{"created":"2023-07-25T08:14:42.898750+00:00","id":15840,"links":{},"metadata":{"_buckets":{"deposit":"5604c215-f86e-4262-b5b2-b962603e3f4f"},"_deposit":{"created_by":18,"id":"15840","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"15840"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00015840","sets":["57:86"]},"author_link":["139398"],"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2021-03-10","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2021-03-25"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"BACKGROUND AND OBJECTIVE:\nTurbulent blood flow in patients with aortic valve stenosis (AS) results in morphological and functional changes in platelets and coagulation factors. The aim of this study is to determine how shear stress affects platelets and coagulation factors.\nMETHODS:\nWe retrospectively evaluated data from 78 patients who underwent AVR to treat AS between March 2008 and July 2017 at Kagoshima University Hospital.\nRESULTS:\nPlatelet (PLT) count obviously decreased at three days after AVR, and increased above preoperative levels at the time of discharge. In contrast, platelet distribution width (PDW), mean platelet volume (MPV), and platelet large cell ratio (P-LCR) increased three days after AVR, then decreased to below preoperative levels. No differences were evident between groups with higher (HPPG > 100 mmHg) and lower (LPPG < 100 mmHg) peak pressure gradients (PPG) before AVR, whereas PLT count, PDW, MPV and P-LCR improved more in the HPPG group. Plateletcrit (PCT), which represents the total volume of platelets, increased after AVR due to decreased shear stress. High increasing rate of PCT was associated with lower PLT count, higher PDW and lower fibrinogen.\nCONCLUSION:\nShear stress affects PLT count, PDW, and fibrinogen in patients with AS.\n\nKanda Hideaki, Yamakuchi Munekazu, Matsumoto Kazuhisa, Mukaihara Kosuke, Shigehisa Yoshiya, Tachioka Shuji, Okawa Masashi, Takenouchi Kazunori, Oyama Yoko, Hashiguchi Teruto, Imoto Yutaka\nDynamic changes in platelets caused by shear stress in aortic valve stenosis\nClinical Hemorheology and Microcirculation, 77(1), pp. 71-81, 2021\nThe final publication is available at IOS Press through https://doi.org/10.3233/CH-200928","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第595号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"IOS Press ","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:井本浩】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2021-02-03"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"上田, 英昭","creatorNameLang":"ja"},{"creatorName":"カンダ, ヒデアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Kanda, Hideaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-09-29"}],"displaytype":"detail","filename":"Diss_上田_英昭_ISK595_2020.pdf","filesize":[{"value":"817.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Diss_上田_英昭_ISK595_2020","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/15840/files/Diss_上田_英昭_ISK595_2020.pdf"},"version_id":"7b28ba89-4e63-4fe7-9a51-b2c9c67186be"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-09-29"}],"displaytype":"detail","filename":"Abstract_上田_英昭_4517810123_2020.pdf","filesize":[{"value":"24.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Abstract_上田_英昭_4517810123_2020","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/15840/files/Abstract_上田_英昭_4517810123_2020.pdf"},"version_id":"07774e9d-ff32-4c50-8b35-2cc17065f59e"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-14"}],"displaytype":"detail","filename":"Result_Kanda_Hideaki_isk_595.pdf","filesize":[{"value":"173.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Result_Kanda_Hideaki_isk_595","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/15840/files/Result_Kanda_Hideaki_isk_595.pdf"},"version_id":"19cea9e3-a1c8-4a55-a333-3b123bc5b5a1"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-14"}],"displaytype":"detail","filename":"Comments_Kanda_Hideaki_isk_595.pdf","filesize":[{"value":"91.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_Kanda_Hideaki_isk_595","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/15840/files/Comments_Kanda_Hideaki_isk_595.pdf"},"version_id":"9d6d5275-a3f9-4e95-b5e4-bce412ecbac1"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Aortic valve stenosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"platelet","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"plateletcrit","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"shear stress","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"pressure gradient","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Dynamic changes in platelets caused by shear stress in aortic valve stenosis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Dynamic changes in platelets caused by shear stress in aortic valve stenosis","subitem_title_language":"en"},{"subitem_title":"大動脈弁狭窄症におけるシアストレスによる血小板の動態","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-04-14"},"publish_date":"2021-04-14","publish_status":"0","recid":"15840","relation_version_is_last":true,"title":["Dynamic changes in platelets caused by shear stress in aortic valve stenosis"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T01:59:36.758670+00:00"}