山_新_4506800156_2017","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/14048/files/Abstract_新山_新_4506800156_2017.pdf"},"version_id":"e93e7b6e-1f7c-442f-a17c-3107c7815fd6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"necrotizing enterocolitis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"rat model","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Daikenchuto","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"NEC grade","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-6","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"The novel preventive effect of Daikenchuto (TJ-100), a Japanese herbal drug, against neonatal necrotizing enterocolitis (NEC) model in rats.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The novel preventive effect of Daikenchuto (TJ-100), a Japanese herbal drug, against neonatal necrotizing enterocolitis (NEC) model in rats.","subitem_title_language":"en"},{"subitem_title":"新生児壊死性腸炎ラットモデルに対する大建中湯の予防効果","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-01-15"},"publish_date":"2018-01-15","publish_status":"0","recid":"14048","relation_version_is_last":true,"title":["The novel preventive effect of Daikenchuto (TJ-100), a Japanese herbal drug, against neonatal necrotizing enterocolitis (NEC) model in rats."],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T01:45:16.716590+00:00"}