{"created":"2023-07-25T08:13:56.214163+00:00","id":14852,"links":{},"metadata":{"_buckets":{"deposit":"3f3b5c2b-0ee4-4b2a-b24c-74506552a483"},"_deposit":{"created_by":18,"id":"14852","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"14852"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00014852","sets":["57:86"]},"author_link":["134356"],"item_5_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"1518","bibliographicPageStart":"1509","bibliographicVolumeNumber":"34","bibliographic_titles":[{"bibliographic_title":"Heart and Vessels","bibliographic_titleLang":"en"}]}]},"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2019-07-08","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2019-07-16"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Screening and early detection of pulmonary arterial hypertension (PAH) in connective tissue disease (CTD) is currently recommended for early treatment. Exercise induced pulmonary hypertension (EIPH) is thought to be a potential risk of developing resting pulmonary hypertension. However, accurately diagnosis of EIPH is needed hemodynamics by right heart catheterization during exercise. Therefore, we compared various parameters of EIPH group with non-EIPH group in patients with CTD. This study aimed to investigate non-invasive predictors of EIPH. A total of 162 consecutive patients with CTD who received screening of PAH was studied. Thirty-four patients with suspected PAH received right heart catheterization (RHC) at rest. Twenty-four patients without PAH underwent RHC during exercise, and they were divided into the EIPH group (n = 7) and the non-EIPH group (n = 17). Exercise tolerance such as 6-minute walk distance and peak VO2/kg in the EIPH group was lower than that in the non-EIPH group. For Hemodynamics, pulmonary artery pressure, right atrial pressure, and vascular resistance in the EIPH group were significantly higher than those in the non-EIPH group. In echocardiography, RV Tei index in the EIPH group was significantly higher than that in the non-EIPH group (EIPH vs non-EIPH = 0.42 [0.41, 0.47] vs 0.25 [0.20, 0.32], P=0.007). The receiver operating characteristics curve showed a cut-off value of RV Tei index (0.41) with a sensitivity of 0.857 and specificity of 0.882. In conclusion, RV Tei index might be a feasible predictor of EIPH in patients with CTD.\n\n\nSunao Miyanaga, Kayoko Kubota, Noriko Iwatani, Kenjuro Higo, Masaaki Miyata, Yoshihisa Horizoe, Satoko Ojima, Shin Kawasoe, Takuro Kubozono & Mitsuru Ohishi\nPredictors of exercise-induced pulmonary hypertension in patients with connective tissue disease\nHeart and Vessels, 34, 1509–1518, (2019)\nThis is a post-peer-review, pre-copyedit version of an article published in Heart and Vessels. \nThe final authenticated version is available online at: \nhttps://doi.org/10.1007/s00380-019-01373-6","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第514号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Springer","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:大石充】 "}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2019-04-03"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"宮永, 直","creatorNameLang":"ja"},{"creatorName":"ミヤナガ, スナオ","creatorNameLang":"ja-Kana"},{"creatorName":"Miyanaga, Sunao","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-08-18"}],"displaytype":"detail","filename":"Diss_宮永_直_ISK514_2019.pdf","filesize":[{"value":"566.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Diss_宮永_直_ISK514_2019","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/14852/files/Diss_宮永_直_ISK514_2019.pdf"},"version_id":"864090a7-8162-4946-a652-599abced2627"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-12-09"}],"displaytype":"detail","filename":"Abstract_宮永_直_4514810246_2019.pdf","filesize":[{"value":"40.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Abstract_宮永_直_4514810246_2019","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/14852/files/Abstract_宮永_直_4514810246_2019.pdf"},"version_id":"a70153ab-8562-49c2-a279-d4e4443fed8d"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-05"}],"displaytype":"detail","filename":"Result_Miyanaga_Sunao_isk_514.pdf","filesize":[{"value":"886.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Result_Miyanaga_Sunao_isk_514","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/14852/files/Result_Miyanaga_Sunao_isk_514.pdf"},"version_id":"f2d4ae3b-ab24-4588-94d3-2764f7237d65"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-05"}],"displaytype":"detail","filename":"Comments_Miyanaga_Sunao_isk_514.pdf","filesize":[{"value":"445.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_Miyanaga_Sunao_isk_514","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/14852/files/Comments_Miyanaga_Sunao_isk_514.pdf"},"version_id":"62cb25ad-0359-42f3-a4c8-53b762e09b4b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Exercise-induced pulmonary hypertension","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Connective tissue disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Echocardiography","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Right ventricular Tei index","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Predictors of Exercise-lnduced Pulmonary Hypertension in Patients with Connective Tissue Disease","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Predictors of Exercise-lnduced Pulmonary Hypertension in Patients with Connective Tissue Disease","subitem_title_language":"en"},{"subitem_title":"膠原病患者における運動誘発性肺高血圧症の予測因子の検討","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-08-05"},"publish_date":"2019-08-05","publish_status":"0","recid":"14852","relation_version_is_last":true,"title":["Predictors of Exercise-lnduced Pulmonary Hypertension in Patients with Connective Tissue Disease"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T01:50:26.090982+00:00"}