{"created":"2023-07-25T08:13:58.918619+00:00","id":14899,"links":{},"metadata":{"_buckets":{"deposit":"591c5e72-7b6c-4208-9a55-dcc6db3d04d5"},"_deposit":{"created_by":18,"id":"14899","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"14899"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00014899","sets":["57:86"]},"author_link":["134502"],"item_5_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"810","bibliographicPageStart":"802","bibliographicVolumeNumber":"20","bibliographic_titles":[{"bibliographic_title":"Gastric Cancer","bibliographic_titleLang":"en"}]}]},"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2019-08-08","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2019-08-28"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Background: E-cadherin, N-cadherin, and Snail are epithelial-mesenchymal transition (EMT)-inducible genes. Previous studies demonstrated that the expression of EMT markers in the primary tumor sites of gastric cancer correlates with tumor progression and prognosis. However, the clinical significance of the expression of these EMT markers in metastatic lymph nodes remains unclear. In the present study, we investigated the expression of these EMT markers in the primary tumor sites and metastatic lymph nodes.\nMethods: Immunohistochemistry was used to investigate the expression of E-cadherin, N-cadherin, and Snail in 89 primary tumors and 511 metastatic lymph nodes obtained from patients with gastric cancer. \nResults: The weak expression of E-cadherin in tumors and lymph nodes increased with more lymph node metastasis and in more undifferentiated tumors. The strong expression of N-cadherin in lymph nodes correlated with more lymph nodes metastasis, an advanced stage and poor prognosis. The weak expression of Snail in tumors correlated with lymphatic invasion. The strong expression of Snail in lymph nodes correlated with more lymph node metastasis and an advanced stage. The strong expression of Snail in tumors and its weak expression in lymph nodes correlated with more lymph node metastasis, an advanced stage, and poor prognosis.\nConclusions: The expression of N-cadherin in metastatic lymph nodes is useful for predicting the prognosis of patients with gastric cancer. The Snail switch, namely, the positive-to-negative conversion of the Snail status, between primary tumors and lymph node metastasis may be important for confirming EMT and mesenchymal-to-epithelial transition (MET).","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第517号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Springer","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s10120-017-0705-x","subitem_relation_type_select":"DOI"}}]},"item_5_relation_13":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"The final publication is available at link.springer.com"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s10120-017-0705-x","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Springer","subitem_rights_language":"en"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:夏越祥次】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2019-02-06"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大久保, 啓史","creatorNameLang":"ja"},{"creatorName":"オオクボ, ケイシ","creatorNameLang":"ja-Kana"},{"creatorName":"Okubo, Keishi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"134502","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-12-06"}],"displaytype":"detail","filename":"Diss_大久保_啓史_ISK517_2019.pdf","filesize":[{"value":"161.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Diss_大久保_啓史_ISK517_2019","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/14899/files/Diss_大久保_啓史_ISK517_2019.pdf"},"version_id":"2c476288-77dd-4417-9f0f-f711feda3434"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-11-26"}],"displaytype":"detail","filename":"Abstract_大久保_啓史_4513810036_2018.pdf","filesize":[{"value":"110.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Abstract_大久保_啓史_4513810036_2018","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/14899/files/Abstract_大久保_啓史_4513810036_2018.pdf"},"version_id":"95f6c652-1862-426c-b3de-64d8295422ea"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-10-08"}],"displaytype":"detail","filename":"Result_Okubo_Keishi_isk_517.pdf","filesize":[{"value":"950.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Result_Okubo_Keishi_isk_517","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/14899/files/Result_Okubo_Keishi_isk_517.pdf"},"version_id":"8397ae11-ef96-4106-a89f-0122169e8c65"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-10-08"}],"displaytype":"detail","filename":"Comments_Okubo_Keishi_isk_517.pdf","filesize":[{"value":"413.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_Okubo_Keishi_isk_517","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/14899/files/Comments_Okubo_Keishi_isk_517.pdf"},"version_id":"5f4aba23-fb04-48f4-a7af-a4eee61a0c93"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Epithelial-mesenchymal transition (EMT)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Gastric cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Metastatic lymph nodes","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Snail switch","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Clinical significance of altering epithelial-mesenchymal transition (EMT) in metastatic lymph nodes of gastric cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Clinical significance of altering epithelial-mesenchymal transition (EMT) in metastatic lymph nodes of gastric cancer","subitem_title_language":"en"},{"subitem_title":"胃癌の転移リンパ節における、EMT変化が与える臨床的意義","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-10-08"},"publish_date":"2019-10-08","publish_status":"0","recid":"14899","relation_version_is_last":true,"title":["Clinical significance of altering epithelial-mesenchymal transition (EMT) in metastatic lymph nodes of gastric cancer"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T01:50:33.764461+00:00"}