{"created":"2023-07-25T08:14:01.034320+00:00","id":14945,"links":{},"metadata":{"_buckets":{"deposit":"bae7e43b-b49a-452d-b5a1-df2ef10579bf"},"_deposit":{"created_by":18,"id":"14945","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"14945"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00014945","sets":["57:86"]},"author_link":["134592"],"item_5_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-3","bibliographicPageEnd":"34","bibliographicPageStart":"23","bibliographicVolumeNumber":"71","bibliographic_titles":[{"bibliographic_title":"鹿児島大学医学雑誌","bibliographic_titleLang":"ja"}]}]},"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2019-11-11","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2019-11-20"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Aim: The purpose of the present study was to investigate the influences of estrogen-dependent diseases, premature oophorectomy and anti-cancer chemotherapy on skin age in Japanese women.\nMaterials and methods: A total of 68 Japanese women were recruited between July 2016 and May 2018 at the Department of Obstetrics and Gynecology, Kagoshima University Hospital. This study included three subjects. Subject 1: A total of 57 premenopausal women were divided into two groups: those with estrogen-dependent diseases (n=19) and estrogen-independent diseases (n=38). Subject 2: A total of 26 premenopausal women were divided into two groups: those with premature oophorectomy (n=15) and ovarian preservation (n=11) during gynecological surgery. Subject 3: A total of 11 postmenopausal women who had received oophorectomy during their cancer operations were divided into two groups: those with postoperative anti-cancer chemotherapy (n=6) and those without chemotherapy (control, n=5). Facial skin parameters including skin age, relative skin age (i.e., skin age minus chronological age) and skin health conditions were assessed using a bioelectrical impedance analysis device.\nResults: 1) Relative skin age was significantly younger in women with estrogen-dependent diseases than in those with estrogenindependent diseases (-1.0 ± 1.4 vs. 2.5 ± 0.6 years, respectively, p<0.01). 2) Longitudinal changes in relative skin age at 6 months postoperatively in the oophorectomy group had progressed significantly compared with the ovarian preservation group (3.5 ± 1.4 vs. - 0.2 ± 0.8 years, respectively, p<0.05). 3) Longitudinal changes in relative skin age at 12 months after chemotherapy in postmenopausal women who received 6 courses of postoperative anti-cancer chemotherapy had progressed significantly compared with control (10.5 ± 3.3 vs. -3.8 ± 3.4 years, respectively, p<0.05). The ratio of young skin conditions was also significantly decreased after chemotherapy (from 5/6 to 1/6, respectively, p<0.05).\nConclusions: Women with estrogen-dependent diseases maintain a younger facial skin age than those with estrogen-independent diseases. However, skin aging is accelerated by premature oophorectomy and markedly accelerated by anti-cancer chemotherapy.\n\n\nLIU Shuice, ORITA Yuji, IWAMOTO Ichiro, SAKIHAMA Mika, TOGAMI Shinichi, OUCHI Tsutomu, KOBAYASHI Hiroaki\nInfluences of estrogen-dependent diseases, premature oophorectomy and anti-cancer chemotherapy on skin age in Japanese women\nMedical journal of Kagoshima University 71(1-3) 23-34, (2019) ","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第527号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"},{"subitem_publisher":"Kagoshima University","subitem_publisher_language":"en"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:小林裕明】 "}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2019-08-07"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"劉, 水策","creatorNameLang":"ja"},{"creatorName":"Liu, Shuice","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"134592","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-05"}],"displaytype":"detail","filename":"Diss_劉_水策_ISK527_2019.pdf","filesize":[{"value":"428.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Diss_劉_水策_ISK527_2019","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/14945/files/Diss_劉_水策_ISK527_2019.pdf"},"version_id":"f01c9f8f-84e6-4a3e-958b-2132874e99d4"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-02-03"}],"displaytype":"detail","filename":"Abstract_劉_水策_4515800164_2019.pdf","filesize":[{"value":"142.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Abstract_劉_水策_4515800164_2019","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/14945/files/Abstract_劉_水策_4515800164_2019.pdf"},"version_id":"9eb174af-d03e-4464-ba45-d29348e2d16e"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-11-26"}],"displaytype":"detail","filename":"Result_Shuice_Liu_isk_527_2019.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Result_Shuice_Liu_isk_527_2019","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/14945/files/Result_Shuice_Liu_isk_527_2019.pdf"},"version_id":"6addfa4d-2b55-4658-89da-9c8aa31d3b76"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-11-26"}],"displaytype":"detail","filename":"Comments_Shuice_Liu_isk_527.pdf","filesize":[{"value":"484.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_Shuice_Liu_isk_527","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/14945/files/Comments_Shuice_Liu_isk_527.pdf"},"version_id":"1c771d70-fb1d-42f8-a460-3bb12f88506d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"anti-cancer chemotherapy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"estrogen-dependent diseases","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"premature oophorectomy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"skin age","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"skin health conditions","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Influences of estrogen-dependent diseases, premature oophorectomy and anti-cancer chemotherapy on skin age in Japanese women","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Influences of estrogen-dependent diseases, premature oophorectomy and anti-cancer chemotherapy on skin age in Japanese women","subitem_title_language":"en"},{"subitem_title":"エストロゲン依存性疾患、外科的去勢および抗がん剤の肌年齢に及ぼす影響(日本人女性での検討)","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-11-26"},"publish_date":"2019-11-26","publish_status":"0","recid":"14945","relation_version_is_last":true,"title":["Influences of estrogen-dependent diseases, premature oophorectomy and anti-cancer chemotherapy on skin age in Japanese women"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T01:51:09.370053+00:00"}