{"created":"2023-07-25T08:14:54.887761+00:00","id":16106,"links":{},"metadata":{"_buckets":{"deposit":"3be8ba21-30ec-4ccd-a499-8572529c1dea"},"_deposit":{"created_by":18,"id":"16106","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"16106"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00016106","sets":["57:86"]},"author_link":["140683"],"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2022-03-04","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2022-03-11"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(歯学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Dental Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Mucoepidermoid carcinoma (MEC) is one of the most common malignant salivary gland carcinomas, but no effective treatment strategy has been established other than surgical resection. Purkinje cell protein (PCP) 4/peptide (PEP) 19 is a calmodulin-binding antiapoptotic peptide that is expressed and inhibits apoptosis in human breast cancer cells. Human epidermal growth factor receptor 2 (HER2) is an epidermal growth factor that has been implicated in the pathogenesis of many carcinomas, particularly breast and gastric carcinomas. In the present study, we performed immunohistochemical analyses of samples from 73 patients who underwent surgical resection for MEC of the salivary gland using antibodies against PCP4/PEP19 and HER2. PCP4/PEP19 expression was related to better prognosis, while HER2 expression was associated with worse prognosis. Patients that were PCP4/PEP19-positive and HER2-negative showed similar outcomes to PCP4/PEP19 and HER2 alone. Therefore, PCP4/PEP19 and HER2 are predicted to play important roles in the pathogenesis and progression of MEC.\n\nTakuya Yoshimura, Shotaro Higashi, Sohsuke Yamada, Hirotsugu Noguchi, Mitsuharu Nomoto, Hajime Suzuki, Takayuki Ishida, Hirotaka Takayama, Yuka Hirano, Masaru Yamashita, Akihide Tanimoto and Norifumi Nakamura\nPCP4/PEP19 and HER2 Are Novel Prognostic Markers in Mucoepidermoid Carcinoma of the Salivary Gland\nCancers 2022, 14(1), 54\nhttps://doi.org/10.3390/cancers14010054","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第653号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:中村典史】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2022-02-02"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"東, 翔太朗","creatorNameLang":"ja"},{"creatorName":"ヒガシ, ショウタロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Higashi, Shotaro","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-20"}],"displaytype":"detail","filename":"Diss_東_翔太朗_ISK653_2021.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"Diss_東_翔太朗_ISK653_2021","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/16106/files/Diss_東_翔太朗_ISK653_2021.pdf"},"version_id":"4789a0c9-7779-43d8-afb2-145c7e9ebcbf"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-08-01"}],"displaytype":"detail","filename":"Abstract_東_翔太朗_4518810333_2021.pdf","filesize":[{"value":"299.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Abstract_東_翔太朗_4518810333_2021","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/16106/files/Abstract_東_翔太朗_4518810333_2021.pdf"},"version_id":"4317df13-6761-4cf4-8454-09f0be2a1c55"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-06-06"}],"displaytype":"detail","filename":"Result_Higashi_Shotaro_isk_653.pdf","filesize":[{"value":"182.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Result_Higashi_Shotaro_isk_653","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/16106/files/Result_Higashi_Shotaro_isk_653.pdf"},"version_id":"0871510b-4ed3-46ce-9902-deaa2a5b7e24"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-27"}],"displaytype":"detail","filename":"Comments_Higashi_Shotaro_isk_653.pdf","filesize":[{"value":"2.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_HIgashi_Shotaro_isk_653","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/16106/files/Comments_Higashi_Shotaro_isk_653.pdf"},"version_id":"8df25abb-01d3-46a2-b721-a92c43b049fc"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"mucoepidermoid carcinoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Purkinje cell protein 4/peptide 19","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"human epidermal growth factor 2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"prognosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"salivary gland","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"PCP4/PEP19 and HER2 Are Novel Prognostic Markers in Mucoepidermoid Carcinoma of the Salivary Gland","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"PCP4/PEP19 and HER2 Are Novel Prognostic Markers in Mucoepidermoid Carcinoma of the Salivary Gland","subitem_title_language":"en"},{"subitem_title":"PCP4/PEPl9及びHER2は唾液腺粘表皮癌における新規の予後判定マーカーである","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-05-27"},"publish_date":"2022-05-27","publish_status":"0","recid":"16106","relation_version_is_last":true,"title":["PCP4/PEP19 and HER2 Are Novel Prognostic Markers in Mucoepidermoid Carcinoma of the Salivary Gland"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T02:06:57.521107+00:00"}