{"created":"2023-07-25T08:13:31.512062+00:00","id":14404,"links":{},"metadata":{"_buckets":{"deposit":"821b63b9-4f09-449f-8556-d0845da05072"},"_deposit":{"created_by":18,"id":"14404","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"14404"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00014404","sets":["57:86"]},"author_link":["132018"],"item_5_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"172","bibliographicPageStart":"165","bibliographicVolumeNumber":"219","bibliographic_titles":[{"bibliographic_title":"Journal of Surgical Research","bibliographic_titleLang":"en"}]}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2018-04-26"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 最終試験結果の要旨, 論文審査の要旨, 博士論文要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Background: Hydrogen sulfide (H2S) has recently been reported to demonstrate both antiinflammatory and cytoprotective effects; however, its efficacy has not been well documented in large animal models. In this study, we examined whether the administration of H2S offers cytoprotective effects on renal ischemia-reperfusion injury (IRI) in a preclinical miniature swine model.\nMethods: Major histocompatibility complex-inbred, CLAWN miniature swine (n=9) underwent a right nephrectomy, followed by induction of a 120-min period of warm ischemia via placement of clamps on the left renal artery and vein. Group 1 (n=3) underwent renal ischemia \nwithout H2S administration. Groups 2 (n=3) and 3 (n=3) received Na2S (prodrug of H2S) 10 min before reperfusion of the ischemic kidneys followed by a 30-min of Na2S postreperfusion intravenously (group 2) or selective administration of Na2S via the left renalartery(group 3).IRI\n was assessed by kidney biopsies, levels of inflammatory cytokines in sera and kidney tissue.\nResults: Animals in group 1 had significantly higher serum creatinine levels compared with animals in groups 2 and 3 (P<0.01). Histology showed severe tubular damage with TUNEL-positive cells in group 1 on postoperative day 2 compared with mild damage in group 2 and minimal damage in group 3. Further more, levels of inflammatory cytokines in both serum  (interleukin-6 [IL-6], tumor necrosis factor-α, and high-mobility group box 1) and renal tissue (IL-1 and IL-6) in group 3 were markedly lower than in group 2, suggesting beneficial effects of selective Na2S administration.\nConclusions: Na2S administration, especially via an organ selective approach, appears to potentially offer cytoprotective and antiinflammatory effects following rena lIRI.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第460号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_relation_13":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Journal of Surgical Research"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.sciencedirect.com/journal/journal-of-surgical-research","subitem_relation_type_select":"URI"}}]},"item_5_relation_36":{"attribute_name":"関連（hasPart）","attribute_value_mlt":[{"subitem_relation_type":"hasPart","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.jss.2017.05.123","subitem_relation_type_select":"URI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2017 Elsevier Inc. All rights reserved.","subitem_rights_language":"en"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:山田和彦】 "}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"関島, 光裕","creatorNameLang":"ja"},{"creatorName":"セキジマ, ミツヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Sekijima, Mitsuhiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"132018","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-08-10"}],"displaytype":"detail","filename":"Diss_関島_光裕_ISK460_2018.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Diss_関島_光裕_ISK460_2018","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/14404/files/Diss_関島_光裕_ISK460_2018.pdf"},"version_id":"378b7334-696f-4a4e-b743-e9701e64ac31"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-11"}],"displaytype":"detail","filename":"Sekishima_Mitsuhiro_isk_460_2018.pdf","filesize":[{"value":"989.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Sekishima_Mitsuhiro_isk_460_2018","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/14404/files/Sekishima_Mitsuhiro_isk_460_2018.pdf"},"version_id":"90c63540-d21c-4ff1-86f2-1cb8e0915cc4"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-11"}],"displaytype":"detail","filename":"Comments_Sekishima_Mitsuhiro_isk_460_2018.pdf","filesize":[{"value":"435.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_Sekishima_Mitsuhiro_isk_460_2018","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/14404/files/Comments_Sekishima_Mitsuhiro_isk_460_2018.pdf"},"version_id":"5cc3ce2f-700f-4131-88f2-ceb25d7a099e"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-08-10"}],"displaytype":"detail","filename":"Abstract_関島_光裕_4513810303_2018.pdf","filesize":[{"value":"191.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Abstract_関島_光裕_4513810303_2018","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/14404/files/Abstract_関島_光裕_4513810303_2018.pdf"},"version_id":"7a6c0f20-c3c9-4d71-acac-8cb27442448e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Hydrogen sulfide","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Ischemia-reperfusion injury","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Large animal model","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Proinflammatory cytokines","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Hydrogen Sulfide Prevents Renal Ischemia-Reperfusion Injury in CLAWN Miniature Swine","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Hydrogen Sulfide Prevents Renal Ischemia-Reperfusion Injury in CLAWN Miniature Swine","subitem_title_language":"en"},{"subitem_title":"硫化水素によるクラウン系ミニブタ腎虚血再灌流障害抑制効果","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-07-11"},"publish_date":"2018-07-11","publish_status":"0","recid":"14404","relation_version_is_last":true,"title":["Hydrogen Sulfide Prevents Renal Ischemia-Reperfusion Injury in CLAWN Miniature Swine"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T01:46:14.623315+00:00"}