{"created":"2023-07-25T08:14:03.222010+00:00","id":14995,"links":{},"metadata":{"_buckets":{"deposit":"f19dee02-af6d-4e08-b413-f72bc666d2bb"},"_deposit":{"created_by":18,"id":"14995","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"14995"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00014995","sets":["57:86"]},"author_link":["134825"],"item_5_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"18","bibliographicPageStart":"11","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"Diabetology International","bibliographic_titleLang":"en"}]}]},"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2020-01-14","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2020-01-28"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Introduction: Several studies have recently pointed out the role of many inflammatory mediators in the progression of diabetes complications. We had previously demonstrated that mRNA expression of platelet activating factor receptor (PAFR) in peripheral blood mononuclear cells (PBMCs) was associated with urinary albumin to creatinine ratio (ACR) and forearm flow-mediated dilatation in patients with type 2 diabetes. In an attempt to elucidate this association, patients were followed up for 1 year.\nMaterials and Methods: We recruited 95 patients from the hospital outpatient clinic, among whom 86 were followed up for 1 year (normoalbuminuria: 40 patients, microalbuminuria: 25 patients, macroalbuminuria: 21 patients). We then measured their baseline and 12 month characteristics and collected blood samples to extract PBMCs and measure gene expressions.\nResults: Despite higher mRNA expression of PAFR in PBMCs among patients with macroalbuminuria, the rise in its value was not associated with biomarkers of nephropathy, while baseline values were not associated with progression of nephropathy. Moreover, changes in mRNA expression of PAFR were correlated with changes in ACR in all patients (r = 0.225, p = 0.037) and estimated glomerular filtration rate in patients with macroalbuminuria (r = −0.438, p = 0.047) during the follow-up period.\nConclusion: Our findings indicate that even though no causal relationship exists between diabetic nephropathy and elevated expression of PAFR in PBMCs, their close association; signifies the presence of another common mechanism that could induce both events. Given these findings, the PAF/PAFR interaction could clarify corresponding mechanisms involved in diabetic complications.\n\n\nSahar Ghavidel Darestani, Mihoko Kurano, Atsushi Shinnakasu, Kiyoaki Yamamoto, Yukari Dochi, Kayo Uemura, Yuko Ikeda, Aiko Arimura, Hiroshi Arimura, Akira Kikuchi, Hiroshi Hashiguchi, Takahisa Deguchi, Yoshihiko Nishio\nAssociation between changes in the mRNA expression of platelet activating factor receptor in peripheral blood mononuclear cells and progression of diabetic nephropathy\nDiabetology International, 11, 11–18(2020)\nThis is a post-peer-review, pre-copyedit version of an article published in Diabetology International. \nThe final authenticated version is available online at: \nhttps://doi.org/10.1007/s13340-019-00394-w","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第534号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Springer","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:西尾善彦】 "}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2019-07-03"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ghavidel Darestani, Sahar","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"134825","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-04"}],"displaytype":"detail","filename":"Diss_Sahar Ghavidel_Darestani_ISK534_2019.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Diss_Sahar Ghavidel_Darestani_ISK534_2019","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/14995/files/Diss_Sahar Ghavidel_Darestani_ISK534_2019.pdf"},"version_id":"5ca9e8ef-6933-418c-a58a-bfa9d2dc9a1d"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-03"}],"displaytype":"detail","filename":"Abstract_Sahar Ghavidel_Darestani_4513800165_2019.pdf","filesize":[{"value":"97.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Abstract_Sahar Ghavidel_Darestani_4513800165_2019","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/14995/files/Abstract_Sahar Ghavidel_Darestani_4513800165_2019.pdf"},"version_id":"0b2ca405-71f2-4d36-8e28-78362e1336fd"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-13"}],"displaytype":"detail","filename":"Result_Sahar_Ghavidel_Darestani_isk_534.pdf","filesize":[{"value":"537.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Result_Sahar_Ghavidel_Darestani_isk_534","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/14995/files/Result_Sahar_Ghavidel_Darestani_isk_534.pdf"},"version_id":"73f921e9-8a63-4c53-8d08-f9d8ed92856b"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-13"}],"displaytype":"detail","filename":"Comments_Sahar_Ghavidel_Darestani_isk_534.pdf","filesize":[{"value":"229.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_Sahar_Ghavidel_Darestani_isk_534","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/14995/files/Comments_Sahar_Ghavidel_Darestani_isk_534.pdf"},"version_id":"e730e97a-ef7c-4c4d-976a-5f83332c64bd"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Association between changes in the mRNA expression of platelet-activating factor receptor in peripheral blood mononuclear cells and progression of diabetic nephropathy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Association between changes in the mRNA expression of platelet-activating factor receptor in peripheral blood mononuclear cells and progression of diabetic nephropathy","subitem_title_language":"en"},{"subitem_title":"末梢単核白血球の血小板活性化因子受容体(PAFR)遺伝子発現変化と糖尿病性腎症の進展との関連","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-03-13"},"publish_date":"2020-03-13","publish_status":"0","recid":"14995","relation_version_is_last":true,"title":["Association between changes in the mRNA expression of platelet-activating factor receptor in peripheral blood mononuclear cells and progression of diabetic nephropathy"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T01:51:29.768262+00:00"}