{"created":"2023-07-25T08:14:44.601674+00:00","id":15878,"links":{},"metadata":{"_buckets":{"deposit":"c9aa2bd8-fe9b-447c-8524-c09ed2d1302d"},"_deposit":{"created_by":18,"id":"15878","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"15878"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00015878","sets":["57:86"]},"author_link":["139531"],"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2021-06-07","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2021-06-17"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Purpose: Total parenteral nutrition (TPN) sometimes induces parenteral nutrition-associated liver disease (PNALD). Hepatocyte growth factor (HGF) acts as a potent hepatocyte mitogen anti-inflammatory and antioxidant actions. We aimed to evaluate the effect of HGF on PNALD in a rat model of TPN.\nMethods: A catheter was placed in the right jugular vein for 7-day continuous TPN. All rats were divided into three groups: TPN alone (TPN group), TPN plus intravenous HGF at 0.3 mg/kg/day [TPN + HGF (low) group], and TPN plus HGF at 1.0 mg/kg/day [TPN + HGF (high) group]. On day 7, livers were harvested and the histology, inflammatory cytokines and apoptosis were evaluated.\nResults: Histologically, lipid droplets were apparent in the TPN group, but decreased in the TPN + HGF (low) and TPN + HGF (high) groups. The histological nonalcoholic fatty liver disease activity scores in the TPN + HGF (low) and TPN + HGF (high) groups were significantly lower than that in the TPN group (p < 0.01). There were no significant differences in the inflammatory cytokine levels of the three groups. The caspase-9 expression levels in the TPN + HGF (low) and TPN + HGF (high) groups were significantly decreased in comparison to that in the control group (p < 0.05).\nConclusion: The intravenous administration of HGF attenuated hepatic steatosis induced by 7-day TPN dose dependently.\n\nMakoto Matsukubo, Keisuke Yano, Tatsuru Kaji, Koshiro Sugita, Shun Onishi, Toshio Harumatsu, Ayaka Nagano, Mayu Matsui, Masakazu Murakami, Koji Yamada, Waka Yamada, Mitsuru Muto, Kotaro Kumagai, Akio Ido, Satoshi Ieiri\nThe administration of hepatocyte growth factor prevents total parenteral nutrition-induced hepatocellular injury in a rat model\nPediatric Surgery International (2021) 37:353–361\n\nThis version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at:\nhttps://doi.org/10.1007/s00383-020-04823-9","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第610号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:家入里志】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2021-04-07"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"松久保, 眞","creatorNameLang":"ja"},{"creatorName":"マツクボ, マコト","creatorNameLang":"ja-Kana"},{"creatorName":"Matsukubo, Makoto","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-07-04"}],"displaytype":"detail","filename":"Diss_松久保_眞_ISK610_2021.pdf","filesize":[{"value":"725.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Diss_松久保_眞_ISK610_2021","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/15878/files/Diss_松久保_眞_ISK610_2021.pdf"},"version_id":"4290f0fa-1016-4d99-9beb-1c6629058273"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-06-22"}],"displaytype":"detail","filename":"Abstract_松久保_眞_4517800136_2021.pdf","filesize":[{"value":"212.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Abstract_松久保_眞_4517800136_2021","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/15878/files/Abstract_松久保_眞_4517800136_2021.pdf"},"version_id":"db165b09-4912-4729-8c21-0186584a9856"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-06-22"}],"displaytype":"detail","filename":"Result_matukubo_makoto_isk610.pdf","filesize":[{"value":"1.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Result_matukubo_makoto_isk610","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/15878/files/Result_matukubo_makoto_isk610.pdf"},"version_id":"2fb86359-c4c9-4ed8-b666-1ec965a12d18"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-06-22"}],"displaytype":"detail","filename":"Comments_matukubo_makoto_isk610.pdf","filesize":[{"value":"473.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_matukubo_makoto_isk610","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/15878/files/Comments_matukubo_makoto_isk610.pdf"},"version_id":"a603107d-fd5a-40b6-9b09-b58f0100d233"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Total parenteral nutrition","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Steatosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Hepatocyte growth factor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"PNALD","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"NAFLD","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"The administration of hepatocyte growth factor prevents total parenteral nutrition‑induced hepatocellular injury in a rat model","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The administration of hepatocyte growth factor prevents total parenteral nutrition‑induced hepatocellular injury in a rat model","subitem_title_language":"en"},{"subitem_title":"ラットモデルに対する肝細胞増殖因子投与は、完全静脈栄養関連肝障害を予防する。","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-06-22"},"publish_date":"2021-06-22","publish_status":"0","recid":"15878","relation_version_is_last":true,"title":["The administration of hepatocyte growth factor prevents total parenteral nutrition‑induced hepatocellular injury in a rat model"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T02:04:47.358486+00:00"}