{"created":"2023-07-25T08:14:53.752576+00:00","id":16081,"links":{},"metadata":{"_buckets":{"deposit":"32619afb-f792-4f42-91fa-c8796842b8ec"},"_deposit":{"created_by":18,"id":"16081","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"16081"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00016081","sets":["57:86"]},"author_link":["140614"],"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2022-01-11","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2022-01-18"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(歯学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Dental Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Linalool odor exposure induces an analgesic effect in mice. This effect disappeared in the anosmic model mice, indicating that olfactory input evoked by linalool odor triggered this effect. Furthermore, hypothalamic orexinergic neurons play a pivotal role in this effect. However, the neuronal circuit mechanisms underlying this effect have not been fully addressed. In this study, we focused on the descending orexinergic projection to the spinal cord and examined whether this pathway contributes to the effect. We assessed the effect of intrathecal administration of orexin receptor antagonists on linalool odor-induced analgesia in the tail capsaicin test. We found that the selective orexin type 1 receptor antagonist, but not the selective orexin type 2 receptor antagonist, prevented the odor-induced analgesic effect. Furthermore, immunohistochemical analyses of c-Fos expression induced by the capsaicin test revealed that neuronal activity of spinal cord neurons was suppressed by linalool odor exposure, which was prevented by intrathecal administration of the orexin 1 receptor antagonist. These results indicate that linalool odor exposure drives the orexinergic descending pathway and suppresses nociceptive information flow at the spinal level.\n\nYurina Higa, Hideki Kashiwadani, Mitsutaka Sugimura, Tomoyuki Kuwaki\nOrexinergic descending inhibitory pathway mediates linalool odor-induced analgesia in mice\nScientific Reports 11, 9224, 2021\nhttps://doi.org/10.1038/s41598-021-88359-5","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第629号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"nature","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:杉村光隆】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2021-11-04"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"比嘉, 憂理奈","creatorNameLang":"ja"},{"creatorName":"ヒガ, ユリナ","creatorNameLang":"ja-Kana"},{"creatorName":"Higa, Yurina","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-06-17"}],"displaytype":"detail","filename":"Diss_比嘉_憂理奈_ISK629_2021.pdf","filesize":[{"value":"3.0 MB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"Diss_比嘉_憂理奈_ISK629_2021","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/16081/files/Diss_比嘉_憂理奈_ISK629_2021.pdf"},"version_id":"f9c721b7-ff30-460e-8587-a058681efeb3"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-06-14"}],"displaytype":"detail","filename":"Abstract_比嘉_憂理奈_4517810295_2021.pdf","filesize":[{"value":"128.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Abstract_比嘉_憂理奈_4517810295_2021","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/16081/files/Abstract_比嘉_憂理奈_4517810295_2021.pdf"},"version_id":"f3fa590f-528a-44c8-b85e-a26692a89e9c"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-23"}],"displaytype":"detail","filename":"Result_Higa_Yurina_isk_629.pdf","filesize":[{"value":"6.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Result_Higa_Yurina_isk_629","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/16081/files/Result_Higa_Yurina_isk_629.pdf"},"version_id":"86f5f2de-0bb3-4810-ba73-8128b446d935"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-23"}],"displaytype":"detail","filename":"Comments_Higa_Yurina_isk_629.pdf","filesize":[{"value":"2.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_Higa_Yurina_isk_629","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/16081/files/Comments_Higa_Yurina_isk_629.pdf"},"version_id":"bbe55685-364c-4df5-9337-a27a88d24e0e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Orexinergic descending inhibitory pathway mediates linalool odor-induced analgesia in mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Orexinergic descending inhibitory pathway mediates linalool odor-induced analgesia in mice","subitem_title_language":"en"},{"subitem_title":"マウスにおけるリナロール香気誘発性鎮痛にはオレキシン性下行性疼痛抑制系が関与している","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-05-23"},"publish_date":"2022-05-23","publish_status":"0","recid":"16081","relation_version_is_last":true,"title":["Orexinergic descending inhibitory pathway mediates linalool odor-induced analgesia in mice"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T02:05:53.854810+00:00"}