{"created":"2023-07-25T08:14:11.986055+00:00","id":15180,"links":{},"metadata":{"_buckets":{"deposit":"5e360c48-c860-485a-8087-0927dfeeef7d"},"_deposit":{"created_by":29,"id":"15180","owners":[29],"pid":{"revision_id":0,"type":"depid","value":"15180"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00015180","sets":["57:86"]},"author_link":["135834"],"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2020-03-06","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2020-03-25"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学 "}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Glioblastoma multiforme (GBM), the most common primary malignant brain tumor in adults, is characterized by rapid proliferation, aggressive migration, and invasion into normal brain tissue. Formin proteins have been implicated in these processes. However, the role of formin-like 1 (FMNL1) in cancer remains unclear. We studied FMNL1 expression in glioblastoma samples using immunohistochemistry. We sought to analyze the correlation between FMNL1 expression, clinicopathologic variables, and patient survival. Migration and invasion assays were used to verify the e<br />ect of FMNL1 on glioblastoma cell lines. Microarray data were downloaded from The Cancer Genome Atlas and analyzed using gene set enrichment analysis (GSEA). FMNL1 was an independent predictor of poor prognosis in a cohort of 217 glioblastoma multiforme cases (p < 0.001). FMNL1 expression was significantly higher in the mesenchymal subtype. FMNL1 upregulation and downregulation were associated with mesenchymal and proneural markers in the GSEA, respectively. These data highlight the important role of FMNL1 in the neural-to-mesenchymal transition. Conversely, FMNL1 downregulation suppressed glioblastoma multiforme cell migration and invasion via DIAPH1 and GOLGA2, respectively. FMNL1 downregulation also suppressed actin fiber assembly, induced morphological changes, and diminished filamentous actin. FMNL1 is a promising therapeutic target and a useful biomarker for GBM progression. \n\nNayuta Higa, Yoshinari Shinsato, Muhammad Kamil, Takuro Hirano, Tomoko Takajo , Michiko Shimokawa, Kentaro Minami, Masatatsu Yamamoto, Kohichi Kawahara, Hajime Yonezawa, Hirofumi Hirano, Tatsuhiko Furukawa, Koji Yoshimoto and Kazunori Arita\nFormin-like 1 (FMNL1) Is Associated with Glioblastoma Multiforme Mesenchymal Subtype and Independently Predicts Poor Prognosis\nInternational Journal of Molecular Sciences 2019, 20, 6355\nhttps://doi.org/10.3390/ijms20246355","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第550号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI journals","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"【指導教員:吉本幸司】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2020-02-05"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"比嘉, 那優大","creatorNameLang":"ja"},{"creatorName":"ヒガ, ナユタ","creatorNameLang":"ja-Kana"},{"creatorName":"Higa, Nayuta","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"135834","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-02"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2020-03-06"}],"filename":"Diss_比嘉_那優大_ISK550_2019.pdf","filesize":[{"value":"4.8 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"Diss_比嘉_那優大_ISK550_2019","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/15180/files/Diss_比嘉_那優大_ISK550_2019.pdf"},"version_id":"e1bf94c5-392e-4945-aada-f09962625d81"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-02"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2020-03-06"}],"filename":"Abstract_比嘉_那優大_4516810183_2019.pdf","filesize":[{"value":"229.3 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"Abstract_比嘉_那優大_4516810183_2019","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/15180/files/Abstract_比嘉_那優大_4516810183_2019.pdf"},"version_id":"ea7eb9d6-8966-4d8c-b28d-76c5b20ad2b7"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-05-21"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2020-03-06"}],"filename":"Result_Higa_Nayuta_isk_550.pdf","filesize":[{"value":"224.5 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"Result_Higa_Nayuta_isk_550","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/15180/files/Result_Higa_Nayuta_isk_550.pdf"},"version_id":"5c1a2b0f-01ad-420e-9eb9-e0dd1f06fbfb"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-05-21"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2020-03-06"}],"filename":"Comments_Higa_Nayuta_isk_550.pdf","filesize":[{"value":"90.5 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"Comments_Higa_Nayuta_isk_550","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/15180/files/Comments_Higa_Nayuta_isk_550.pdf"},"version_id":"609af9e8-92e9-4ae1-a78d-887122a3d650"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"formin-like 1 (FMNL1)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"DIAPH1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"GOLGA2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"invasion","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"migration","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mesenchymal subtype","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Formin-like 1(FMNL1) Is Associated with Glioblastma Multiforme Mesenchymal Subtype and Independently Prediots Poor Prognosis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Formin-like 1(FMNL1) Is Associated with Glioblastma Multiforme Mesenchymal Subtype and Independently Prediots Poor Prognosis","subitem_title_language":"en"},{"subitem_title":"Formin-like 1(FMNL1)は膠芽腫のmesenchymal subtypeに関連し、独立した予後不良因子である","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"29","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-05-21"},"publish_date":"2020-05-21","publish_status":"0","recid":"15180","relation_version_is_last":true,"title":["Formin-like 1(FMNL1) Is Associated with Glioblastma Multiforme Mesenchymal Subtype and Independently Prediots Poor Prognosis"],"weko_creator_id":"29","weko_shared_id":-1},"updated":"2025-08-28T05:34:41.885877+00:00"}