@phdthesis{oai:ir.kagoshima-u.ac.jp:00014641,
 author = {本庄, 希江 and Honjo, Kie},
 month = {},
 note = {博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨, The Purkinje cell protein 4/peptide 19 (PCP4/PEP19) is a novel breast cancer cell expressing peptide, originally found in the neural cells as an anti-apoptotic factor, could inhibit cell apoptosis and enhance cell migration and invasion in human breast cancer cell lines. The expression of PCP4/PEP19 is induced by estrogens in estrogen receptor-positive (ER+) MCF-7 cells but also highly expressed in ER- SK-BR-3 cells. In this study, we investigated the effects of PCP4/PEP19 on aromatase gene expression in MCF-7 and SK-BR-3 human breast cancer cells. In SK-BR-3 cells but not in MCF-7 cells, PCP4/PEP19 knockdown by siRNA silencing decreased the aromatase expression in gene transcriptional level. When PCP4/PEP19 was overexpressed by CMV promoterdriven PCP4/PEP19 expressing plasmid transfection, aromatase gene transcription increased in SK-BR-3 cells. This aromatase gene transcription is mainly mediated through promoter region PI.1, which is usually active in the placental tissue but not in the breast cancer tissue. These results indicate a new function of PCP4/PEP19 that would enhance aromatase gene upregulation to supply estrogens in heterogeneous cancer microenvironment.},
 school = {鹿児島大学},
 title = {PCP4/PEP19 Upregulates Aromatase Gene Expression via CYP19A1 Promoter I.1 in Human Breast Cancer SK-BR-3 Cells},
 year = {2018},
 yomi = {ホンジョウ, キエ}
}