{"created":"2023-07-25T08:14:53.709864+00:00","id":16080,"links":{},"metadata":{"_buckets":{"deposit":"32f569da-ac2b-4f81-aeea-37e8a4496d77"},"_deposit":{"created_by":18,"id":"16080","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"16080"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00016080","sets":["57:86"]},"author_link":["140611"],"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2022-01-11","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2022-01-18"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(歯学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Dental Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Management of time and circadian disruption is an extremely important factor in basic research on pain and analgesia. Although pain is known to vary throughout the day, the mechanism underlying this circadian variation remains largely unknown. In this study, we hypothesized that the process of pain transmission to the central nervous system (after receiving nociceptive stimuli from outside the body) would show day-night differences. Ten-week-old male mice were kept under a strict 12/12-h light/dark cycle for at least 10 days. Formalin was then injected into the second branch region of the trigeminal nerve and the duration of pain-related behaviors (PRBs) was assessed. Immunohistochemical staining was then performed, and the c-Fos-immunopositive cells in the trigeminal spinal tract subnucleus caudalis (Sp5C) were counted. The results showed that the duration of PRBs was longer and the number of c-Fos immunopositive cells in the Sp5C was higher at nighttime than during the day. In addition, the trigeminal ganglia (TG) were extracted from the mice and examined by quantitative real-time PCR to evaluate the daytime and nighttime expression of nociceptive receptors. The results showed that the mRNA expression of transient receptor potential ankyrin 1 in the TG was significantly higher at night than during the day. These results suggest that pain in the trigeminal nerve region is more intense at nighttime, when rodents are active, than during the daytime, partly due to differences in nociceptor expression.\n\nAyako Niiro, Sachi N. Ohno, Kanae A. Yamagata, Kazuaki Yamagata, Kazuo Tomita, Eriko Kuramoto, Yoshiaki Oda, Takahiro J. Nakamura, Wataru Nakamura, Mitsutaka Sugimura\nDiurnal Variation in Trigeminal Pain Sensitivity in Mice\nFrontiers in Neuroscience 15, 703440, 2021\nhttps://doi.org/10.3389/fnins.2021.703440","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第628号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Frontiers","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:杉村光隆】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2021-11-14"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"新納, 彩子","creatorNameLang":"ja"},{"creatorName":"ニイロ, アヤコ","creatorNameLang":"ja-Kana"},{"creatorName":"Niiro, Ayako","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-06-17"}],"displaytype":"detail","filename":"Diss_新納_彩子_ISK628_2021.pdf","filesize":[{"value":"4.7 MB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"Diss_新納_彩子_ISK628_2021","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/16080/files/Diss_新納_彩子_ISK628_2021.pdf"},"version_id":"2a7bfee5-01ed-458a-b993-8de92037f8ad"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-06-14"}],"displaytype":"detail","filename":"Abstract_新納_彩子_4517810286_2021.pdf","filesize":[{"value":"33.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Abstract_新納_彩子_4517810286_2021","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/16080/files/Abstract_新納_彩子_4517810286_2021.pdf"},"version_id":"247aa3b8-1735-41d1-abde-2f6c4354ab05"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-23"}],"displaytype":"detail","filename":"Result_Niiro_Ayako_isk_628.pdf","filesize":[{"value":"5.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Result_Niiro_Ayako_isk_628","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/16080/files/Result_Niiro_Ayako_isk_628.pdf"},"version_id":"df249203-e4c7-495f-bc7d-0f2291ad276e"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-23"}],"displaytype":"detail","filename":"Comments_Niiro_Ayako_isk_628.pdf","filesize":[{"value":"2.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_Niiro_Ayako_isk_628","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/16080/files/Comments_Niiro_Ayako_isk_628.pdf"},"version_id":"73f4ea5a-c031-4350-8243-4f11b5247db2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"pain","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"day-night difference","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"formalin test","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"trigeminal nervous system","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"TRPA1","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Diurnal variation in trigeminal pain sensitivity in mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Diurnal variation in trigeminal pain sensitivity in mice","subitem_title_language":"en"},{"subitem_title":"マウスの三叉神経支配領域における痛みの日内変動","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-05-23"},"publish_date":"2022-05-23","publish_status":"0","recid":"16080","relation_version_is_last":true,"title":["Diurnal variation in trigeminal pain sensitivity in mice"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T02:05:49.299846+00:00"}