{"created":"2023-07-25T08:13:35.165494+00:00","id":14464,"links":{},"metadata":{"_buckets":{"deposit":"eecb7f7b-030e-4a3d-af72-1b3618b4dccf"},"_deposit":{"created_by":24,"id":"14464","owners":[24],"pid":{"revision_id":0,"type":"depid","value":"14464"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00014464","sets":["228:230:5873","57:58:59"]},"author_link":["132353","132346","132354","132347","132349","132352","132351","132348","132350","132345","132356","132355"],"item_7_alternative_title_19":{"attribute_name":"タイトルよみ","attribute_value_mlt":[{"subitem_alternative_title":"エタノール ノ トウニョウビョウ ビョウタイ エノ エイキョウ : レプチン ジュヨウタイ ケッソン マウス オ モチイタ ケントウ"}]},"item_7_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-12","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"8","bibliographicPageStart":"1","bibliographicVolumeNumber":"69","bibliographic_titles":[{"bibliographic_title":"鹿児島大学医学雑誌"},{"bibliographic_title":"Medical journal of Kagoshima University","bibliographic_titleLang":"en"}]}]},"item_7_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2017-07"}]},"item_7_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Purpose: We evaluated the influence of ethanol intake on pathophysiology of diabetes using db mice, an animal model of type 2 diabetes.\nMethods: The concentration of ethanol used was evaluated by the preference test. Then, 6 homozygotes (db) as diabetes and 6 heterozygotes as non-diabetes were used. The mice were randomly separated to water group and ethanol group (5% ethanol was supplied), then they were kept for 9 weeks. Finally, they were anesthetized by after 6 h fasting, and organs were removed after blood collection from the heart.\nResults: The ethanol concentration used was determined as 5%, which was not discriminated from water by db and control mice. Mice supplied with ethanol showed significantly lower intake of food, which was compensated by the energy from ethanol. dbethanol (EtOH) mice showed lower plasma glucose and HbA1c, indicating that glucose metabolism was not aggravated. On the other hand, in biochemical and histological examinations of liver, db-EtOH showed significantly higher content of triglycerides in association with vacuolization change, possibly due to fat accumulation in the liver.\nConclusions: Low concentration of ethanol aggravated fatty liver in db mice, in regardless of aggravation of glycemic control. This may indicate that fatty liver is a significant marker to consider alcohol intake in patients with diabetes.","subitem_description_type":"Other"}]},"item_7_full_name_2":{"attribute_name":"著者よみ","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"ウシカイ, ミハル"}]},{"nameIdentifiers":[{}],"names":[{"name":"カワグチ, ヒロアキ"}]},{"nameIdentifiers":[{}],"names":[{"name":"アベ, マサハル"}]},{"nameIdentifiers":[{}],"names":[{"name":"ホリウチ, マサヒサ"}]}]},"item_7_full_name_3":{"attribute_name":"別言語の著者","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"USHIKAI, Miharu"}]},{"nameIdentifiers":[{}],"names":[{"name":"KAWAGUCHI, Hiroaki"}]},{"nameIdentifiers":[{}],"names":[{"name":"ABE, Masaharu"}]},{"nameIdentifiers":[{}],"names":[{"name":"HORIUCHI, Masahisa"}]}]},"item_7_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学"}]},"item_7_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03685063","subitem_source_identifier_type":"ISSN"}]},"item_7_source_id_9":{"attribute_name":"NII書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN00040104","subitem_source_identifier_type":"NCID"}]},"item_7_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"493","subitem_subject_scheme":"NDC"}]},"item_7_text_24":{"attribute_name":"公開者よみ","attribute_value_mlt":[{"subitem_text_value":"カゴシマ ダイガク"}]},"item_7_text_25":{"attribute_name":"公開者別名","attribute_value_mlt":[{"subitem_text_value":"Kagoshima University"}]},"item_7_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"牛飼, 美晴"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"川口, 博明"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"阿部, 正治"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"堀内, 正久"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-12-10"}],"displaytype":"detail","filename":"AN00040104_69_p1-8.pdf","filesize":[{"value":"912.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN00040104_69_p1-8","url":"https://ir.kagoshima-u.ac.jp/record/14464/files/AN00040104_69_p1-8.pdf"},"version_id":"18c372c5-d96d-4f90-b810-75722efafd7d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"diabetes","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"alcohol","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"fatty liver","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"energy intake","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"エタノールの糖尿病病態への影響：レプチン受容体欠損マウスを用いた検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"エタノールの糖尿病病態への影響：レプチン受容体欠損マウスを用いた検討"},{"subitem_title":"Effects of ethanol intake on pathophysiology of diabetes: a study using db mice, an animal model of diabetes with a leptin receptor deficiency","subitem_title_language":"en"}]},"item_type_id":"7","owner":"24","path":["59","5873"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-12-10"},"publish_date":"2018-12-10","publish_status":"0","recid":"14464","relation_version_is_last":true,"title":["エタノールの糖尿病病態への影響：レプチン受容体欠損マウスを用いた検討"],"weko_creator_id":"24","weko_shared_id":-1},"updated":"2023-09-01T11:23:10.049521+00:00"}