@article{oai:ir.kagoshima-u.ac.jp:00014458,
 author = {阿部, 正治 and 猪俣, 美穂 and 吉嶺, 陽仁 and 古城, 卓真 and 村岡, 良朗 and 吉嶺, 陽造 and 小山田, 美紀 and 福元, まゆみ and 屋, 万栄 and 徳永, 公紀 and 野﨑, 剛 and 井戸, 章雄},
 issue = {1-3},
 journal = {鹿児島大学医学雑誌, Medical journal of Kagoshima University},
 month = {Dec},
 note = {Purpose: Steroid therapy has been established for pediatric patients with Henoch-Schönlein purpura nephritis (HSPN). Therefore, adult patients with HSPN have been treated with steroid alone or combined with tonsillectomy. However the effect of steroid therapy with or without tonsillectomy in adult patients remains to be determined. This study aims to evaluate whether steroid therapy with or without tonsillectomy affects the clinical course of adult HSPN patients.
Methods: We retrospectively investigated nine adult patients, including five men, with biopsy-proven HSPN from 2006 to 2012, followed by observation for more than 12 months (range: 19 to 97 months).
Results: The median age of the patients was 36 years (range 20 to 72) at the time of renal biopsy. Three patients received steroid pulse therapy combined with tonsillectomy, and three received steroid therapy. In three additional patients, one was treated with an angiotensin II receptor blocker (ARB) and dilazep, one was treated with a Ca blocker, and the other did not receive any medication. Except for the patient receiving the Ca blocker, eight patients were in remission throughout the observation period. Notably, two of three patients treated with steroid pulse therapy and tonsillectomy and one of three with steroid exhibited a rapid decrease in urinary excretion of protein, resulting in remission within a year.
Conclusions: All patients receiving steroid therapy with or without tonsillectomy were in remission. These results suggest that steroid therapy alone, regardless of tonsillectomy, is likely effective in adult patients with HSPN.},
 pages = {27--32},
 title = {成人紫斑病性腎炎に対するステロイド療法の検討},
 volume = {67},
 year = {2015}
}