{"created":"2023-07-25T08:14:42.854853+00:00","id":15839,"links":{},"metadata":{"_buckets":{"deposit":"e9fe26e1-75f9-41d9-b457-ebf6ef2f6bdb"},"_deposit":{"created_by":18,"id":"15839","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"15839"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00015839","sets":["57:86"]},"author_link":["139395"],"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2021-03-10","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2021-03-17"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Background: In the intensive care unit (ICU), patients with thrombocytopenia are at high risk for bleeding and should be assessed for their thrombogenic potential. However, the analytical conditions of conventional hemostatic tests are unsuitable for the evaluation of low-platelet samples. Here we aimed to establish suitable analytical conditions with the Total Thrombus-formation Analysis System (T-TAS) for quantitative assessment of thrombogenic potential in patients with thrombocytopenia and to investigate how T-TAS values relate to bleeding symptoms and the effects of platelet transfusion.\nMethods: Modified chips with a different chamber depth were developed for the analysis of low-platelet samples in the T-TAS. We included 10 adult patients admitted to the ICU of Kagoshima University Hospital who required platelet transfusion. Patients were divided into major and minor bleeding groups according to their bleeding scale before platelet transfusion. The thrombogenic potential of these patients before and after platelet transfusion was assessed with hemostatic function tests, including rotational thromboelastometry, multiplate aggregometry, and the T-TAS.\nResults: Analysis of low-platelet samples revealed that, compared with the conventional chip (80-μm-deep chamber), the modified chip (50-μm-deep chamber) achieved higher sensitivity in detecting elevation of flow pressure caused by growth of an occlusive thrombus in the T-TAS analytical chamber. All patients in the minor bleeding group retained thrombogenic potential that occluded the modified chip (occlusion time 16.3 ± 3.3 min), whereas most patients in the major bleeding group were unable to occlude the modified chip during the 30-min measurement (P< 0.01). The recovery of thrombogenic potential after platelet transfusion was confirmed with the T-TAS and correlated with the function, rather than the count, of transfused platelets. Among all evaluated parameters in hemostatic function tests, only the T-TAS showed significant differences in occlusion time and area under the curve both between the minor and major bleeding groups and between pre- and post-platelet transfusion.\nConclusions: We developed a modified microchip-based flow chamber system that reflects the hemostatic function of patients with thrombocytopenia.\n\nBengo Atari, Takashi Ito, Tomoka Nagasato, Tomoko Ohnishi, Kazuya Hosokawa, Tomotsugu Yasuda, Ikuro Maruyama and Yasuyuki Kakihana\nA modified microchip-based flow chamber system for evaluating thrombogenicity in patients with thrombocytopenia\nThrombosis Journal volume 18, Article number: 31 (2020)\nhttps://doi.org/10.1186/s12959-020-00244-9","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第594号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:垣花泰之】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2020-12-02"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中, 弁護","creatorNameLang":"ja"},{"creatorName":"アタリ, ベンゴ","creatorNameLang":"ja-Kana"},{"creatorName":"Atari, Bengo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"139395","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-09-29"}],"displaytype":"detail","filename":"Diss_中_弁護_ISK594_2020.pdf","filesize":[{"value":"1.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Diss_中_弁護_ISK594_2020","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/15839/files/Diss_中_弁護_ISK594_2020.pdf"},"version_id":"dc862a5a-4ed8-42b3-8761-675eb25249e2"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-09-29"}],"displaytype":"detail","filename":"Abstract_中_弁護_4517810016_2020.pdf","filesize":[{"value":"178.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Abstract_中_弁護_4517810016_2020","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/15839/files/Abstract_中_弁護_4517810016_2020.pdf"},"version_id":"8281c21f-1db8-47a1-a975-5eb8587e7f97"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-14"}],"displaytype":"detail","filename":"Result_Atari_Bengo_isk_594.pdf","filesize":[{"value":"176.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Result_Atari_Bengo_isk_594","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/15839/files/Result_Atari_Bengo_isk_594.pdf"},"version_id":"21bcd685-735c-435b-b4e3-1c7c4352d342"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-14"}],"displaytype":"detail","filename":"Comments_Atari_Bengo_isk_594.pdf","filesize":[{"value":"88.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_Atari_Bengo_isk_594","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/15839/files/Comments_Atari_Bengo_isk_594.pdf"},"version_id":"3008eefb-6f0a-49bd-856d-4940336a368e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Thrombocytopenia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Platelet transfusion","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Bleeding","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Flow chamber","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Total Thrombus-formation analysis system (T-TAS)","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"A modified microchip-based flow chamber system for evaluating thrombogenicity in patients with thrombocytopenia","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A modified microchip-based flow chamber system for evaluating thrombogenicity in patients with thrombocytopenia","subitem_title_language":"en"},{"subitem_title":"血小板減少症患者における血栓形成能を評価するための新規マイクロチップフローチャンバーシステム","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-04-14"},"publish_date":"2021-04-14","publish_status":"0","recid":"15839","relation_version_is_last":true,"title":["A modified microchip-based flow chamber system for evaluating thrombogenicity in patients with thrombocytopenia"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T01:59:30.951270+00:00"}