{"created":"2023-07-25T08:14:26.286823+00:00","id":15471,"links":{},"metadata":{"_buckets":{"deposit":"026e3682-d081-41ec-a1ac-e6cf4721c222"},"_deposit":{"created_by":18,"id":"15471","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"15471"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00015471","sets":["57:86"]},"author_link":["137424"],"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2020-08-06","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2020-08-20"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(歯学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Dental Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Streptococcus mutans is a major cause of tooth decay due to its promotion of biofilm formation and acid production. Several plant extracts have been reported to have multiple biological activities such as anti‐inflammation and antibacterial effects. This study investigated the antibacterial activity of three plant extracts, phellodendron bark (PB), yucca, and black ginger, and found that PB had a stronger effect than the other extracts. Then, the minimum inhibitory concentration (MIC) of PB against 100 S. mutans strains was investigated. The MIC range of PB was 9.8–312.5 µg/mL. PB suppressed the growth kinetics of S. mutans in a dose‐dependent manner, even at sub‐MICs of PB. Then, we investigated the effect of PB on S. mutans virulence. The PB suppressed biofilm formation at high concentrations, although PB did not affect the expression of glucosyltransferase genes. Additionally, PB suppressed the decrease in pH from adding an excess of glucose. The expression of genes responsible for acid production was increased by the addition of excess glucose without PB, whereas their expression levels were not increased in the presence of 1× and 2× MIC of PB. Although PB showed a bacteriostatic effect on planktonic S. mutans cells, it was found that more than 2× MIC of PB showed a partial bactericidal effect on biofilm cells. In conclusion, PB not only showed antibacterial activity against S. mutans but also decreased the cariogenic activity in S. mutans.\n\nToshiya Tsujii, Miki Kawada‐Matsuo, Hirono Migita, Kouji Ohta, Yuichi Oogai, Youichi Yamasaki, Hitoshi Komatsuzawa\nAntibacterial activity of phellodendron bark against Streptococcus mutans\nMicrobiology and  Immunology 64(6) p.424-434  2020\nhttps://doi.org/10.1111/1348-0421.12787","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第569号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"The Societies and John Wiley & Sons","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:山﨑要一】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2020-06-03"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"辻井, 利弥","creatorNameLang":"ja"},{"creatorName":"ツジイ, トシヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Tsujii, Toshiya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"137424","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-05-13"}],"displaytype":"detail","filename":"Diss_辻井_利弥_ISK569_2020.pdf","filesize":[{"value":"496.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Diss_辻井_利弥_ISK569_2020","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/15471/files/Diss_辻井_利弥_ISK569_2020.pdf"},"version_id":"ca355b04-ed84-49d9-b8a0-54fadda5a394"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-05-13"}],"displaytype":"detail","filename":"Abstract_辻井_利弥_4516800089_2020.pdf","filesize":[{"value":"30.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Abstract_辻井_利弥_4516800089_2020","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/15471/files/Abstract_辻井_利弥_4516800089_2020.pdf"},"version_id":"9e65d0a9-19bd-4c44-b4f2-3e7ce7193e80"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-01"}],"displaytype":"detail","filename":"Result_Tsujii_Toshiya_isk_569.pdf","filesize":[{"value":"169.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Result_Tsujii_Toshiya_isk_569","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/15471/files/Result_Tsujii_Toshiya_isk_569.pdf"},"version_id":"cf6bc227-da1d-43c3-bc4e-4df843acb00e"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-01"}],"displaytype":"detail","filename":"Comments_Tsujii_Toshiya_isk_569.pdf","filesize":[{"value":"88.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_Tsujii_Toshiya_isk_569","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/15471/files/Comments_Tsujii_Toshiya_isk_569.pdf"},"version_id":"d8daf201-50ea-4202-bc37-4ca2075eb7c3"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"antibacterial agents and chemotherapy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"bacteriology","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"pathogenesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Streptococcus mutans","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Antibacterial　activity of phellodendron bark against Streptococcus mutans","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Antibacterial　activity of phellodendron bark against Streptococcus mutans","subitem_title_language":"en"},{"subitem_title":"オウバクの Streptococcus mutans に対する抗菌効果","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-10-01"},"publish_date":"2020-10-01","publish_status":"0","recid":"15471","relation_version_is_last":true,"title":["Antibacterial　activity of phellodendron bark against Streptococcus mutans"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T01:58:14.461871+00:00"}