{"created":"2023-07-25T08:14:53.666460+00:00","id":16079,"links":{},"metadata":{"_buckets":{"deposit":"3def3a50-2051-4eab-ac7a-f527ee6b9020"},"_deposit":{"created_by":18,"id":"16079","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"16079"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00016079","sets":["57:86"]},"author_link":["140608"],"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2022-01-11","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2022-01-18"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"The free fatty acid receptor 1 (FFAR1) is suggested to function as a G protein-coupled receptor (GPR40) for medium-to-long-chain free fatty acids. Previous studies on the expression of FFAR1 revealed that the nigrostriatal region is one of the areas which express abundant FFAR1 mRNA/protein in the central nervous system (CNS). However, the role of FFAR1 in the CNS has been still largely unclarified. Here, we examined a possible functional role of FFAR1 in the control of extracellular concentrations of striatal monoamines and cocaine-induced locomotor activity. Microdialysis analysis revealed that the basal level of extracellular dopamine (DA) was significantly elevated, while the basal serotonin (5-HT) level tended to be reduced in the striatum of FFAR1 knockout (−/−) mice. Interestingly, local application of a FFAR1 agonist, GW9508, markedly augmented the striatal 5-HT release in FFAR1 wild-type (+/+) mice, whereas topical application of a FFAR1 antagonist, GW1100, significantly reduced the 5-HT release. However, the enhanced 5-HT release was completely lost in −/− mice. Although acute administration of cocaine enhanced the locomotor activity in both +/+ and −/− mice, the magnitude of the enhancement was significantly reduced in −/− mice. In addition, intraperitoneal injection of GW1100 significantly decreased the cocaine-induced locomotor enhancement. These results suggest that FFAR1 has a facilitatory role in striatal 5-HT release, and the evoked 5-HT release might contribute to enhance cocaine-induced locomotor activity.\n\nYuko Sadamura, Shanta Thapa, Ryota Mizunuma, Yuki Kambe, Akira Hirasawa, Kazuo Nakamoto, Shogo Tokuyama, Koji Yoshimoto, Kazunori Arita, Atsuro Miyata, Tatsuki Oyoshi, Takashi Kurihara\nFFAR1/GPR40 Contributes to the Regulation of Striatal Monoamine Releases and Facilitation of Cocaine-Induced Locomotor Activity in Mice\nFrontiers in Pharmacology 12, 699026, 2021\nhttps://doi.org/10.3389/fphar.2021.699026","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第627号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Frontiers","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:吉本幸司】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2021-11-14"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"貞村, 祐子","creatorNameLang":"ja"},{"creatorName":"サダムラ, ユウコ","creatorNameLang":"ja-Kana"},{"creatorName":"Sadamura, Yuko","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-06-17"}],"displaytype":"detail","filename":"Diss_貞村_祐子_ISK627_2021.pdf","filesize":[{"value":"2.2 MB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"Diss_貞村_祐子_ISK627_2021","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/16079/files/Diss_貞村_祐子_ISK627_2021.pdf"},"version_id":"903b4fdb-d126-4de1-bd48-9a005a97b3d1"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-06-14"}],"displaytype":"detail","filename":"Abstract_貞村_祐子_4512810013_2021.pdf","filesize":[{"value":"158.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Abstract_貞村_祐子_4512810013_2021","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/16079/files/Abstract_貞村_祐子_4512810013_2021.pdf"},"version_id":"eddb4d18-7914-4358-8846-3373d443db63"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-23"}],"displaytype":"detail","filename":"Result_Sadamura_Yuko_isk_627.pdf","filesize":[{"value":"5.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Result_Sadamura_Yuko_isk_627","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/16079/files/Result_Sadamura_Yuko_isk_627.pdf"},"version_id":"8939192f-a053-44b0-ad39-31304466c186"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-23"}],"displaytype":"detail","filename":"Comments_Sadamura_Yuko_isk_627.pdf","filesize":[{"value":"2.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_Sadamura_Yuko_isk_627","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/16079/files/Comments_Sadamura_Yuko_isk_627.pdf"},"version_id":"135d42ee-ee72-45da-bf0b-b380e88ffa57"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"FFAR1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"GPR40","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"serotonin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"5-HT","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cocaine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"locomotor activity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"striatum","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"FFAR1/GPR40 Contributes to the Regulation of Striatal Monoamine Releases and Facilitation of Cocaine-Induced Locomotor Activity in Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"FFAR1/GPR40 Contributes to the Regulation of Striatal Monoamine Releases and Facilitation of Cocaine-Induced Locomotor Activity in Mice","subitem_title_language":"en"},{"subitem_title":"FFAR1/GPR40はマウス線条体におけるモノアミン放出の調節およびコカイン誘発移所運動活性亢進に寄与している","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-05-23"},"publish_date":"2022-05-23","publish_status":"0","recid":"16079","relation_version_is_last":true,"title":["FFAR1/GPR40 Contributes to the Regulation of Striatal Monoamine Releases and Facilitation of Cocaine-Induced Locomotor Activity in Mice"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T02:05:49.346609+00:00"}