{"created":"2023-07-25T08:13:44.400724+00:00","id":14633,"links":{},"metadata":{"_buckets":{"deposit":"d0c7c2c5-57fb-41b7-bd30-edd769c51136"},"_deposit":{"created_by":18,"id":"14633","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"14633"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00014633","sets":["57:86"]},"author_link":["133100"],"item_5_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019","bibliographicIssueDateType":"Issued"},"bibliographicVolumeNumber":"17","bibliographic_titles":[{"bibliographic_title":"Thrombosis Journal","bibliographic_titleLang":"en"}]}]},"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2019-03-07","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2019-03-25"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Background: Nuclear histone proteins are released into the extracellular space, and act as major mediators of coagulopathy and remote organ failure in septic animals. However, the circulating histone levels in septic patients have not been precisely quantified.\nMethods: Using a novel enzyme-linked immunosorbent assay for histone H3 detection, we measured the serum histone H3 levels in 85 patients admitted to the intensive care unit because of infectious diseases. We then evaluated the associations of circulating histone H3 levels with organ failure, coagulopathy, and mortality.\nResults: Circulating histone H3 levels were significantly higher in patients with coagulopathy, and were positively correlated with numbers of organ failures. Circulating histone H3 levels were also associated with fatal outcome. Receiver-operating characteristic analyses revealed that the predictive performance of circulating histone H3 levels for mortality was higher than that of conventional inflammatory markers, including white blood cell count, C-reactive protein, and cell-free DNA.\nConclusions: Circulating histone H3 levels are associated with coagulopathy, multiple organ failure, and death in patients requiring intensive care because of infectious diseases.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第498号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"BMC","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1186/s12959-018-0190-4","subitem_relation_type_select":"DOI"}}]},"item_5_relation_13":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Thrombosis Journal"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://thrombosisjournal.biomedcentral.com/","subitem_relation_type_select":"URI"}}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"493","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:垣花泰之】 "}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2019-02-06"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"横山, 弥生","creatorNameLang":"ja"},{"creatorName":"ヨコヤマ, ヤヨイ","creatorNameLang":"ja-Kana"},{"creatorName":"Yokoyama, Yayoi","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-04-17"}],"displaytype":"detail","filename":"Diss_横山_弥生_ISK498_2018.pdf","filesize":[{"value":"940.3 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"Diss_横山_弥生_ISK498_2018","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/14633/files/Diss_横山_弥生_ISK498_2018.pdf"},"version_id":"4c29a31e-f270-4062-ad2f-9dff19787b43"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-04-17"}],"displaytype":"detail","filename":"Abstract_横山_弥生_4514810371_2018.pdf","filesize":[{"value":"133.9 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kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_Yokoyama_Yayoi_isk_498","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/14633/files/Comments_Yokoyama_Yayoi_isk_498.pdf"},"version_id":"2e69e058-4629-497b-8bab-287c1104a1a5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Histone","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Sepsis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Coagulopathy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Organ failure","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Circulating histone H3 levels in septic patients are associated with coagulopathy, multiple organ failure, and death: a single-center observational study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Circulating histone H3 levels in septic patients are associated with coagulopathy, multiple organ failure, and death: a single-center observational study","subitem_title_language":"en"},{"subitem_title":"敗血症患者の循環ヒストンH3レベルは、凝固障害、多臓器不全、および死亡と関連している : 単一施設観察研究","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-04-17"},"publish_date":"2019-04-17","publish_status":"0","recid":"14633","relation_version_is_last":true,"title":["Circulating histone H3 levels in septic patients are associated with coagulopathy, multiple organ failure, and death: a single-center observational study"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T01:49:34.332095+00:00"}