@article{oai:ir.kagoshima-u.ac.jp:00014464,
 author = {牛飼, 美晴 and 川口, 博明 and 阿部, 正治 and 堀内, 正久},
 journal = {鹿児島大学医学雑誌, Medical journal of Kagoshima University},
 month = {Dec},
 note = {Purpose: We evaluated the influence of ethanol intake on pathophysiology of diabetes using db mice, an animal model of type 2 diabetes.
Methods: The concentration of ethanol used was evaluated by the preference test. Then, 6 homozygotes (db) as diabetes and 6 heterozygotes as non-diabetes were used. The mice were randomly separated to water group and ethanol group (5% ethanol was supplied), then they were kept for 9 weeks. Finally, they were anesthetized by after 6 h fasting, and organs were removed after blood collection from the heart.
Results: The ethanol concentration used was determined as 5%, which was not discriminated from water by db and control mice. Mice supplied with ethanol showed significantly lower intake of food, which was compensated by the energy from ethanol. dbethanol (EtOH) mice showed lower plasma glucose and HbA1c, indicating that glucose metabolism was not aggravated. On the other hand, in biochemical and histological examinations of liver, db-EtOH showed significantly higher content of triglycerides in association with vacuolization change, possibly due to fat accumulation in the liver.
Conclusions: Low concentration of ethanol aggravated fatty liver in db mice, in regardless of aggravation of glycemic control. This may indicate that fatty liver is a significant marker to consider alcohol intake in patients with diabetes.},
 pages = {1--8},
 title = {エタノールの糖尿病病態への影響：レプチン受容体欠損マウスを用いた検討},
 volume = {69},
 year = {2017}
}