{"created":"2023-07-25T08:14:54.935170+00:00","id":16107,"links":{},"metadata":{"_buckets":{"deposit":"c12c81fe-1ba6-4795-b2ff-596e8ffd6cdd"},"_deposit":{"created_by":18,"id":"16107","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"16107"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00016107","sets":["57:86"]},"author_link":["140686"],"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2022-03-04","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2022-03-11"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Background: We previously reported that to-and-fro blood movement near the pulmonary vein stump was particularly prominent after left upper lobectomy compared with other lobectomy, which may be the cause of the high susceptibility of pulmonary vein thrombus after left upper lobectomy. The aim of the present study was to compare the hemodynamics in patients who developed pulmonary vein thrombus after left upper lobectomy with those in patients who did not develop pulmonary vein thrombus using four-dimensional flow magnetic resonance imaging (4D MRI).\nMethods: This was a retrospective evaluation of a prospectively collected clinical and radiological database of 37 patients who underwent 4D MRI 7 days after left upper lobectomy for lung cancer (n=37). We obtained two parameters by 4D MRI: the grade of to-and-fro blood movement and the flow energy loss around the pulmonary vein stump. The length of the pulmonary vein stump, a known risk factor for pulmonary vein thrombus, was also measured.\nResults: According to a scatterplot of the grade of to-and-fro blood movement versus the flow energy loss, patients with pulmonary vein thrombus (n=15) were concentrated in an area which appears to be a ‘dangerous’ hemodynamic condition. There were few patients without pulmonary vein thrombus in this ‘dangerous’ area, except for one who unfortunately developed delayed pulmonary vein thrombus and cerebral infarction. We proposed a formula using the 4D MRI-derived parameters based on a stepwise multiple regression analysis that was more closely associated with the development of pulmonary vein thrombus than the length of the pulmonary vein stump (area under the receiver operating characteristics curve: 0.918 vs. 0.705, P=0.0500).\nConclusions: We proposed the existence of a ‘dangerous’ hemodynamic condition responsible for pulmonary vein thrombus formation. 4D MRI before the development of pulmonary vein thrombus may help identify patients requiring preventive therapy against pulmonary vein thrombus and subsequent thromboembolic complications.\n\nTadashi Umehara, Koji Takumi, Kazuhiro Ueda, Takuya Tokunaga, Aya Harada-Takeda, Masami Sato\nHemodynamic features underlying pulmonary vein stump thrombus formation after left upper lobectomy: four-dimensional flow magnetic resonance imaging study\nQuantitative Imaging in Medicine and Surgery 2022;12(2):992-1003\nhttps://dx.doi.org/10.21037/qims-21-472","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第654号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"AME Publishing Company","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:佐藤雅美】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2021-11-04"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"梅原, 正","creatorNameLang":"ja"},{"creatorName":"ウメハラ, タダシ","creatorNameLang":"ja-Kana"},{"creatorName":"Umehara, Tadashi","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-10"}],"displaytype":"detail","filename":"Diss_梅原_正_ISK654_2021.pdf","filesize":[{"value":"864.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"Diss_梅原_正_ISK654_2021","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/16107/files/Diss_梅原_正_ISK654_2021.pdf"},"version_id":"3097efd5-7df2-449c-9cd4-8666ca782724"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-08-01"}],"displaytype":"detail","filename":"Abstract_梅原_正_4519810070_2021.pdf","filesize":[{"value":"76.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Abstract_梅原_正_4519810070_2021","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/16107/files/Abstract_梅原_正_4519810070_2021.pdf"},"version_id":"ac1b4467-1562-42ac-ad06-6cb8a9c6a042"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-27"}],"displaytype":"detail","filename":"Result_Umehara_Tadashi_isk_654.pdf","filesize":[{"value":"5.9 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Result_Umehara_Tadashi_isk_654","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/16107/files/Result_Umehara_Tadashi_isk_654.pdf"},"version_id":"0e1d2cd4-7ccd-4f82-b77f-aa513cda0abc"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-27"}],"displaytype":"detail","filename":"Comments_Umehara_Tadashi_isk_654.pdf","filesize":[{"value":"2.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_Umehara_Tadashi_isk_654","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/16107/files/Comments_Umehara_Tadashi_isk_654.pdf"},"version_id":"dddbca4a-b423-4a48-aed7-dbed5feec9c2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Pulmonary vein stump thrombus","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"four-dimensional flow magnetic resonance imaging (4D MRI)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"left upper lobectomy (LUL)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"lung cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Hemodynamic features underlying pulmonary vein stump thrombus formation after left upper lobectomy: Four-dimensional flow magnetic resonance imaging study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Hemodynamic features underlying pulmonary vein stump thrombus formation after left upper lobectomy: Four-dimensional flow magnetic resonance imaging study","subitem_title_language":"en"},{"subitem_title":"左肺上葉切除後の肺静脈断端血栓の原因となる血行動態の特徴 : 4D flow MRIを用いた研究","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-05-27"},"publish_date":"2022-05-27","publish_status":"0","recid":"16107","relation_version_is_last":true,"title":["Hemodynamic features underlying pulmonary vein stump thrombus formation after left upper lobectomy: Four-dimensional flow magnetic resonance imaging study"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T02:07:04.616458+00:00"}