{"created":"2023-07-25T08:14:33.648026+00:00","id":15626,"links":{},"metadata":{"_buckets":{"deposit":"78a45859-069c-42d4-8559-45a2e311880d"},"_deposit":{"created_by":18,"id":"15626","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"15626"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00015626","sets":["57:86"]},"author_link":["138181"],"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2020-11-05","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2020-11-13"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(歯学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Dental Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"LL-37, the only member of the cathelicidin family of cationic antimicrobial peptides in humans has been shown to exhibit a wide variety of biological actions in addition to its antimicrobial activity. However, the lymphangiogenic effect of LL-37 has not been elucidated yet. In this study, we examined the effects of LL-37 on lymphangiogenesis and evaluated the underlying molecular mechanisms. LL-37 treatment significantly increased the migration and tube-like formation of human dermal lymphatic microvascular endothelial cells (HDLECs) and promoted the expression of lymphangiogenic factor in HDLECs. Treatment with LL-37 increased phosphorylation of ERK and Akt proteins in HDLECs, and pretreatment with ERK and Akt inhibitors significantly blocked the LL-37-induced HDLEC migration and tube-like formation. Furthermore, to investigate the involvement of formyl peptide receptor-like 1 (FPRL1) signaling in LL-37-induced lymphangiogenesis, HDLECs were treated with an FPRL1 antagonist. Pretreatment with the FPRL1 antagonist inhibited LL-37-induced phosphorylation of ERK and Akt proteins and attenuated LL-37-induced HDLEC migration and tube-like formation. These data indicated that LL-37 induces lymphangiogenesis in lymphatic endothelial cells via FPRL1, and the activation of the ERK and Akt-dependent signaling pathways.\n\nTakahiro Yanagisawa, Masakazu Ishii, Manami Takahashi, Kei Fujishima & Masahiro Nishimura \nHuman cathelicidin antimicrobial peptide LL-37 promotes lymphangiogenesis in lymphatic endothelial cells through the ERK and Akt signaling pathways\nMolecular Biology Reports volume 47, pages6841–6854 (2020)\nThis is a post-peer-review, pre-copyedit version of an article published in Molecular Biology Reports . \nThe final authenticated version is available online at: \nhttps://doi.org/10.1007/s11033-020-05741-8","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第579号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Springer","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:西村正宏】 "}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2020-10-07"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"柳澤, 嵩大","creatorNameLang":"ja"},{"creatorName":"ヤナギサワ, タカヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Yanagisawa, Takahiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-10-21"}],"displaytype":"detail","filename":"Diss_柳澤_嵩大_ISK579_2020.pdf","filesize":[{"value":"834.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Diss_柳澤_嵩大_ISK579_2020","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/15626/files/Diss_柳澤_嵩大_ISK579_2020.pdf"},"version_id":"1196c04a-47d2-45c7-9b03-157be5a5d4e9"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-09"}],"displaytype":"detail","filename":"Abstract_柳澤_嵩大_4516810414_2020.pdf","filesize":[{"value":"24.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Abstract_柳澤_嵩大_4516810414_2020","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/15626/files/Abstract_柳澤_嵩大_4516810414_2020.pdf"},"version_id":"9e8858d9-de1b-49f5-b412-6244a28dd351"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-03"}],"displaytype":"detail","filename":"Result_Yanagisawa_Takahiro_isk_579.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Result_Yanagisawa_Takahiro_isk_579","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/15626/files/Result_Yanagisawa_Takahiro_isk_579.pdf"},"version_id":"541211d3-0525-4f88-83a5-bf7ac07cecdd"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-03"}],"displaytype":"detail","filename":"Comments_Yanagisawa_Takahiro_isk_579.pdf","filesize":[{"value":"492.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_Yanagisawa_Takahiro_isk_579","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/15626/files/Comments_Yanagisawa_Takahiro_isk_579.pdf"},"version_id":"2bc0df9c-679f-41a2-a9a4-732eefd8ddb2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"LL-37","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Lymphangiogenesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ERK","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Akt","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"FPRL1","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Human Cathelicidin Antimicrobial Peptide LL-37 Promotes Lymphangiogenesis in Lymphatic Endothelial Cells through the ERK and Akt Signaling Pathways","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Human Cathelicidin Antimicrobial Peptide LL-37 Promotes Lymphangiogenesis in Lymphatic Endothelial Cells through the ERK and Akt Signaling Pathways","subitem_title_language":"en"},{"subitem_title":"ヒトカテリシジン抗菌性ペプチドLL-37はERK及びAktシグナル伝達経路を介してリンパ管内皮細胞によるリンパ管新生を促進する","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-12-03"},"publish_date":"2020-12-03","publish_status":"0","recid":"15626","relation_version_is_last":true,"title":["Human Cathelicidin Antimicrobial Peptide LL-37 Promotes Lymphangiogenesis in Lymphatic Endothelial Cells through the ERK and Akt Signaling Pathways"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T01:58:48.238148+00:00"}