{"created":"2023-07-25T08:14:14.546578+00:00","id":15238,"links":{},"metadata":{"_buckets":{"deposit":"33bc9ee3-f0b4-48d8-8e6c-2c85aeb244ee"},"_deposit":{"created_by":18,"id":"15238","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"15238"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00015238","sets":["57:86"]},"author_link":["136136"],"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2020-04-02","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2020-04-20"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Nonalcoholic fatty liver disease (NAFLD) is recognized as a hepatic manifestation of metabolic syndrome because of the association with visceral obesity. However, the association between NAFLD and subcutaneous fat accumulation remains unclear.\nThe study population included 3197 participants in regular health checkups, who were both hepatitis B virus surface antigen and hepatitisCvirus antibody-negative, andconsumed<20g of alcohol per day. Theyweredivided according to 4 quantiles of subcutaneous fat area (SFA) and visceral fat area (VFA) on computed tomography. Fatty liver was diagnosed using ultrasonography (FL-US).\nThe prevalence of FL-US increased across the SFA categories, even after adjusting for the VFA, in both men (P<.001) and women (P<.001). This significant association between FL-US and the SFA was already detected from the second SFA quantile. It is noteworthy that the mean body mass index (BMI) of the subjects in the second quantile was 23.7kg/m2 in men and 22.6kg/m2 in women. Independent positive associations were observed between alanine aminotransferase elevation, and both the SFA and VFA in men, while gamma glutamyl transpeptidase elevation was independently associated with the VFA, but not the SFA, in both men and women. Similarly, the components of metabolic syndrome were independently associated with the VFA, but were less strongly associated (or not associated at all) with the SFA.\nThis cross-sectional study suggests that NAFLD is independently associated with both visceral and subcutaneous adiposity ab initio, which is a characteristic that distinguishes NAFLD from other components of metabolic syndrome.\n\nTakeshi Kure, Seiichi Mawatari, Yasushi Imamura, Kotaro Kumagai,Yasunari Hiramine, Hironori Miyahara, Shuji Kanmura, Akihiro Moriuchi, Hirofumi Uto, Masahisa Horiuchi\nNonalcoholic fatty liver disease is associated with both subcutaneous and visceral adiposity\nMedicine, 2019 98(46) p.e17879\nhttp://dx.doi.org/10.1097/MD.0000000000017879","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第560号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Wolters Kluwer Health","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:井戸章雄】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2020-01-08"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"呉, 建","creatorNameLang":"ja"},{"creatorName":"クレ, タケシ","creatorNameLang":"ja-Kana"},{"creatorName":"Kure, Takeshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"136136","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-30"}],"displaytype":"detail","filename":"Diss_呉_建_ISK560_2020.pdf","filesize":[{"value":"231.8 kB"}],"format":"application/pdf","licensetype":"license_9","mimetype":"application/pdf","url":{"label":"Diss_呉_建_ISK560_2020","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/15238/files/Diss_呉_建_ISK560_2020.pdf"},"version_id":"a20c9924-aa86-427c-b0fd-ab83852320b3"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-30"}],"displaytype":"detail","filename":"Abstract_呉_建_4508800244_2019.pdf","filesize":[{"value":"123.3 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kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_Kure_Takeshi_isk_560","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/15238/files/Comments_Kure_Takeshi_isk_560.pdf"},"version_id":"cf699464-90a6-46f1-aaa0-8fdf42859e1e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"metabolic syndrome","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"nonalcoholic fatty liver disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"subcutaneous obesity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"visceral obesity","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Nonalcoholic fatty liver disease is associated with both subcutaneous and visceral adiposity : A cross-sectional study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Nonalcoholic fatty liver disease is associated with both subcutaneous and visceral adiposity : A cross-sectional study","subitem_title_language":"en"},{"subitem_title":"非アルコール性脂肪性肝疾患は皮下および内臓肥満と関連する : 横断研究","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-07-08"},"publish_date":"2020-07-08","publish_status":"0","recid":"15238","relation_version_is_last":true,"title":["Nonalcoholic fatty liver disease is associated with both subcutaneous and visceral adiposity : A cross-sectional study"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T01:57:42.193303+00:00"}