{"created":"2023-07-25T08:14:03.266582+00:00","id":14996,"links":{},"metadata":{"_buckets":{"deposit":"e2eca8b9-e318-4de3-8a66-657531ae02f2"},"_deposit":{"created_by":18,"id":"14996","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"14996"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00014996","sets":["57:86"]},"author_link":["134826"],"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2020-01-14","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2020-01-28"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Background: The development of treatment strategies to protect against ischemia-reperfusion injury (IRI) to livers is important not only for liver surgeries but also in regard to increasing the utilization of livers from marginal donors. In this study, we examined whether inhalational carbon monoxide (CO) therapy reduced IRI after a 45-minute (min) warm ischemia (WI) in a miniature swine model.\nMaterials and methods: Six CLAWN miniature swine underwent a 45-min hepatic WI induced by clamping the portal vein and proper hepatic artery. Three animals were subjected to control conditions while the remaining three were treated with CO inhalation for a total of 345-min, including 120-min after reperfusion to maintain a concentration of CO-Hb under 15% (CO-treated group). IRI of the livers was evaluated by liver function tests, serum pro-inflammatory cytokines and liver biopsies.\nResults: All controls had statistically significant increased levels of liver enzymes compared to the CO-treated group (p<0.05). In controls, liver biopsies at 2 hours after reperfusion showed marked histological changes including diffuse hemorrhage, congestion, necrosis, vacuolization and neutrophil infiltration with apoptosis. In contrast, the CO-treated group showed less obvious or only minimal histological changes. Furthermore, increases in HMGB1, TNF-α and IL-6 in sera that were induced by IRI in controls were markedly inhibited by the CO-treatment.\nConclusion: We demonstrated that low-dose CO inhalation reduces hepatic warm IRI, potentially through downregulation of pro-inflammatory mediators and activation of anti-apoptotic pathways. To our knowledge, this is the first report demonstrating CO-inhalation attenuated hepatic IRI following WI in a large animal model.\n\nTakahiro Murokawa, Hisashi Sahara, Mitsuhiro Sekijima, Thomas Pomposelli, Takehiro Iwanaga, Yurika Ichinari, Akira Shimizu & Kazuhiko Yamada \nThe Protective Effects of Carbon Monoxide Against Hepatic Warm Ischemia–Reperfusion Injury in MHC-Inbred Miniature Swine\nJournal of Gastrointestinal Surgery 24, 974–982 (2020)\nhttps://doi.org/10.1007/s11605-019-04283-0","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第535号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"springer","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:佐藤正宏】 "}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2019-10-02"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"室川, 剛廣","creatorNameLang":"ja"},{"creatorName":"ムロカワ, タカヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Murokawa, Takahiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"134826","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-01"}],"displaytype":"detail","filename":"Diss_室川_剛廣_ISK535_2019.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Diss_室川_剛廣_ISK535_2019","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/14996/files/Diss_室川_剛廣_ISK535_2019.pdf"},"version_id":"7683462f-dc81-42bb-8873-74aa1f41d734"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-03"}],"displaytype":"detail","filename":"Abstract_室川_剛廣_4515810170_2019.pdf","filesize":[{"value":"169.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Abstract_室川_剛廣_4515810170_2019","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/14996/files/Abstract_室川_剛廣_4515810170_2019.pdf"},"version_id":"ffaefe01-0054-40cc-bcda-18055b8e6074"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-13"}],"displaytype":"detail","filename":"Result_Murokawa_Takahiro_isk_535.pdf","filesize":[{"value":"522.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Result_Murokawa_Takahiro_isk_535","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/14996/files/Result_Murokawa_Takahiro_isk_535.pdf"},"version_id":"ba1952db-2e72-4f33-82fc-df38d22c945a"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-13"}],"displaytype":"detail","filename":"Comments_Murokawa_Takahiro_isk_535.pdf","filesize":[{"value":"245.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_Murokawa_Takahiro_isk_535","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/14996/files/Comments_Murokawa_Takahiro_isk_535.pdf"},"version_id":"fef3fdc7-603c-4307-8f03-e034aaf70d66"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Carbon monoxide","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Ischemia-reperfusion injury","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Liver","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Large animal model","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Proinflammatory cytokines","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"HMGB1","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"The Protective Effects of Carbon Monoxide Against Hepatic Warm Ischemia-Reperfusion Injury in MHC-lnbred Miniature Swine","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The Protective Effects of Carbon Monoxide Against Hepatic Warm Ischemia-Reperfusion Injury in MHC-lnbred Miniature Swine","subitem_title_language":"en"},{"subitem_title":"MHC確立クラウン系ミニブタ肝臓温虚血再灌流障害に対する一酸化炭素の保護効果","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-03-13"},"publish_date":"2020-03-13","publish_status":"0","recid":"14996","relation_version_is_last":true,"title":["The Protective Effects of Carbon Monoxide Against Hepatic Warm Ischemia-Reperfusion Injury in MHC-lnbred Miniature Swine"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T01:51:32.878340+00:00"}