{"created":"2023-07-25T08:13:31.599288+00:00","id":14406,"links":{},"metadata":{"_buckets":{"deposit":"7a31e452-e084-4bc6-867b-103b6d22d0e8"},"_deposit":{"created_by":18,"id":"14406","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"14406"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00014406","sets":["57:86"]},"author_link":["132025"],"item_5_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"482","bibliographicPageStart":"478","bibliographicVolumeNumber":"42","bibliographic_titles":[{"bibliographic_title":"Auris Nasus Larynx","bibliographic_titleLang":"en"}]}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2018-04-04"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル(説明)","attribute_value_mlt":[{"subitem_description":"博士論文全文, 最終試験結果の要旨, 論文審査の要旨, 博士論文要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Objective: Transcutaneous immunization (TCI) is a novel route of vaccination through application of a topical vaccine antigen on the skin. Phosphorylcholine (PC) is a structural component of a variety of pathogens and anti-PC immune responses protect mice against invasive bacterial diseases. The purpose of the study was to examine the effect of TCI using PC in BALB/c mice.\nMethods: TCI was performed in BALB/c mice using PC–keyhole limpet hemocyanin (KLH) plus cholera toxin (CT). Immunogenicity was evaluated by measuring PC-specific IgG and specific IgG1, IgG2a, IgM, IgA, and secretory IgA antibodies by ELISA. The concentrations of IL-4, IL-5, IL-10, IL-12, IL-13 and IFN-γ were also measured using ELISA for mouse.\nResults: Six months after immunization, IgG after TCI using PC plus CT was significantly higher than in controls, but this was not found for IgA. In saliva, secretory IgA antibodies decreased with a peak level at 2–3 months. IgG1 was significantly higher than IgG2 after TCI. Production of IL-4 from CD4+ cells was significantly higher after TCI than in controls, whereas production of IFN-γ, IL-5, IL-12 and IL-13 was not detected in either group.\nConclusion: These results suggest that TCI using PC plus CT with BALB/c mice is a simple approach for induction of systemic and mucosal immune responses that are shifted in the Th-2 direction.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第463号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_relation_13":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Auris Nasus Larynx"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.journals.elsevier.com/auris-nasus-larynx","subitem_relation_type_select":"URI"}}]},"item_5_relation_36":{"attribute_name":"関連(hasPart)","attribute_value_mlt":[{"subitem_relation_type":"hasPart","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.anl.2015.02.008","subitem_relation_type_select":"URI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2015 Elsevier Ireland Ltd. All rights reserved.","subitem_rights_language":"en"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"492","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:黒野祐一】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2017/12/6"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"永野, 広海","creatorNameLang":"ja"},{"creatorName":"ナガノ, ヒロミ","creatorNameLang":"ja-Kana"},{"creatorName":"Nagano, Hiromi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"132025","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-10-26"}],"displaytype":"detail","filename":"Diss 永野 広海 2018年.pdf","filesize":[{"value":"856.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Diss 永野 広海 2018年","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/14406/files/Diss 永野 広海 2018年.pdf"},"version_id":"88774f8c-574e-455a-83bc-a22b3023757f"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-11"}],"displaytype":"detail","filename":"Result_Nagano_Hiromi_isk_463_2018.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Result_Nagano_Hiromi_isk_463_2018","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/14406/files/Result_Nagano_Hiromi_isk_463_2018.pdf"},"version_id":"8aa4eb1c-69a7-4f6c-a0eb-dd0f1cf8581b"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-11"}],"displaytype":"detail","filename":"Comments_Nagano_Hiromi_isk_463_2018.pdf","filesize":[{"value":"465.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_Nagano_Hiromi_isk_463_2018","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/14406/files/Comments_Nagano_Hiromi_isk_463_2018.pdf"},"version_id":"c3990b04-7eb9-49c2-9344-6e1242281625"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-11"}],"displaytype":"detail","filename":"4 Abstract__永野 広海_4510810051_2018..pdf","filesize":[{"value":"127.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"4 Abstract__永野 広海_4510810051_2018.","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/14406/files/4 Abstract__永野 広海_4510810051_2018..pdf"},"version_id":"e356a71a-76f7-44b3-b754-c86833c4023b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Transcutaneous immunization","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Phosphorylcholine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Saliva","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Secretory IgA","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Transcutaneous immunization with phosphorylcholine induces antigen-specific mucosal and systemic immune responses in BALB/cmice.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Transcutaneous immunization with phosphorylcholine induces antigen-specific mucosal and systemic immune responses in BALB/cmice.","subitem_title_language":"en"},{"subitem_title":"ホスホリルコリン経皮投与における全身および粘膜面にあたえる影響に関するマウスを用いた検討","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-07-11"},"publish_date":"2018-07-11","publish_status":"0","recid":"14406","relation_version_is_last":true,"title":["Transcutaneous immunization with phosphorylcholine induces antigen-specific mucosal and systemic immune responses in BALB/cmice."],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T01:46:21.456557+00:00"}