{"created":"2023-07-25T08:14:03.356745+00:00","id":14998,"links":{},"metadata":{"_buckets":{"deposit":"3baa017d-a2ed-40c6-849d-30e9953bc458"},"_deposit":{"created_by":18,"id":"14998","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"14998"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00014998","sets":["57:86"]},"author_link":["134832"],"item_5_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"1496","bibliographicPageStart":"1487","bibliographicVolumeNumber":"43","bibliographic_titles":[{"bibliographic_title":"International Journal of Molecular Medicine","bibliographic_titleLang":"en"}]}]},"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2020-02-07","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2020-02-17"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Excessive fructose intake is a risk factor for gut symptoms in patients with inflammatory bowel disease, however, its effect on the intestinal tract has not been evaluated previously. The present study investigated the impact of a high‑fructose diet (HFD) on intestinal barrier function in mice with experimental colitis. C57/BL6 mice were provided with either a HFD or control diet and either plain drinking water or water containing 1% dextran sulfate sodium (DSS) for 2 weeks. The disease activity index (DAI), pathological scores and expression of inflammatory cytokines were compared among the groups, and the proportions of fecal bacteria in the colon were analyzed. The body weight and colon length were significantly decreased, and the DAI and pathological scores were significantly increased in the DSS/HFD‑treated mice compared with the non‑D SS‑treated and control diet mice. Regarding the expression of inflammatory cytokines, the levels of interleukin (IL)‑6, IL‑1β and tumor necrosis factor‑α were significantly increased, and the expression of the tight junction protein occludin was significantly decreased in the DSS/HFD‑ treated mice. The total bacterial count was increased in the HFD mice. Taken together, these results indicate that an HFD resulted in the deterioration of intestinal barrier function and increased susceptibility to DSS‑induced colitis.\n\nKatsuto Kawabata, Shuji Kanmura, Yuko Morinaga, Akihito Tanaka, Tomoaki Makino, Toshihiro Fujita, Shiho Arima, Fumisato Sasaki, Yuichirou Nasu, Shiroh Tanoue, Shinichi Hashimoto, Akio Ido\nA high‑fructose diet induces epithelial barrier dysfunction and exacerbates the severity of dextran sulfate sodium‑induced colitis\nInternational Journal of Molecular Medicine, 43, 1487-1496, 2019\nDOI:https://doi.org/10.3892/ijmm.2018.4040","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第537号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Spandidos Publications","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3892/ijmm.2018.4040","subitem_relation_type_select":"DOI"}}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:上村修司】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2019-09-04"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"川畑, 活人","creatorNameLang":"ja"},{"creatorName":"カワバタ, カツト","creatorNameLang":"ja-Kana"},{"creatorName":"Kawabata, Katsuto","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-03"}],"displaytype":"detail","filename":"Diss_川畑_活人_ISK537_ 2019.pdf","filesize":[{"value":"868.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Diss_川畑_活人_ISK537_ 2019","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/14998/files/Diss_川畑_活人_ISK537_ 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MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Result_Kawabata_Katsuto_isk_537","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/14998/files/Result_Kawabata_Katsuto_isk_537.pdf"},"version_id":"d50e5ed3-a85e-4b59-bfa2-6a6c14328370"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-16"}],"displaytype":"detail","filename":"Comments_Kawabata_Katsuto_isk_537.pdf","filesize":[{"value":"401.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_Kawabata_Katsuto_isk_537","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/14998/files/Comments_Kawabata_Katsuto_isk_537.pdf"},"version_id":"20842b02-1299-4914-bf9a-3b8c4f7e663d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"inflammatory bowel disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"fructose, paracellular permeability","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tight junction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"microbiota","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"A high-fructose diet induces epithelial barrier dysfunction and exacerbates the severity of dextran sulfate sodium-induced colitis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A high-fructose diet induces epithelial barrier dysfunction and exacerbates the severity of dextran sulfate sodium-induced colitis","subitem_title_language":"en"},{"subitem_title":"高フルクトース食は腸管上皮のバリア機能を障害し、DSS腸炎を悪化させる","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-03-16"},"publish_date":"2020-03-16","publish_status":"0","recid":"14998","relation_version_is_last":true,"title":["A high-fructose diet induces epithelial barrier dysfunction and exacerbates the severity of dextran sulfate sodium-induced colitis"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T01:56:31.366068+00:00"}