{"created":"2023-07-25T08:14:00.901384+00:00","id":14942,"links":{},"metadata":{"_buckets":{"deposit":"8166c421-e39e-4a5c-ac9d-d9ac3a2e6aef"},"_deposit":{"created_by":18,"id":"14942","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"14942"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00014942","sets":["57:86"]},"author_link":["134583"],"item_5_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"30","bibliographicVolumeNumber":"35","bibliographic_titles":[{"bibliographic_title":"Medical Oncology","bibliographic_titleLang":"en"}]}]},"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2019-11-11","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2019-11-20"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"As an antagonist of bone morphogenetic proteins (BMPs) 2, 4 and 7, gremlin1 plays a role in regulating organogenesis, tissue differentiation and angiogenesis. However, there is little information regarding gremlin1 in gastrointestinal cancer. We attempted to clarify how gremlin1 expression affects the clinical features and biological properties of gastric cancer.\nA total of 232 gastric cancer patients who received R0 gastrectomy at Kagoshima University Hospital were enrolled. Gremlin1 expression in gastric cancer was detected by immunohistochemical and western blotting methods. Correlations between clinicopathological parameters and gremlin1 expression were analyzed. Gremlin1 was identified in the cytoplasm and nucleus of all gastric cancer cell lines and some regions of surgical specimens of gastric cancer. One hundred and seventeen of the 232 patients (50.4%) were classified as gremlin1-positive based on gremlin 1 expression. Gremlin1 positivity was correlated with shallower tumor depth, smaller tumor size, less nodal involvement and vessel invasion (p<0.05). The 5-year survival rate of the gremlin1-positive group was 81%, which was significantly higher than the gremlin1-negative group (p<0.01). Multivariate analysis revealed that gremlin1 was not selected as an independent prognostic marker. Gremlin1 expression in gastric cancer may be a useful prognostic marker that is involved with the BMP signaling pathway. Furthermore, gremlin1 may have clinical use as a diagnostic and treatment tool.\n\n\nYamasaki, Y., Ishigami, S., Arigami, T. et al. \nExpression of gremlin1 in gastric cancer and its clinical significance\nMed Oncol (2018) 35: 30.\nhttps://doi.org/10.1007/s12032-017-1073-4","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第524号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s12032-017-1073-4","subitem_relation_type_select":"DOI"}}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:夏越祥次】 "}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2019-06-05"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山崎, 洋一","creatorNameLang":"ja"},{"creatorName":"ヤマサキ, ヨウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamasaki, Yoichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"134583","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-29"}],"displaytype":"detail","filename":"Diss_山﨑_洋一_ISK524_2019.pdf","filesize":[{"value":"753.9 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"Diss_山﨑_洋一_ISK524_2019","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/14942/files/Diss_山﨑_洋一_ISK524_2019.pdf"},"version_id":"0f77365a-bdd9-4dd4-8f5b-eb3e057711a7"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-29"}],"displaytype":"detail","filename":"Abstract_山﨑_洋一_4513810241_2019.pdf","filesize":[{"value":"145.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Abstract_山﨑_洋一_4513810241_2019","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/14942/files/Abstract_山﨑_洋一_4513810241_2019.pdf"},"version_id":"8658fdf1-ca62-471a-b2bf-34410a69ab33"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-11-26"}],"displaytype":"detail","filename":"Result_Yamasaki_Yoichi_isk_524.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Result_Yamasaki_Yoichi_isk_524","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/14942/files/Result_Yamasaki_Yoichi_isk_524.pdf"},"version_id":"4aef684b-1816-4e22-b4fa-f00278be2fee"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-11-26"}],"displaytype":"detail","filename":"Comments_Yamasaki_Yoichi_isk_524_2019.pdf","filesize":[{"value":"440.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_Yamasaki_Yoichi_isk_524_2019","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/14942/files/Comments_Yamasaki_Yoichi_isk_524_2019.pdf"},"version_id":"aa3f49ed-d37e-4272-9f18-a03aa63f85ee"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"gremlin1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"gastric cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"immunohistochemistry","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"survival","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Expression of gremlin1 in gastric cancer and its clinical significance","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Expression of gremlin1 in gastric cancer and its clinical significance","subitem_title_language":"en"},{"subitem_title":"胃癌におけるGremlin1の発現と、臨床病理学的意義","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-11-26"},"publish_date":"2019-11-26","publish_status":"0","recid":"14942","relation_version_is_last":true,"title":["Expression of gremlin1 in gastric cancer and its clinical significance"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T01:50:57.506537+00:00"}