{"created":"2023-07-25T08:13:39.131172+00:00","id":14532,"links":{},"metadata":{"_buckets":{"deposit":"d92d5474-49fc-486a-9403-8ab9ab98ec87"},"_deposit":{"created_by":18,"id":"14532","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"14532"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00014532","sets":["57:86"]},"author_link":["132661"],"item_5_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"E240","bibliographicPageStart":"E234","bibliographicVolumeNumber":"128","bibliographic_titles":[{"bibliographic_title":"The Laryngoscope","bibliographic_titleLang":"en"}]}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2019-01-20"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Objectives/Hypothesis: Intranasal immunization with phosphorylcholine (PC) is known to reduce IgE production. However, its effects on the occurrence of allergic rhinitis (AR) are unknown.\nObjectives: This study was performed to evaluate the effects of PC-keyhole limpet hemocyanin (PC-KLH) and to examine the effects on the occurrence of AR in a murine model of AR.\nStudy Design: In vivo study using an animal model.\nMethods: Forty-five female BALB/c mice were divided into 3 groups; those pretreated with intranasal administration of PC-keyhole limpet hemocyanin (PC-KLH) followed by intra-peritoneal sensitization and nasal challenge with ovalbumin (OVA) (Group A), those untreated with PC-KLH followed by sensitization and nasal challenge with OVA (Group B), and those untreated with PC-KLH or OVA as a control (Group C). Nasal symptoms, allergic inflammation in the nasal mucosa, OVA specific IgE production, and cytokine profile were compared among those three groups. Further, dendritic cells (DCs) were isolated from splenic cells and PC-KLH-stimulated IL-12p40 production was measured.\nResults: The mice pretreated with PC-KLH showed lower allergic nasal symptoms and inflammation compared to untreated mice. The levels of total IgE and OVA-specific IgE in serum, and IL-4 production by nasal and splenic CD4+ T cells were significantly reduced by PC-KLH pretreatment. Furthermore, IL-12p40 production by DCs was induced by PC-KLH in a dose-dependent manner.\nConclusion: Intranasal administration of PC-KLH suppressed allergic inflammation in nasal mucosa and antigen-specific IgE production by down regulating Th2-type immune response. Intranasal immunization with PC might be useful to prevent AR and upper airway bacterial infection.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"乙総論第33号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"John Wiley & Sons, Inc.","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1002/lary.27030","subitem_relation_type_select":"DOI"}}]},"item_5_relation_13":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"The Laryngoscope"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://onlinelibrary.wiley.com/journal/15314995#pane-01cbe741-499a-4611-874e-1061f1f4679e01","subitem_relation_type_select":"URI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2017 The American Laryngological, Rhinological and Otological Society, Inc.","subitem_rights_language":"en"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"492","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:黒野祐一】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2018-10-03"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"宮下, 圭一","creatorNameLang":"ja"},{"creatorName":"ミヤシタ, ケイイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Miyashita, Keiichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"132661","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-10-01"}],"displaytype":"detail","filename":"Diss_宮下_圭一_ ISKr33_ 2018.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Diss_宮下_圭一_ ISKr33_ 2018","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/14532/files/Diss_宮下_圭一_ ISKr33_ 2018.pdf"},"version_id":"979ef5ab-b8aa-426e-9ea9-d16203207f8f"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-02-19"}],"displaytype":"detail","filename":"Abstract_宮下_圭一_TO_2018.pdf","filesize":[{"value":"153.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Abstract_宮下_圭一_TO_2018","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/14532/files/Abstract_宮下_圭一_TO_2018.pdf"},"version_id":"443e4169-62a6-4226-bf9d-d7d998a0ff9f"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-01-28"}],"displaytype":"detail","filename":"Result_Miyashita_Keiichi_isk_33_2019.pdf","filesize":[{"value":"833.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Result_Miyashita_Keiichi_isk_33_2019","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/14532/files/Result_Miyashita_Keiichi_isk_33_2019.pdf"},"version_id":"d2ed42c5-65af-468b-b22d-dd7b22b7c11e"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-01-28"}],"displaytype":"detail","filename":"Comments_Miyashita_Keiichi_isk_33_2019.pdf","filesize":[{"value":"473.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_Miyashita_Keiichi_isk_33_2019","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/14532/files/Comments_Miyashita_Keiichi_isk_33_2019.pdf"},"version_id":"504afdad-576f-44eb-a0b8-4bc32ea98a0c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"allergic rhinitis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"phosphorylcholine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"NALT","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"dendritic cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-4","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-12","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Intranasal Immunization with Phosphorylcholine Suppresses Allergic Rhinitis in Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Intranasal Immunization with Phosphorylcholine Suppresses Allergic Rhinitis in Mice","subitem_title_language":"en"},{"subitem_title":"ホスホリルコリン経鼻投与によるアレルギー性鼻炎発症の抑制","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-01-28"},"publish_date":"2019-01-28","publish_status":"0","recid":"14532","relation_version_is_last":true,"title":["Intranasal Immunization with Phosphorylcholine Suppresses Allergic Rhinitis in Mice"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T01:49:04.529958+00:00"}