{"created":"2023-07-25T08:13:34.571817+00:00","id":14455,"links":{},"metadata":{"_buckets":{"deposit":"d1976bbd-1da9-4ef8-93cb-2b59a1b0857d"},"_deposit":{"created_by":24,"id":"14455","owners":[24],"pid":{"revision_id":0,"type":"depid","value":"14455"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00014455","sets":["228:230:5871","57:58:59"]},"author_link":["132201","132205","132202","132206","132197","132203","132204","132200","132196","132198","132199"],"item_7_alternative_title_18":{"attribute_name":"別言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"本邦離島住民における血清ドコサヘキサエン酸と認知機能との関連について"}]},"item_7_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-3","bibliographicPageEnd":"10","bibliographicPageStart":"1","bibliographicVolumeNumber":"67","bibliographic_titles":[{"bibliographic_title":"鹿児島大学医学雑誌"},{"bibliographic_title":"Medical journal of Kagoshima University","bibliographic_titleLang":"en"}]}]},"item_7_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2015-04"}]},"item_7_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Backgrounds: Docosahexaenoic acid (DHA), which is mainly derived from marine fish, is suspected to reduce the risk of dementia and cognitive decline. The associations of fish consumption and DHA with the scores of Kana Pick-out test (KPT), a cognitive function test to detect pre-dementia, were examined in a remote island of Kagoshima, Japan.\nSubjects and Methods: As a part of an annual health checkup of residents, a questionnaire survey, hair sample collection, and the KPT were conducted in a remote island of Kagoshima during September and October, 2007. Out of 1,188 residents taking a health checkup, 505 (224 men and 281 women, age 30-69), who received all examinations, were analyzed. Among of them, serum samples from 424 subjects were available for a free fatty acid assay. Hair mercury level was analyzed by cold vapour atomic absorption method, and serum free fatty acid level was measured by gas chromatography. Multivariate linear regression analysis was used to calculate the age-, sex-, and education-level-adjusted KPT scores among different levels of mercury and the ratios DHA to arachidonic acid (AA).\nResults: The average of KPT score in women (38.1) was higher than that of men (35.0, p<0.001). The scores decreased with age (p<0.001) and lower education levels (p<0.001) in both men and women. After adjusting for the effects of age, sex, and education level, KPT score was positively related to the DHA/AA (p for trend = 0.034) in the subjects under the age of 60 but this tendency was not observed in those aged 60 or older.\nConclusion: The present study suggested a potential benefit of DHA on cognitive function in the subjects under the age of 60 but further studies for the elderly people are required.","subitem_description_type":"Other"},{"subitem_description":"背景：魚介類から主に摂取されるドコサヘキサエン酸（DHA）には、認知症のリスクおよび認知機能低下を予防する可能性があることが報告されている。本研究では、鹿児島の離島地域住民を対象として、早期認知症のスクリーニングとしても用いられるかなひろいテストの得点と魚介類の摂取量および血清DHA 値との関連を検討した。\n対象と方法： 鹿児島県の離島において、2007 年9 月、10 月に住民健康診断を受診した者を対象とし、魚介類の摂取などに関する質問調査、毛髪の採取およびかなひろいテストを健診会場で行った。1,188 名の受診者の中で、すべての検査が実施できた505 名（男性224 名、女性281 名、年齢30-69 歳）を今回の解析対象とした。さらにその中で血清中の不飽和脂肪酸が測定できた者は424 名であった。毛髪水銀の測定は冷蒸気原子吸光法で行い、血清中不飽和脂肪酸の測定はガスクロマトグラフィーを用いて行った。年齢、性および教育歴を調整し、かなひろいテスト得点と、魚食量、毛髪水銀値および血清DHA（アラキドン酸 [AA] との比）などとの関連について多変量回帰分析を行った。\n結果: かなひろい得点の平均値は女性38.1、男性35.0 で、女性の方が高かった（P 値：<0.001）。男女とも、かなひろい得点は年齢とともに減少し（P 値：<0.001）、教育歴（年数）と正の関連を示した（P 値：<0.001）。これらの要因を調整した結果、60 歳未満では、DHA:AA 比とかなひろいテスト得点に有意な正の関連を認めた（傾向性のP 値：0.034）が、60 歳以上ではそのような傾向は見られなかった。\n結論: 本研究結果により、60 歳未満の者においては、DHA による認知機能改善効果の可能性が示唆されたが、高齢者における有用性はさらなる検討が必要と思われる。","subitem_description_type":"Other"}]},"item_7_full_name_3":{"attribute_name":"別言語の著者","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"安藤, 哲夫"}]},{"nameIdentifiers":[{}],"names":[{"name":"藤山, りか"}]},{"nameIdentifiers":[{}],"names":[{"name":"上床, 太心"}]},{"nameIdentifiers":[{}],"names":[{"name":"秋葉, 澄伯"}]},{"nameIdentifiers":[{}],"names":[{"name":"郡山, 千早"}]}]},"item_7_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学"}]},"item_7_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03685063","subitem_source_identifier_type":"ISSN"}]},"item_7_source_id_9":{"attribute_name":"NII書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN00040104","subitem_source_identifier_type":"NCID"}]},"item_7_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"498","subitem_subject_scheme":"NDC"}]},"item_7_text_24":{"attribute_name":"公開者よみ","attribute_value_mlt":[{"subitem_text_value":"カゴシマ ダイガク"}]},"item_7_text_25":{"attribute_name":"公開者別名","attribute_value_mlt":[{"subitem_text_value":"Kagoshima University"}]},"item_7_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"DAVID, Juliet"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ANDO, Tetsuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"FUJIYAMA, Rika"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"UWATOKO, Futoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"AKIBA, Suminori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KORIYAMA, Chihaya"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-12-06"}],"displaytype":"detail","filename":"AN00040104_67_p1-10.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN00040104_67_p1-10","url":"https://ir.kagoshima-u.ac.jp/record/14455/files/AN00040104_67_p1-10.pdf"},"version_id":"3b2a6061-a49d-4cbe-8f9d-1a7e8669f965"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Cognitive Impairment","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Dementia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Docosahexaenoic acid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Fish consumption","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Kana Pick-out Test","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Serum Docosahexaenoic Acid and Cognitive Impairment of Japanese Residents in a Remote Island","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Serum Docosahexaenoic Acid and Cognitive Impairment of Japanese Residents in a Remote Island"}]},"item_type_id":"7","owner":"24","path":["59","5871"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-12-06"},"publish_date":"2018-12-06","publish_status":"0","recid":"14455","relation_version_is_last":true,"title":["Serum Docosahexaenoic Acid and Cognitive Impairment of Japanese Residents in a Remote Island"],"weko_creator_id":"24","weko_shared_id":24},"updated":"2023-09-01T11:23:21.854999+00:00"}