{"created":"2023-07-25T08:14:55.168287+00:00","id":16111,"links":{},"metadata":{"_buckets":{"deposit":"5faf01d6-834f-4cb5-854e-1047edb43716"},"_deposit":{"created_by":18,"id":"16111","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"16111"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00016111","sets":["57:86"]},"author_link":["140696"],"control_number":"16111","item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2022-04-12","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2022-04-20"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(歯学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Dental Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Ameloblastoma is an odontogenic tumor located in the bone jaw with clinical characteristics of extensive bone resorption. It is a locally invasive tumor with a high recurrence rate despite adequate surgical removal. In bone disease, tumors and other cells including osteoblasts, osteoclasts, and osteocytes in the bone microenvironment contribute to the pathogenesis of tumor growth. However, the effect of osteoblasts on ameloblastoma cells is not well-understood, and there has been limited research on interactions between them.\nThis study investigated interactions between ameloblastoma cells and osteoblasts using a human ameloblastoma cell line (AM-3 ameloblastoma cells) and a murine pre-osteoblast cell line (MC3T3-E1 cells). We treated each cell type with the conditioned medium by the other cell type. We analyzed the effect on cytokine production by MC3T3-E1 cells and the production of MMPs by AM-3 cells. Treatment with AM-3-conditioned medium induced inflammatory cytokine production of IL-6, MCP-1, and RANTES from MC3T3-E1 cells. The use of an IL-1 receptor antagonist suppressed the production of these inflammatory cytokines by MC3T3-E1 cells stimulated with AM-3-conditioned medium. The MC3T3-E1-conditioned medium triggered the expression of MMP-2 from AM-3 cells. Furthermore, we have shown that the proliferation and migration activity of AM-3 cells were accelerated by MC3T3-E1 conditioned media.\nIn conclusion, these intercellular signalings between ameloblastoma cells and osteoblasts may play multiple roles in the pathogenesis of ameloblastoma.\n\nElissa Chairani, Takao Fuchigami, Hirofumi Koyama, Yusuke Ono, Mikio Iijima, Michiko Kishida, Toshiro Kibe, Norifumi Nakamura, Shosei Kishida\nIntercellular signaling between ameloblastoma and osteoblasts\nBiochemistry and Biophysics Reports 30 (2022) 101233\nhttps://doi.org/10.1016/j.bbrep.2022.101233","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第657号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:中村典史】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2022-03-02"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Chairani, Elissa","creatorNameLang":"en"},{"creatorName":"ハイラニ, エリサ","creatorNameLang":"ja"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-06-22"}],"displaytype":"detail","filename":"Diss_エリサ_ハイラニ_ISK657_2022.pdf","filesize":[{"value":"1.8 MB"}],"format":"application/pdf","licensefree":"Copyright© 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Diss_エリサ_ハイラニ_ISK657_2022","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/16111/files/Diss_エリサ_ハイラニ_ISK657_2022.pdf"},"version_id":"a2697024-1d1f-4103-bdd3-315401217b48"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-06-23"}],"displaytype":"detail","filename":"Abstract_エリサ_ハイラニ_4518810404_2022.pdf","filesize":[{"value":"128.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Abstract_エリサ_ハイラニ_4518810404_2022","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/16111/files/Abstract_エリサ_ハイラニ_4518810404_2022.pdf"},"version_id":"a9278fd7-ddad-44a7-bac9-72b1586b9bb2"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-30"}],"displaytype":"detail","filename":"Result_Elissa_Chairani_isk_657.pdf","filesize":[{"value":"158.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Result_Elissa_Chairani_isk_657","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/16111/files/Result_Elissa_Chairani_isk_657.pdf"},"version_id":"5e4e37f2-6e54-4cf8-a85e-7dae44651018"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-30"}],"displaytype":"detail","filename":"Comments_Elissa_Chairani_isk_657.pdf","filesize":[{"value":"113.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_Elissa_Chairani_isk_657","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/16111/files/Comments_Elissa_Chairani_isk_657.pdf"},"version_id":"70feaf49-f277-40d4-9d17-01962714d960"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Ameloblastoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"AM-3","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Osteoblast","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Tumor-bone microenvironment","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cytokine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Intercellular communication","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Intercellular Siganling between Ameloblastoma and Osteoblasts","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Intercellular Siganling between Ameloblastoma and Osteoblasts","subitem_title_language":"en"},{"subitem_title":"エナメル上皮腫細胞と骨芽細胞の細胞間シグナル伝達について","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-05-30"},"publish_date":"2022-05-30","publish_status":"0","recid":"16111","relation_version_is_last":true,"title":["Intercellular Siganling between Ameloblastoma and Osteoblasts"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-11T00:52:30.932161+00:00"}