@phdthesis{oai:ir.kagoshima-u.ac.jp:00015243,
 author = {平田, 宗嗣 and Hirata, Munetsugu},
 month = {2021-05-06, 2021-05-06, 2020-08-19, 2020-08-19},
 note = {博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨, Background: Human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus that causes adult T-cell leukemia/lymphoma (ATL), an aggressive form of T-cell malignancy. The relationship between HTLV-1 infection and cancer progression is controversial. HTLV-1 encodes oncogenic protein TAX1 and it is hypothesized that HTLV-1 infection is associated with breast cancer progression. In this study, we evaluated the relationship between HTLV-1 infection and clinicopathological factors in breast cancer patients. Methods: We retrospectively analyzed 610 patients with primary breast cancer who underwent surgical treatment without preoperative chemotherapy at Kagoshima University Hospital between January 2001 and January 2015. Results: When patients with and without HTLV-1 infection were compared, no differences in clinicopathological factors were observed, except for age. Disease-free survival and overall survival rates did not differ between groups. Conclusions: HTLV-1–positive patients were significantly older than HTLV-1–negative patients. It was supposed to be due to the fact that the HTLV-1 infection rate is decreasing. Any effect of HTLV-1 infection on breast cancer progression appears to be negligibly small.

Munetsugu Hirata, Yoshiaki Shinden, Ayako Nagata, Yuki Nomoto, Hazuki Saho, Akihiro Nakajo, Takaaki Arigami, Hiroshi Kurahara, Kosei Maemura, Shoji Natsugoe, Yuko Kijima
Clinical Features of Breast Cancer Patients with Human T-Cell Lymphotropic Virus Type-1 Infection
Asian Pacific Journal of Cancer Prevention, 20(6), 2019 P.1909-1912
DOI:10.31557/APJCP.2019.20.6.1909},
 school = {鹿児島大学},
 title = {Clinical Features of Breast Cancer Patients with Human T-Cell Lymphotropic Virus Type-1 Infection},
 year = {},
 yomi = {ヒラタ, ムネツグ}
}