{"created":"2023-07-25T08:14:54.662227+00:00","id":16101,"links":{},"metadata":{"_buckets":{"deposit":"9f734326-6f7e-40e4-bf7c-a8d1e3f82200"},"_deposit":{"created_by":18,"id":"16101","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"16101"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00016101","sets":["57:86"]},"author_link":["140669"],"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2022-03-04","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2022-03-25"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(歯学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Dental Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Bone morphogenetic protein (BMP) 9 is one of the most osteogenic BMPs, but its mechanism of action has not been fully elucidated. Hes1, a transcriptional regulator with a basic helix-loop-helix domain, is a well-known effector of Notch signaling. Here, we find that BMP9 induces periodic increases of Hes1 mRNA and protein expression in osteoblasts, presumably through an autocrine negative feedback mechanism. BMP9-mediated Hes1 induction is significantly inhibited by an ALK inhibitor and overexpression of Smad7, an inhibitory Smad. Luciferase and ChIP assays revealed that two Smad-binding sites in the 5′ upstream region of the mouse Hes1 gene are essential for transcriptional activation by BMP9. Thus, our data indicate that BMP9 induces Hes1 expression in osteoblasts via the Smad signaling pathway.\n\nThis is the peer reviewed version of the following article: \nChang-Hwan Seong, Norika Chiba, Joji Kusuyama, Muhammad Subhan Amir, Nahoko Eiraku, Sachiko Yamashita, Tomokazu Ohnishi, Norifumi Nakamura, Tetsuya Matsuguchi\nBone morphogenetic protein 9 (BMP9) directly induces Notch effector molecule Hes1 through the SMAD signaling pathway in osteoblasts\nFEBS Letters 595(3), p.389–403, 2020,\nwhich has been published in final form at https://doi.org/10.1002/1873-3468.14016.\nThis article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第648号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Federation of European Biochemical Societies","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:中村典史】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2021-05-06"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"成, 昌奐","creatorNameLang":"ja"},{"creatorName":"Seong, Chang-Hwan","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-07-28"}],"displaytype":"detail","filename":"Diss_成_昌奐_ISK648_2021.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Diss_成_昌奐_ISK648_2021","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/16101/files/Diss_成_昌奐_ISK648_2021.pdf"},"version_id":"324fb345-984e-44a0-91bf-a5f82f07e174"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-07-28"}],"displaytype":"detail","filename":"Abstract_成_昌奐_4518810217_2021.pdf","filesize":[{"value":"206.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Abstract_成_昌奐_4518810217_2021","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/16101/files/Abstract_成_昌奐_4518810217_2021.pdf"},"version_id":"752bc721-e3cc-47e0-b06e-468401e95eaf"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-27"}],"displaytype":"detail","filename":"Result_Seong_Chang_Hwan_isk_648.pdf","filesize":[{"value":"4.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Result_Seong_Chang_Hwan_isk_648","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/16101/files/Result_Seong_Chang_Hwan_isk_648.pdf"},"version_id":"f6dc1bce-b95a-4fc9-8105-7f96c0e3e21d"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-27"}],"displaytype":"detail","filename":"Comments_Seong_Chang_Hwan_isk_648.pdf","filesize":[{"value":"2.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_Seong_Chang_Hwan_isk_648","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/16101/files/Comments_Seong_Chang_Hwan_isk_648.pdf"},"version_id":"ee0da2bc-5e72-466f-9cbc-632bda599398"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Bone  Morphogenetic  Protein  9","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"bone  regeneration","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Hes1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"notch","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"osteogenic differentiation","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Bone morphogenetic protein 9 (BMP9) directly induces Notch effector molecule Hes1 through the SMAD signaling pathway in osteoblasts","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Bone morphogenetic protein 9 (BMP9) directly induces Notch effector molecule Hes1 through the SMAD signaling pathway in osteoblasts","subitem_title_language":"en"},{"subitem_title":"BMP9は骨芽細胞においてSMADシグナル経路を介してNotchエフェクター分子であるHes1を誘導する","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-05-27"},"publish_date":"2022-05-27","publish_status":"0","recid":"16101","relation_version_is_last":true,"title":["Bone morphogenetic protein 9 (BMP9) directly induces Notch effector molecule Hes1 through the SMAD signaling pathway in osteoblasts"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T02:06:44.484376+00:00"}