{"created":"2023-07-25T08:13:44.746608+00:00","id":14641,"links":{},"metadata":{"_buckets":{"deposit":"d1d98174-57de-45d4-9f59-da34514f6880"},"_deposit":{"created_by":18,"id":"14641","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"14641"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00014641","sets":["57:86"]},"author_link":["133124"],"item_5_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"51","bibliographicPageEnd":"29633","bibliographicPageStart":"29619","bibliographicVolumeNumber":"9","bibliographic_titles":[{"bibliographic_title":"Oncotarget","bibliographic_titleLang":"en"}]}]},"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2019-03-07","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2019-03-25"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"The Purkinje cell protein 4/peptide 19 (PCP4/PEP19) is a novel breast cancer cell expressing peptide, originally found in the neural cells as an anti-apoptotic factor, could inhibit cell apoptosis and enhance cell migration and invasion in human breast cancer cell lines. The expression of PCP4/PEP19 is induced by estrogens in estrogen receptor-positive (ER+) MCF-7 cells but also highly expressed in ER- SK-BR-3 cells. In this study, we investigated the effects of PCP4/PEP19 on aromatase gene expression in MCF-7 and SK-BR-3 human breast cancer cells. In SK-BR-3 cells but not in MCF-7 cells, PCP4/PEP19 knockdown by siRNA silencing decreased the aromatase expression in gene transcriptional level. When PCP4/PEP19 was overexpressed by CMV promoterdriven PCP4/PEP19 expressing plasmid transfection, aromatase gene transcription increased in SK-BR-3 cells. This aromatase gene transcription is mainly mediated through promoter region PI.1, which is usually active in the placental tissue but not in the breast cancer tissue. These results indicate a new function of PCP4/PEP19 that would enhance aromatase gene upregulation to supply estrogens in heterogeneous cancer microenvironment.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第506号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Oncotarget","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.18632/oncotarget.25651","subitem_relation_type_select":"DOI"}}]},"item_5_relation_13":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Oncotarget"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.oncotarget.com/","subitem_relation_type_select":"URI"}}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"494","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:中村典史】 "}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2018-09-05"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"本庄, 希江","creatorNameLang":"ja"},{"creatorName":"ホンジョウ, キエ","creatorNameLang":"ja-Kana"},{"creatorName":"Honjo, Kie","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-04-19"}],"displaytype":"detail","filename":"Diss_本庄_希江_ISK506_2018.pdf","filesize":[{"value":"5.5 MB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"Diss_本庄_希江_ISK506_2018","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/14641/files/Diss_本庄_希江_ISK506_2018.pdf"},"version_id":"075d0a03-0182-43b2-8741-166491098cac"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-04-19"}],"displaytype":"detail","filename":"Abstract_本庄_希江_4515810151_2018.pdf","filesize":[{"value":"92.8 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kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_Honjyo_Kie_isk_506","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/14641/files/Comments_Honjyo_Kie_isk_506.pdf"},"version_id":"b1e71fe7-11d0-4ba1-88c8-1bf06c91eb08"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"PCP4/PEP19","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"breast cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"aromatase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"intratumoral heterogeneity","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"PCP4/PEP19 Upregulates Aromatase Gene Expression via CYP19A1 Promoter I.1 in Human Breast Cancer SK-BR-3 Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"PCP4/PEP19 Upregulates Aromatase Gene Expression via CYP19A1 Promoter I.1 in Human Breast Cancer SK-BR-3 Cells","subitem_title_language":"en"},{"subitem_title":"ヒト乳癌細胞株SK-BR-3において、PCP4/PEP19はCYP19A1 promoter I.1を介してaromatase遺伝子発現を亢進する。","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-04-19"},"publish_date":"2019-04-19","publish_status":"0","recid":"14641","relation_version_is_last":true,"title":["PCP4/PEP19 Upregulates Aromatase Gene Expression via CYP19A1 Promoter I.1 in Human Breast Cancer SK-BR-3 Cells"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T01:49:52.602400+00:00"}