{"created":"2023-07-25T08:14:11.549348+00:00","id":15170,"links":{},"metadata":{"_buckets":{"deposit":"4715582c-2437-4d13-b04e-0bed4094d9da"},"_deposit":{"created_by":18,"id":"15170","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"15170"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00015170","sets":["57:86"]},"author_link":["135804"],"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2020-03-06","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2020-03-12"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Immune checkpoint inhibitor therapy has been clinically introduced for several malignancies, and its effectiveness has been confirmed by clinical trials. In particular, programmed cell death protein 1 (PD-1) and programmed death-ligand 1 (PD-L1) are widely known as important immune checkpoint molecules associated with the mechanisms of immune escape by malignant tumor cells. In addition, liquid biopsy of blood specimens has the clinical benefit of providing a simple, repeatable sampling tool. Non-invasive liquid biopsy has recently been spotlighted as a promising approach to predicting tumor progression and prognosis. This study assessed the clinical significance of PD-L1 mRNA expression in blood specimens obtained from patients with gastric cancer. Peripheral blood specimens were collected before treatment from 124 patients with gastric cancer. The PD-L1 mRNA expression was evaluated by quantitative RT-PCR. Programmed death-ligand 1 mRNA expression was significantly higher in patients with advanced gastric cancer than in patients with early gastric cancer (P = .002). Moreover, PD-L1 expression correlated significantly with depth of tumor invasion, distant metastasis, and stage (P = .001, P < .001, and P < .001, respectively). Patients with high PD-L1 expression showed significantly poorer prognosis than those with low PD-L1 expression (P < .0001). Multivariate analysis indicated PD-L1 expression as an independent prognostic factor. Expression of PD-L1 in peripheral blood may offer an immunological predictor of tumor progression and disease outcome in patients with gastric cancer.\n\nMasahiko Amatatsu, Takaaki Arigami, Yoshikazu Uenosono, Shigehiro Yanagita, Yasuto Uchikado, Yuko Kijima, Hiroshi Kurahara, Yoshiaki Kita, Shinichiro Mori, Ken Sasaki, Itaru Omoto, Kosei Maemura, Sumiya Ishigami, Shoji Natsugoe\nProgrammed death-ligand 1 is a promising blood marker for predicting tumor progression and prognosis in patients with gastric cancer\nCancer Science 2018 109(3) 814-820\nhttps://doi.org/10.1111/cas.13508","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第540号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Wiley","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学 ","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:夏越祥次】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2019-07-03"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"天辰, 仁彦","creatorNameLang":"ja"},{"creatorName":"アマタツ, マサヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Amatatsu, Masahiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"135804","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-01"}],"displaytype":"detail","filename":"Diss_天辰_仁彦_ISK540_2019.pdf","filesize":[{"value":"505.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Diss_天辰_仁彦_ISK540_2019","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/15170/files/Diss_天辰_仁彦_ISK540_2019.pdf"},"version_id":"9b14c3a7-435a-4f26-a969-64b17e361391"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-01"}],"displaytype":"detail","filename":"Abstract_天辰_仁彦_4514810012_2019.pdf","filesize":[{"value":"177.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Abstract_天辰_仁彦_4514810012_2019","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/15170/files/Abstract_天辰_仁彦_4514810012_2019.pdf"},"version_id":"a996bf4f-0a23-44ce-a8b7-dedc2e4008b1"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-05-21"}],"displaytype":"detail","filename":"Result_Amatatsu_Masahiko_isk_540.pdf","filesize":[{"value":"193.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Result_Amatatsu_Masahiko_isk_540","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/15170/files/Result_Amatatsu_Masahiko_isk_540.pdf"},"version_id":"52db0798-6830-458b-8996-2ee8139fc296"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-05-21"}],"displaytype":"detail","filename":"Comments_Amatatsu_Masahiko_isk_540.pdf","filesize":[{"value":"89.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_Amatatsu_Masahiko_isk_540","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/15170/files/Comments_Amatatsu_Masahiko_isk_540.pdf"},"version_id":"a88dd11e-3b0b-416c-9952-d9b36527a9d1"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"gastric cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"liquid biopsy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"peripheral blood","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"prognosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"programmed death-ligand 1","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Programmed death-ligand 1 is a promising blood maker for predicting tumor progression and prognosis in patients with gastric cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Programmed death-ligand 1 is a promising blood maker for predicting tumor progression and prognosis in patients with gastric cancer","subitem_title_language":"en"},{"subitem_title":"胃癌において Programmed death-ligand 1 は腫瘍悪牲度や予後の予測のための有用な血液マーカーである","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-05-21"},"publish_date":"2020-05-21","publish_status":"0","recid":"15170","relation_version_is_last":true,"title":["Programmed death-ligand 1 is a promising blood maker for predicting tumor progression and prognosis in patients with gastric cancer"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T01:56:39.296672+00:00"}