{"created":"2023-07-25T08:14:26.933133+00:00","id":15485,"links":{},"metadata":{"_buckets":{"deposit":"02a56d18-7b89-4299-9665-156db7ae3f6a"},"_deposit":{"created_by":18,"id":"15485","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"15485"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00015485","sets":["57:86"]},"author_link":["137459"],"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2020-09-04","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2020-09-16"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Background/Aim: Adult T-cell leukemia (ATL) is a hematological malignancy caused by infection with human T-cell leukemia virus type 1 (HTLV-1). Chemotherapy, antibody therapy, and bone marrow transplantation are used to treat this disease, however, median survival time has not been significantly improved. Our aim was to develop and evaluate a novel antibody-drug conjugate (ADC) with regards to cell cytotoxicity and target specificity. Materials and Methods: In this study, we have constructed a novel ADC, which is composed of an anti-CD70 single chain Fv-Fc antibody conjugated with the anticancer agent emtansine using a novel antibody modification method. Cell cytotoxicity and target specificity were assessed using a cell proliferation assay. Results: The anti-CD70 ADC selectively killed HTLV-1-infected cells and ATL cells without affecting other cells. Conclusion: The anti-CD70 ADC offers some chemotherapeutic potential for the treatment of ATL.\n\nRIRI YOKOTA, SHUN HASHIMOTO, IKUKO WATANABE, SATOSHI KISHIMOTO, MASAAKI TOYAMA, MIKA OKAMOTO, MAKOTO YOSHIMITSU, KENJI ISHITSUKA, YUJI ITO and MASANORI BABA\nNovel Anti-CD70 Antibody Drug Conjugate for the Treatment of Adult T-Cell Leukemia (ATL)\nAnticancer Research 40(8): 4471-4479 (2020)\nhttps://doi.org/10.21873/anticanres.14452","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第576号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"International Institute of Anticancer Research","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:馬場昌範】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2020-08-05"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"横田, 璃里","creatorNameLang":"ja"},{"creatorName":"ヨコタ, リリ","creatorNameLang":"ja-Kana"},{"creatorName":"Yokota, Riri","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-08-09"}],"displaytype":"detail","filename":"Diss_横田_璃里_ISK576_2020.pdf","filesize":[{"value":"2.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Diss_横田_璃里_ISK576_2020","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/15485/files/Diss_横田_璃里_ISK576_2020.pdf"},"version_id":"eabe3e20-c8db-4051-b8e8-57d5ca46a7ef"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-08-04"}],"displaytype":"detail","filename":"Abstract_横田_璃里_4517800154_2020.pdf","filesize":[{"value":"22.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Abstract_横田_璃里_4517800154_2020","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/15485/files/Abstract_横田_璃里_4517800154_2020.pdf"},"version_id":"e8e4a1e4-3f80-41a2-a15e-a6cb3d53779b"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-05"}],"displaytype":"detail","filename":"Result_Yokota_Riri_isk_576.pdf","filesize":[{"value":"779.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Result_Yokota_Riri_isk_576","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/15485/files/Result_Yokota_Riri_isk_576.pdf"},"version_id":"c6fa7946-06fe-4e04-8295-260b0db95796"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-05"}],"displaytype":"detail","filename":"Comments_Yokota_Riri_isk_576.pdf","filesize":[{"value":"494.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_Yokota_Riri_isk_576","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/15485/files/Comments_Yokota_Riri_isk_576.pdf"},"version_id":"f7106130-e861-4408-bd5c-54e6ebd694f5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ATL","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"HTLV-1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"antibody drug conjugate","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cancer chemotherapy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Immunotherapy","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Novel Anti-CD70 Antibody Drug Conjugate for the Treatment of Adult T-Cell Leukemia (ATL)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Novel Anti-CD70 Antibody Drug Conjugate for the Treatment of Adult T-Cell Leukemia (ATL)","subitem_title_language":"en"},{"subitem_title":"成人T細胞白血病(ATL)の治療に向けた新規抗CD70抗体薬物複合体の開発","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-10-05"},"publish_date":"2020-10-05","publish_status":"0","recid":"15485","relation_version_is_last":true,"title":["Novel Anti-CD70 Antibody Drug Conjugate for the Treatment of Adult T-Cell Leukemia (ATL)"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T01:58:33.811199+00:00"}