{"created":"2023-07-25T08:14:14.940280+00:00","id":15247,"links":{},"metadata":{"_buckets":{"deposit":"964bc8a9-b73b-46a0-a0c1-bd9c26ef04cd"},"_deposit":{"created_by":18,"id":"15247","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"15247"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00015247","sets":["57:86"]},"author_link":["136193"],"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2020-07-03","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2020-07-15"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Purpose: Recent developments in molecular-targeted therapies have improved the clinical outcome of cancer patients; however, the issue of adverse effects due to treatments has often gone unconsidered. We herein report the results of a clinical trial of dual genomic analyses for healthy longevity in a postoperative cancer patient.\nMethods: We performed dual genomic analyses for a representative 79-year-old rectal cancer patient who relapsed with liver metastasis. First, we determined single-nucleotide polymorphisms according to the constitution and disease risk in the genomic DNA from the patient’s saliva by referring to the data of 10,000 Japanese patients obtained from Yahoo Japan Corporation. Second, we conducted whole-exome sequencing to detect druggable mutations in the primary tumour.\nResults: Forty of 59 determinable characters related to the constitution were consistent with the clinical phenotype. Several diseases classified as ‘high risk’ diseases actually occurred during the patient’s clinical course. Of the 129 significant mutations, we identified somatic mutations in BRAF, PIK3CA, and SMAD4 as targets.\nConclusion: The dual genomic examination will improve the follow-up observation system to support primary care doctors in the social community for taking care of postoperative cancer patients.\n\nNaoki Hayashi, Yosuke Kuroda, Tomoko Saito, Yusuke Tsuruda, Atsushi Niida, Hajime Otsu, Hidetoshi Eguchi, Takaaki Masuda, Yutaka Suzuki, Shoji Natsugoe & Koshi Mimori\nA clinical trial of somatic and germline analyses for healthy longevity in a postoperative cancer patient\nSurgery Today, 49, p.738–747 (2019)\nhttps://doi.org/10.1007/s00595-019-01789-7\nThis is a post-peer-review, pre-copyedit version of an article published in Surgery Today. \nThe final authenticated version is available online at: \nhttps://doi.org/10.1007/s00595-019-01789-7","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第567号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"springer","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:大塚隆生】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2020-05-07"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"林, 直樹","creatorNameLang":"ja"},{"creatorName":"ハヤシ, ナオキ","creatorNameLang":"ja-Kana"},{"creatorName":"Hayashi, Naoki","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-05-07"}],"displaytype":"detail","filename":"Diss_林_直樹_ISK567_2020.pdf","filesize":[{"value":"743.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Diss_林_直樹_ISK567_2020","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/15247/files/Diss_林_直樹_ISK567_2020.pdf"},"version_id":"0dd09545-9338-4a29-af3d-eec1bbdcc393"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-05-07"}],"displaytype":"detail","filename":"Abstract_林_直樹_4514810200_2020.pdf","filesize":[{"value":"145.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Abstract_林_直樹_4514810200_2020","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/15247/files/Abstract_林_直樹_4514810200_2020.pdf"},"version_id":"d0abecc7-a02d-455d-9d3c-ab2a56164e53"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-08-19"}],"displaytype":"detail","filename":"Result_Hayashi_Naoki_isk_567.pdf.pdf","filesize":[{"value":"907.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Result_Hayashi_Naoki_isk_567","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/15247/files/Result_Hayashi_Naoki_isk_567.pdf.pdf"},"version_id":"5b7c0a98-af29-438b-b328-9abc7770d209"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-08-19"}],"displaytype":"detail","filename":"Comments_Hayashi_Naoki_isk_567.pdf","filesize":[{"value":"436.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_Hayashi_Naoki_isk_567","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/15247/files/Comments_Hayashi_Naoki_isk_567.pdf"},"version_id":"80ebf383-e21c-4c16-bf27-b008c8e1facc"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"single nucleotide polymorphism","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"somatic mutation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"disease risk","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"quality of life","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"healthy longevity","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"A clinical trial of somatic and germline analyses for healthy longevity in a postoperative cancer patient","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A clinical trial of somatic and germline analyses for healthy longevity in a postoperative cancer patient","subitem_title_language":"en"},{"subitem_title":"術後癌患者における健康寿命を目的として体細胞変異や生殖細胞変異を解析する臨床試験","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-08-19"},"publish_date":"2020-08-19","publish_status":"0","recid":"15247","relation_version_is_last":true,"title":["A clinical trial of somatic and germline analyses for healthy longevity in a postoperative cancer patient"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T01:58:06.970571+00:00"}