{"created":"2023-07-25T08:13:55.775433+00:00","id":14845,"links":{},"metadata":{"_buckets":{"deposit":"ed413366-d299-4ff3-957b-d857c51d33a9"},"_deposit":{"created_by":18,"id":"14845","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"14845"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00014845","sets":["57:86"]},"author_link":["134333"],"item_5_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"920","bibliographicPageStart":"915","bibliographicVolumeNumber":"503","bibliographic_titles":[{"bibliographic_title":"Biochemical and Biophysical Research Communications","bibliographic_titleLang":"en"}]}]},"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2019-05-15","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2019-05-31"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Chorea-acanthocytosis (ChAc) is an autosomal recessive hereditary disease characterized by neurodegeneration in the striatum and acanthocytosis caused by loss-of-function mutations in the Vacuolar Protein Sorting 13 Homolog A (VPS13A) gene, which encodes chorein. We previously produced a ChAc-model mouse with a homozygous deletion of exons 60–61 in Vps13a, which corresponded to the human disease mutation. We found that male ChAc-model mice exhibited complete infertility as a result of severely diminished sperm motility. Immunocytochemical study revealed that chorein-like immunoreactivity is abundant only in the midpiece, mitochondria-rich region, of the sperm of wild type mice. They showed no significant differences from wild types in terms of the adenosine 5′-triphosphate (ATP) concentration of their sperm, sperm count, or sexual activity. Electron microscopy revealed abnormal ultrastructural morphology of the mitochondria in the midpiece of sperm from ChAc-model mice. These results suggest that chorein is essential in mouse sperm for the maintenance of ultrastructural mitochondrial morphology and sperm motility.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第510号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.bbrc.2018.06.096","subitem_relation_type_select":"DOI"}}]},"item_5_relation_13":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Biochemical and Biophysical Research Communications"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.sciencedirect.com/journal/biochemical-and-biophysical-research-communications","subitem_relation_type_select":"URI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2018 Elsevier Inc. All rights reserved.","subitem_rights_language":"en"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:浅川明弘】 "}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2019-01-09"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"永田, 青海","creatorNameLang":"ja"},{"creatorName":"ナガタ, オオミ","creatorNameLang":"ja-Kana"},{"creatorName":"Nagata, Omi","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-09-27"}],"displaytype":"detail","filename":"Diss_永田_青海_ISK510_2019.pdf","filesize":[{"value":"23.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Diss_永田_青海_ISK510_2019","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/14845/files/Diss_永田_青海_ISK510_2019.pdf"},"version_id":"9d4ae321-133b-4c19-83e8-2a5723f1838c"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-09-27"}],"displaytype":"detail","filename":"Abstract_永田_青海_4513800129_2018.pdf","filesize":[{"value":"157.8 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kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_Nagata_Omi_isk_510","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/14845/files/Comments_Nagata_Omi_isk_510.pdf"},"version_id":"2110a888-3abf-43c6-8ce0-95ec99c39db1"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Chorea-acanthocytosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ChAc-model mouse","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"male infertility","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"asthenozoospermia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Vps13a","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"chorein","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mitochondria","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Mouse model of chorea-acanthocytosis exhibits male infertility caused by impaired sperm motility as a result of ultrastructural morphological abnormalities in the mitochondrial sheath in the sperm midpiece","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Mouse model of chorea-acanthocytosis exhibits male infertility caused by impaired sperm motility as a result of ultrastructural morphological abnormalities in the mitochondrial sheath in the sperm midpiece","subitem_title_language":"en"},{"subitem_title":"有棘赤血球舞踏病モデルマウスは、精子中片部のミトコンドリア鞘の超微細構造異常を原因とした精子の運動障害により、雄性不妊を呈する","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-07-23"},"publish_date":"2019-07-23","publish_status":"0","recid":"14845","relation_version_is_last":true,"title":["Mouse model of chorea-acanthocytosis exhibits male infertility caused by impaired sperm motility as a result of ultrastructural morphological abnormalities in the mitochondrial sheath in the sperm midpiece"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T01:50:10.916999+00:00"}