{"created":"2023-07-25T08:13:32.430239+00:00","id":14424,"links":{},"metadata":{"_buckets":{"deposit":"e4d67bf8-9590-4925-8c63-597eef47d65b"},"_deposit":{"created_by":18,"id":"14424","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"14424"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00014424","sets":["57:86"]},"author_link":["132091"],"item_5_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{"bibliographic_title":"Scientific Reports","bibliographic_titleLang":"en"}]}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2018-08-20"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"We examined whether orexin neurons might play a protective role against fasting- and adenosine-induced hypothermia. We first measured body temperature (BT) in orexin neuron-ablated (ORX-AB) mice and wild-type (WT) controls during 24 hours of fasting. As expected, the magnitude of BT drop and the length of time suffering from hypothermia were greater in ORX-AB mice than in WT mice. \nOrexin neurons were active just before onset of hypothermia and during the recovery period as revealed by calcium imaging in vivo using G-CaMP. We next examined adenosine-induced hypothermia via an intracerebroventricular administration of an adenosine A1 receptor agonist, N6-cyclohexyladenosine (CHA), which induced　hypothermia in both ORX-AB and WT mice. The dose of CHA required to initiate a　hypothermic response in ORX-AB mice was more than 10 times larger than the dose for WT mice. Once hypothermia was established, the recovery was seemingly slower in ORX-AB mice. Activation of orexin neurons during the recovery phase was confirmed by immunohistochemistry for c-Fos. We propose that orexin neurons play dual roles (enhancer in the induction phase and compensator during the recovery phase) in adenosine-induced hypothermia and a protective/compensatory role in fasting-induced hypothermia","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第472号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/s41598-018-21252-w","subitem_relation_type_select":"DOI"}}]},"item_5_relation_13":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Scientific Reports"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.nature.com/srep/","subitem_relation_type_select":"URI"}}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"491","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:垣花泰之】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2018/5/2"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"二木, 貴弘","creatorNameLang":"ja"},{"creatorName":"フタツキ, タカヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Futatsuki, Takahiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-09-13"}],"displaytype":"detail","filename":"Diss_二木_貴弘_ISK472_2018.pdf","filesize":[{"value":"5.7 MB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"Diss_二木_貴弘_ISK472_2018","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/14424/files/Diss_二木_貴弘_ISK472_2018.pdf"},"version_id":"04aad2d2-1e54-4794-80b2-278b7461d20c"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-09-13"}],"displaytype":"detail","filename":"Abstract_二木_貴弘_4514810228_2018.pdf","filesize":[{"value":"72.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Abstract_二木_貴弘_4514810228_2018","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/14424/files/Abstract_二木_貴弘_4514810228_2018.pdf"},"version_id":"f008b3ed-367e-4f61-b9c6-3f97373cec8a"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-09-13"}],"displaytype":"detail","filename":"Result_Futatsuki_Takahiro_isk_472_2018.pdf","filesize":[{"value":"682.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Result_Futatsuki_Takahiro_isk_472_2018","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/14424/files/Result_Futatsuki_Takahiro_isk_472_2018.pdf"},"version_id":"bd59f320-c5b5-49d3-881c-a29811e90515"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-09-13"}],"displaytype":"detail","filename":"Comments_Futatsuki_Takahiro_isk_472_2018.pdf","filesize":[{"value":"347.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_Futatsuki_Takahiro_isk_472_2018","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/14424/files/Comments_Futatsuki_Takahiro_isk_472_2018.pdf"},"version_id":"c05eb1b4-b0b5-46c8-a4f0-cf58601454d1"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Involvement of orexin neurons in fasting- and central adenosine-induced hypothermia","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Involvement of orexin neurons in fasting- and central adenosine-induced hypothermia","subitem_title_language":"en"},{"subitem_title":"飢餓およびアデノシン誘発低体温へのオレキシン神経の関与","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-09-13"},"publish_date":"2018-09-13","publish_status":"0","recid":"14424","relation_version_is_last":true,"title":["Involvement of orexin neurons in fasting- and central adenosine-induced hypothermia"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T01:47:57.158678+00:00"}