{"created":"2023-07-25T08:14:11.636984+00:00","id":15172,"links":{},"metadata":{"_buckets":{"deposit":"41ef9f38-a1c9-49df-b321-f92d71902c2c"},"_deposit":{"created_by":18,"id":"15172","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"15172"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00015172","sets":["57:86"]},"author_link":["135810"],"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2020-03-06","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2020-03-12"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"In folk medicine, it has long been believed that odorous compounds derived from plant extracts can have anxiolytic effects. Among them, linalool, one of the terpene alcohols in lavender extracts, has been reported to have the anxiolytic effects. However, the anxiolytic nature of the linalool odor itself as well as its potential action through the olfactory system has not been thoroughly examined. In this study, we examined the anxiolytic effects of linalool odor with light/dark box test and with elevated plus maze (EPM), and found that linalool odor has an anxiolytic effect without motor impairment in mice. The effect was not observed in anosmic mice, indicating that it was triggered by olfactory input evoked by linalool odor. Furthermore, the effect was antagonized by flumazenil, indicating that the linalool odor-induced anxiolytic effect was mediated by g-aminobutyric acid (GABA)ergic transmission via benzodiazepine (BDZ)-responsive GABAA receptors. These results provide information about the potential central neuronal mechanisms underlying the odor-induced anxiolytic effects and the foundation for exploring clinical application of linalool odor in anxiety treatments.\n\nHiroki Harada, Hideki Kashiwadani, Yuichi Kanmura and Tomoyuki Kuwaki\nLinalool Odor-Induced Anxiolytic Effects in Mice\nFrontiers in Behavioral Neuroscience, 2018\nhttps://doi.org/10.3389/fnbeh.2018.00241","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第542号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Frontiers Media S.A.","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:上村裕一】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2020-01-08"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"原田, 浩輝","creatorNameLang":"ja"},{"creatorName":"ハラダ, ヒロキ","creatorNameLang":"ja-Kana"},{"creatorName":"Harada, Hiroki","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-02"}],"displaytype":"detail","filename":"Diss_原田_浩輝_ISK542_2019.pdf","filesize":[{"value":"830.5 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"Diss_原田_浩輝_ISK542_2019","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/15172/files/Diss_原田_浩輝_ISK542_2019.pdf"},"version_id":"8dc7dfbf-6bf3-4490-8d15-b1bd910b98de"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-02"}],"displaytype":"detail","filename":"Abstract_原田_浩輝_4514810219_2019.pdf","filesize":[{"value":"149.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Abstract_原田_浩輝_4514810219_2019","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/15172/files/Abstract_原田_浩輝_4514810219_2019.pdf"},"version_id":"735c06f2-be7a-46ac-9035-621d8aa5c13f"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-05-21"}],"displaytype":"detail","filename":"Result_Harada_Hiroki_isk_542.pdf","filesize":[{"value":"184.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Result_Harada_Hiroki_isk_542","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/15172/files/Result_Harada_Hiroki_isk_542.pdf"},"version_id":"2fed86f0-9765-445d-9b9d-ad0745012f6d"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-05-21"}],"displaytype":"detail","filename":"Comments_Harada_Hiroki_isk_542.pdf","filesize":[{"value":"91.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_Harada_Hiroki_isk_542","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/15172/files/Comments_Harada_Hiroki_isk_542.pdf"},"version_id":"dda855ae-9a14-4b48-87c2-a985a8fc23d6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"linalool","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"odor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"anxiety","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"anxiolytic","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"benzodiazepine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"flumazenil","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Linalool Odor-lnduced Anxiolytic Effects in Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Linalool Odor-lnduced Anxiolytic Effects in Mice","subitem_title_language":"en"},{"subitem_title":"マウスにおいて、リナロール香気は抗不安効果を示す","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-05-21"},"publish_date":"2020-05-21","publish_status":"0","recid":"15172","relation_version_is_last":true,"title":["Linalool Odor-lnduced Anxiolytic Effects in Mice"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T01:56:47.891270+00:00"}