{"created":"2023-07-25T08:14:11.681296+00:00","id":15173,"links":{},"metadata":{"_buckets":{"deposit":"51dafde9-4bb8-4677-a694-d01f7b3fc1ea"},"_deposit":{"created_by":18,"id":"15173","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"15173"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00015173","sets":["57:86"]},"author_link":["135813"],"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2020-03-06","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2020-03-12"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Retention of the ability to wake from sleep in response to dangerous situations is an ideal characteristic of safe hypnotics. We studied the effects of a dual orexin receptor antagonist-22 (DORA-22) and the GABA-A receptor modulator, triazolam, on the ability to wake in response to aversive stimuli. We examined four modalities of sensory inputs, namely, auditory (ultrasonic sound), vestibular (trembling), olfactory (predator odor), and autonomic (hypoxia) stimuli. When the mice fell asleep, one of the four stimuli was applied for 30 s. In the case of auditory stimulation, latency to arousal following vehicle, DORA-22, and triazolam administration was 3.0 (2.0–3.8), 3.5 (2.0–6.5), and 161 (117–267) s (median and 25–75 percentile in the parentheses, n = 8), respectively. Latency to return to sleep after arousal was 148 (95–183), 70 (43–98), and 60 (52–69) s, respectively. Similar results were obtained for vestibular and olfactory stimulation. During the hypoxic stimulation, latencies for arousal and returning to sleep were not significantly different among the groups. The findings of this study are consistent with the distinct mechanisms of these sleep promoting therapies; GABA-A receptor activation by triazolam is thought to induce widespread central nervous system (CNS) suppression while DORA-22 more specifically targets sleep/wake pathways through orexin receptor antagonism. These data support the notion that DORA-22 preserves the ability to wake in response to aversive and consciousness-inducing sensory stimuli, regardless of modality, while remaining effective in the absence of threat. This study provides a unique and important safety evaluation of the potential for certain hypnotics.\n\nShouhei Iwakawa, Yuichi Kanmura and Tomoyuki Kuwaki\nOrexin Receptor Blockade-Induced Sleep Preserves the Ability to Wake in the Presence of Threat in Mice\nFrontiers in Behavioral Neuroscience, 2019\nhttps://doi.org/10.3389/fnbeh.2018.00327","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第543号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Frontiers Media S.A.","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学 ","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:上村裕一】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2020-01-08"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"岩川, 昌平","creatorNameLang":"ja"},{"creatorName":"イワカワ, ショウヘイ","creatorNameLang":"ja-Kana"},{"creatorName":"Iwakawa, Shohei","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"135813","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-02"}],"displaytype":"detail","filename":"Diss_岩川_昌平_ISK543_2019.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"Diss_岩川_昌平_ISK543_2019","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/15173/files/Diss_岩川_昌平_ISK543_2019.pdf"},"version_id":"b82fdf47-f67d-4e1f-9164-a744966ecdfe"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-02"}],"displaytype":"detail","filename":"Abstract_岩川_昌平_4515810231_2019.pdf","filesize":[{"value":"110.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Abstract_岩川_昌平_4515810231_2019","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/15173/files/Abstract_岩川_昌平_4515810231_2019.pdf"},"version_id":"e3f2549b-5a97-4eac-b1bb-501ec63bc663"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-05-21"}],"displaytype":"detail","filename":"Result_Iwakawa_Shohei_isk_543.pdf","filesize":[{"value":"191.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Result_Iwakawa_Shohei_isk_543","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/15173/files/Result_Iwakawa_Shohei_isk_543.pdf"},"version_id":"bb2cc091-b80d-4092-8086-fb1655e73a0b"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-05-21"}],"displaytype":"detail","filename":"Comments_Iwakawa_Shohei_isk_543.pdf","filesize":[{"value":"88.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_Iwakawa_Shohei_isk_543","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/15173/files/Comments_Iwakawa_Shohei_isk_543.pdf"},"version_id":"d10d5c99-b314-47dd-a538-0db8b8159302"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"orexin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hypocretin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hypnotics","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"dual orexin receptor antagonist","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"triazolam","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"aversive stimuli","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Orexin Receptor Blockade-Induced Sleep Preserves the Ability to Wake in the Presence of Threat in Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Orexin Receptor Blockade-Induced Sleep Preserves the Ability to Wake in the Presence of Threat in Mice","subitem_title_language":"en"},{"subitem_title":"オレキシン受容体拮抗薬で睡眠誘導されたマウスは、睡眠中においても危機的状況下では覚醒能力を保持することができる","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-05-21"},"publish_date":"2020-05-21","publish_status":"0","recid":"15173","relation_version_is_last":true,"title":["Orexin Receptor Blockade-Induced Sleep Preserves the Ability to Wake in the Presence of Threat in Mice"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T01:56:49.060191+00:00"}