{"created":"2023-07-25T08:14:53.580250+00:00","id":16077,"links":{},"metadata":{"_buckets":{"deposit":"bcef9e57-0f7d-4492-8a02-05c700bcc366"},"_deposit":{"created_by":18,"id":"16077","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"16077"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00016077","sets":["57:86"]},"author_link":["140602"],"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2021-12-06","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2021-12-15"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(歯学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Dental Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Oral microbiota is reportedly associated with gut microbiota and influences colorectal cancer (CRC) progression; however, the details remain unclear. This study aimed to evaluate the role of oral microbiota in CRC progression. Fifty-two patients with CRC and 51 healthy controls were included. Saliva and stool samples were collected, and microbiota were evaluated using 16S rRNA analysis and next-generation sequencing. Comparative analysis was performed on both groups. Linear discriminant analysis effect size (LEfSe) revealed the presence of indigenous oral bacteria, such as Peptostreptococcus, Streptococcus, and Solobacterium spp., at a significantly higher relative abundance in saliva and stool samples of CRC patients compared with controls. Next, CRC patients were divided into early stage (Stage I, II; n = 26; 50%) and advanced stage (Stage III, IV; n = 26; 50%) disease. LEfSe revealed that S. moorei was present at a significantly higher relative abundance in the advanced-stage group compared with the early-stage group, again consistent for both saliva and stool samples. Among bacterial species with significantly higher relative abundance in CRC patients, P. stomatis, S. anginosus, S. koreensis, and S. moorei originated from the oral cavity, suggesting indigenous oral bacteria may have promoted initiation of CRC carcinogenesis. Furthermore, S. moorei may influence CRC progression.\n\nYoshinori Uchino, Yuichi Goto, Yusuke Konishi, Kan Tanabe, Hiroko Toda,  Masumi Wada, Yoshiaki Kita, Mahiro Beppu, Shinichiro Mori, Hiroshi Hijioka, Takao Otsuka, Shoji Natsugoe, Eiji Hara, Tsuyoshi Sugiura\nColorectal Cancer Patients Have Four Specific Bacterial Species in Oral and Gut Microbiota in Common : A Metagenomic Comparison with Healthy Subjects\nCancers 2021, 13(13), 3332\nhttps://doi.org/10.3390/cancers13133332","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第626号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:杉浦剛】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2021-09-01"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"内野, 祥徳","creatorNameLang":"ja"},{"creatorName":"ウチノ, ヨシノリ","creatorNameLang":"ja-Kana"},{"creatorName":"Uchino, Yoshinori","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-06-16"}],"displaytype":"detail","filename":"Diss_内野_祥徳_ISK626_2021.pdf","filesize":[{"value":"3.1 MB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"Diss_内野_祥徳_ISK626_2021","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/16077/files/Diss_内野_祥徳_ISK626_2021.pdf"},"version_id":"c41f3650-aac6-4a30-bb73-a8e6fca63da9"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-06-14"}],"displaytype":"detail","filename":"Abstract_内野_祥徳_4517810071_2021.pdf","filesize":[{"value":"135.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Abstract_内野_祥徳_4517810071_2021","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/16077/files/Abstract_内野_祥徳_4517810071_2021.pdf"},"version_id":"12fc3d32-1ca3-4e4b-9ee8-060208dc67b9"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-23"}],"displaytype":"detail","filename":"Result_Uchino_Yoshinori_isk_626.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Result_Uchino_Yoshinori_isk_626","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/16077/files/Result_Uchino_Yoshinori_isk_626.pdf"},"version_id":"9010eb90-2864-4091-a9e9-30e4717a5694"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-23"}],"displaytype":"detail","filename":"Comments_Uchino_Yoshinori_isk_626.pdf","filesize":[{"value":"488.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_Uchino_Yoshinori_isk_626","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/16077/files/Comments_Uchino_Yoshinori_isk_626.pdf"},"version_id":"24f5ae11-e11f-453e-bcd5-a426cf1dcecf"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"microbiota","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"oral bacteria","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"colorectal cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Peptostreptococcus","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Streptococcus","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Solobacterium spp.","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Colorectal Cancer Patients Have Four Specific Bacterial Species in Oral and Gut Microbiota in Common : A Metagenomic Comparison with Healthy Subjects","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Colorectal Cancer Patients Have Four Specific Bacterial Species in Oral and Gut Microbiota in Common : A Metagenomic Comparison with Healthy Subjects","subitem_title_language":"en"},{"subitem_title":"大腸がん患者は口腔・腸内細菌叢に共通して4種の特異な菌種を有する : メタゲノム解析による健常者との比較","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-05-23"},"publish_date":"2022-05-23","publish_status":"0","recid":"16077","relation_version_is_last":true,"title":["Colorectal Cancer Patients Have Four Specific Bacterial Species in Oral and Gut Microbiota in Common : A Metagenomic Comparison with Healthy Subjects"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T02:05:44.276721+00:00"}