{"created":"2023-07-25T08:14:53.492445+00:00","id":16075,"links":{},"metadata":{"_buckets":{"deposit":"ca1a2f82-a3ff-45eb-8155-d8a1d6a25892"},"_deposit":{"created_by":18,"id":"16075","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"16075"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00016075","sets":["57:86"]},"author_link":["140598"],"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2021-12-06","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2021-12-15"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Patients with AN often express psychological symptoms such as body image distortion, cognitive biases, abnormal facial recognition, and deficits in working memory. However, the molecular mechanisms underlying the impairment of cognitive behaviors in AN remain unknown. In the present study, we measured cognitive behavior using novel object recognition (NOR) tasks and mRNA expressions in hypothalamic neuropeptides in female C57BL/6J mice with activity-based anorexia (ABA). Additionally, we evaluated the effects of antagonists with intracerebroventricular (icv) administration on the impairment of cognitive behavior in NOR tasks. Our results showed that NOR indices were lowered, subsequently increasing mRNA levels of agouti-related peptide (AgRP) and neuropeptide Y (NPY), and c-Fos- and AgRP- or NPY-positive cells in the hypothalamic arcuate nucleus in ABA mice. We also observed that icv administration of anti-NPY antiserum (2 µl), anti-AgRP antibody (0.1 μg), and Y5 receptor antagonist CPG71683 (15 nmol) significantly reversed the decreased NOR indices. Therefore, our results suggest that increased NPY and AgRP signaling in the brain might contribute to the impairment of cognitive behavior in AN.\n\nNatasya Trivena Rokota, Koji Ataka, Haruki Iwai, Hajime Suzuki, Homare Tachibe, Timothy Sean Kairupan, Kai-Chun Cheng, Haruka Amitani, Akio Inui, Akihiro Asakawa\nAntagonism for NPY signaling reverses cognitive behavior defects induced by activity-based anorexia in mice\nPsychoneuroendocrinology 126 (2021) 105133\nhttps://doi.org/10.1016/j.psyneuen.2021.105133","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第624号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:浅川明弘】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2021-08-04"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Rokot,  Trivena Natasya","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-12-01"}],"displaytype":"detail","filename":"Diss_ナターシャ_ロコット_ISK624_2021.pdf","filesize":[{"value":"958.8 kB"}],"format":"application/pdf","licensefree":"Copyright©2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Diss_ナターシャ_ロコット_ISK624_2021","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/16075/files/Diss_ナターシャ_ロコット_ISK624_2021.pdf"},"version_id":"1781ea11-5158-41c9-9d0e-a1f8768a0aac"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-06-14"}],"displaytype":"detail","filename":"Abstract_ナターシャ_ロコット_4515800155_2021.pdf","filesize":[{"value":"194.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Abstract_ナターシャ_ロコット_4515800155_2021","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/16075/files/Abstract_ナターシャ_ロコット_4515800155_2021.pdf"},"version_id":"1fedd256-c5c6-4442-aea4-01ed6657793a"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-23"}],"displaytype":"detail","filename":"Result_Natasya_Trivena_Rokot_isk_624.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Result_Natasya_Trivena_Rokot_isk_624","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/16075/files/Result_Natasya_Trivena_Rokot_isk_624.pdf"},"version_id":"f842a063-9195-4804-8921-2cc328b05c58"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-23"}],"displaytype":"detail","filename":"Comments_Natasya_Trivena_Rokot_isk_624.pdf","filesize":[{"value":"382.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_Natasya_Trivena_Rokot_isk_624","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/16075/files/Comments_Natasya_Trivena_Rokot_isk_624.pdf"},"version_id":"5d6e646a-88db-45d1-a320-9fbc818309c3"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Anorexia nervosa","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cognitive behavior","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Agouti-related peptide","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Neuropeptide Y","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Y5 receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Antagonism for NPY signaling reverses cognitive behavior defects induced by activity-based anorexia in mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Antagonism for NPY signaling reverses cognitive behavior defects induced by activity-based anorexia in mice","subitem_title_language":"en"},{"subitem_title":"神経ペプチドYのシグナル伝達系の拮抗は、活動性拒食症モデルマウスにおける認識機能低下を改善する","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-05-23"},"publish_date":"2022-05-23","publish_status":"0","recid":"16075","relation_version_is_last":true,"title":["Antagonism for NPY signaling reverses cognitive behavior defects induced by activity-based anorexia in mice"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T02:05:38.702032+00:00"}