{"created":"2023-07-25T08:14:12.205781+00:00","id":15185,"links":{},"metadata":{"_buckets":{"deposit":"f547f95b-0fd3-4acf-bf79-2f9d553977d8"},"_deposit":{"created_by":18,"id":"15185","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"15185"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00015185","sets":["57:86"]},"author_link":["135845"],"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2020-03-06","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2020-03-25"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Pituitary adenylate cyclase-activating polypeptide (PACAP) is abundantly expressed in the hypothalamus and contributes to hypothalamic functions, including appetite regulation. Although food intake is suggested to be decreased in PACAP (−/−) mice, the detailed mechanisms are still being discussed. We sought to investigate this link. The food consumption at 8 h after refeeding in the (−/−) mice who had fasted for 2 days was significantly lower than in the PACAP (+/+) mice. The nocturnal and daily food intake of (−/−) mice was significantly lower than those of (+/+) mice, but the diurnal food intake showed a tendency to increase. mRNA expression levels of agouti-related peptide (AgRP) were decreased, but those of proopiomelanocortin (POMC) were increased in the hypothalamus of (−/−) mice 4 h after refeeding. Furthermore, intracerebroventricular administration of a PACAP receptor antagonist, PACAP6–38 (1 nmol/4 μL/mouse), decreased food intake and body weight 1, 2, and 4 h after refeeding, as well as expression levels of AgRP at 4 h after refeeding in (+/+) mice. The selective overexpression of PACAP by the infection of an adeno-associated virus in the ventromedial hypothalamus (VMH) resulted in an increase in food intake and AgRP expression in the nocturnal period in addition to the increased food intake at 8 h after refeeding. These results suggest that food intake behavior in mice is triggered by the increase in PACAP expression in the VMH via modulation of AgRP expression in the hypothalamus, pointing to PACAP inhibition as a potential strategy for the development of anti-obesity drugs.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第555号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"springer","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:宮田篤郎】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2020-02-05"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nguyen, Thanh Trung","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-05"}],"displaytype":"detail","filename":"Abstract_NGUYEN THANH TRUNG_4516810263_2019.pdf","filesize":[{"value":"178.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Abstract_NGUYEN THANH TRUNG_4516810263_2019","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/15185/files/Abstract_NGUYEN THANH TRUNG_4516810263_2019.pdf"},"version_id":"527d0b46-a1ae-42b8-b962-0c5043791aea"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-05-21"}],"displaytype":"detail","filename":"Result_Nguyen_Thanh_Trung_isk_555.pdf","filesize":[{"value":"173.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Result_Nguyen_Thanh_Trung_isk_555","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/15185/files/Result_Nguyen_Thanh_Trung_isk_555.pdf"},"version_id":"927a2d29-d510-452e-9ab3-2b10d3b56260"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-05-21"}],"displaytype":"detail","filename":"Comments_Nguyen_Thanh_Trung_isk_555.pdf","filesize":[{"value":"95.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_Nguyen_Thanh_Trung_isk_555","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/15185/files/Comments_Nguyen_Thanh_Trung_isk_555.pdf"},"version_id":"87435ca9-2032-4e6d-bc52-3f934081f968"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Pituitary adenylate cyclase-activating polypeptide","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"72 Ventromedial hypothalamus","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Appetite","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Agouti-related peptide","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Food intake","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"Pituitary Adenylate Cyclase-Activating Polypeptide in the Ventromedial Hypothalamus is Responsible for Food-Intake Behavior by Modulating the Expression of Agouti-Related Peptide in Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Pituitary Adenylate Cyclase-Activating Polypeptide in the Ventromedial Hypothalamus is Responsible for Food-Intake Behavior by Modulating the Expression of Agouti-Related Peptide in Mice","subitem_title_language":"en"},{"subitem_title":"視床下部腹内側部の下垂体アデニル酸シクラーゼ活性化ポリペプチドはアグーチベプチドの発現を調節することによりマウスの摂食行動に関与する","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-05-21"},"publish_date":"2020-05-21","publish_status":"0","recid":"15185","relation_version_is_last":true,"title":["Pituitary Adenylate Cyclase-Activating Polypeptide in the Ventromedial Hypothalamus is Responsible for Food-Intake Behavior by Modulating the Expression of Agouti-Related Peptide in Mice"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T01:57:27.437269+00:00"}