{"created":"2023-07-25T08:14:00.946441+00:00","id":14943,"links":{},"metadata":{"_buckets":{"deposit":"a8c4a6f5-d25f-4aaa-a6b2-cdfd547a6454"},"_deposit":{"created_by":18,"id":"14943","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"14943"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00014943","sets":["57:86"]},"author_link":["134586"],"item_5_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019","bibliographicIssueDateType":"Issued"},"bibliographicVolumeNumber":"25","bibliographic_titles":[{"bibliographic_title":"Clinical and Applied Thrombosis/Hemostasis","bibliographic_titleLang":"en"}]}]},"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2019-11-11","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2019-11-20"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Atrial fibrillation (AF) is the most common cardiac arrhythmia in the world and has a high risk of thromboembolism. The most effective approach, catheter ablation, requires evaluation by electrocardiography. The aim of our study was to investigate novel clinical markers that predict restoration of sinus rhythm (SR) after catheter ablation. Seventy-eight consecutive patients with AF underwent catheter ablation and were separated into 2 groups: restored SR and recurrent AF. The levels of 4 blood proteins (serum or plasma) and 3 mature microRNAs (miRNAs) and their primary miRNAs (pri-miRNAs) in serum were measured before and after ablation, and the associations between each parameter were analyzed statistically. Soluble thrombomodulin (s-TM) and plasminogen activator inhibitor-1 (PAI-1) levels increased above baseline after ablation in both the restored SR (s-TM 11.55 [2.92] vs 13.75 [3.38], P < .001; PAI-1 25.74 [15.25] vs 37.79 [19.56], P < .001) and recurrent AF (s-TM 10.28 [2.78] vs 11.67 [3.37], P < .001; PAI-1 26.16 [15.70] vs 40.74 [22.55], P < .001) groups. Levels of C-reactive protein and asymmetric dimethylarginine were not significantly changed. Pri-miR-126 levels significantly decreased after ablation in the recurrent AF group, but the other miRNAs and pri-miRNAs did not. The measurement of s-TM and pri-miR-126 in blood was a useful tool to reflect the condition of AF patients with catheter ablation.\n\n\n\nNamino F. Yamakuchi M. Iriki Y. Okui H. Ichiki H. Maenosono R. Oketani N. Masamoto I. Miyata M. Horiuchi M. Hashiguchi T. Ohishi M. Maruyama I.\nDynamics of Soluble Thrombomodulin and Circulating miRNAs in Patlents with Atrial Fibrillation Undergoing Radiofrequency Catheter Ablation\nClinical and Applied Thrombosis/Hemostasis  Volume 25: 1-11\nhttps://doi.org/10.1177/1076029619851570","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第525号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"SAGE","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク ","subitem_publisher_language":"ja-Kana"}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1177/1076029619851570","subitem_relation_type_select":"DOI"}}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:橋口照人】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2019-07-03"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"波野, 史典","creatorNameLang":"ja"},{"creatorName":"ナミノ, フミノリ","creatorNameLang":"ja-Kana"},{"creatorName":"Namino, Fuminori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"134586","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-03"}],"displaytype":"detail","filename":"Diss_波野_史典_ISK525_2019.pdf","filesize":[{"value":"588.5 kB"}],"format":"application/pdf","licensetype":"license_9","mimetype":"application/pdf","url":{"label":"Diss_波野_史典_ISK525_2019","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/14943/files/Diss_波野_史典_ISK525_2019.pdf"},"version_id":"d9578ca6-2fc5-4652-a6ff-6df3cb6cc036"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-03"}],"displaytype":"detail","filename":"Abstract_波野_史典_4514810193_2019.pdf","filesize":[{"value":"172.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Abstract_波野_史典_4514810193_2019","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/14943/files/Abstract_波野_史典_4514810193_2019.pdf"},"version_id":"3e7d256f-9661-4492-a19f-bff3af4140f6"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-11-26"}],"displaytype":"detail","filename":"Result_Namino_Fuminori_isk_525_2019.pdf","filesize":[{"value":"963.3 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fibrillation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"catheter ablation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"soluble thrombomodulin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"plasminogen activator inhibitor-1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"miRNA","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"primary miRNA","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Dynamics of Soluble Thrombomodulin and Circulating miRNAs in Patlents with Atrial Fibrillation Undergoing Radiofrequency Catheter Ablation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Dynamics of Soluble Thrombomodulin and Circulating miRNAs in Patlents with Atrial Fibrillation Undergoing Radiofrequency Catheter Ablation","subitem_title_language":"en"},{"subitem_title":"高周波カテーテルアブレーション治療を施行した心房細動患者における可溶性トロンポモジュリンと循環miRNAの動態","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-11-26"},"publish_date":"2019-11-26","publish_status":"0","recid":"14943","relation_version_is_last":true,"title":["Dynamics of Soluble Thrombomodulin and Circulating miRNAs in Patlents with Atrial Fibrillation Undergoing Radiofrequency Catheter Ablation"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T01:51:02.323563+00:00"}